Paper Details

  1. Home
  2. Paper Details

Chemotherapy in advanced non-small cell lung cancer.

Author: SplinterT A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This review of 142 studies on chemotherapy for advanced non-small cell lung cancer (NSCLC) found that while chemotherapy can improve survival and response rates, there are significant differences in outcomes depending on factors like patient health, tumor size, and treatment center. The study suggests that new drugs should be compared to standard treatments, and that further research is needed to assess the effectiveness of chemotherapy in specific groups of patients with advanced NSCLC. The review also emphasizes the importance of studying the palliative effects of chemotherapy, particularly in alleviating symptoms and improving quality of life for patients with advanced lung cancer.
Paper Details　
Original Abstract of the Article :
Chemotherapy in advanced non-small cell lung cancer (NSCLC) has been evaluated with response rate, survival and quality of life as criteria. The data were collected from 142 phase II and III trials. The three main conclusions are: (1) multivariate landmark analyses show that a response to chemothera...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0277-5379(90)90059-3

データ提供：米国国立医学図書館（NLM）

Chemotherapy in Advanced Non-Small Cell Lung Cancer

Lung cancer is a leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC), a type of lung cancer that accounts for the majority of lung cancers, presents a significant challenge for healthcare professionals. This study delves into the role of chemotherapy in treating advanced NSCLC, analyzing data from numerous phase II and III trials. The authors meticulously evaluate the effectiveness of chemotherapy in terms of response rate, survival, and quality of life, seeking to understand its impact on patient outcomes.

Chemotherapy's Role in Advanced NSCLC

This study provides a comprehensive analysis of chemotherapy in advanced NSCLC, highlighting its impact on response rate, survival, and quality of life. The authors emphasize the importance of a personalized approach to chemotherapy, considering individual patient characteristics and the heterogeneous nature of NSCLC. The study identifies factors that influence response and survival, including treatment center and performance status. The researchers also highlight the importance of response rate as a prognostic factor, suggesting that a response to chemotherapy is associated with improved survival.

Guiding Future Research and Clinical Practice

This study provides valuable insights into the role of chemotherapy in advanced NSCLC, offering guidance for future research and clinical practice. The authors emphasize the need for randomized controlled trials to evaluate new drugs against standard treatments and identify optimal treatment strategies for specific patient subgroups. The study also calls for further investigation into the palliative effects of chemotherapy, focusing on improving quality of life for patients with symptoms. You know, just like a camel adapts to the harsh desert environment, healthcare professionals are continuously seeking innovative treatments for lung cancer.

Dr. Camel's Conclusion

This study provides a comprehensive analysis of chemotherapy in advanced non-small cell lung cancer (NSCLC), highlighting its impact on response rate, survival, and quality of life. The authors emphasize the importance of a personalized approach to chemotherapy, considering individual patient characteristics and the heterogeneous nature of NSCLC. The study identifies factors that influence response and survival, including treatment center and performance status. This research offers valuable insights into the role of chemotherapy in advanced NSCLC, guiding future research and clinical practice.

Date :
  1. Date Completed 1991-03-06
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

2177347

DOI: Digital Object Identifier

10.1016/0277-5379(90)90059-3

Related Literature

Article Analysis
・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.