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Silymarin ameliorates cisplatin-induced hepatotoxicity in rats: histopathological and ultrastructural studies.

Author: AbdelmeguidN E, Abou ZeinabN S, ChmaisseH N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Silymarin, a plant extract with antioxidant properties, was found to protect against cisplatin-induced liver toxicity in rats.
Paper Details　
Original Abstract of the Article :
The benefit of silymarin, a plant extract with strong antioxidant activity against hepatotoxicity induced by cisplatin in rats was investigated in this study. Cisplatin is one of the most effective chemotherapeutic drugs, yet it alone does not achieve a satisfactory therapeutic outcome and at high d...See full text at original site
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引用元：
https://doi.org/10.3923/pjbs.2010.463.479

データ提供：米国国立医学図書館（NLM）

The Protective Effects of Silymarin Against Cisplatin-Induced Hepatotoxicity

This study investigates the potential of silymarin, a plant extract with antioxidant properties, to ameliorate cisplatin-induced hepatotoxicity in rats. The authors used histopathological and ultrastructural studies to assess the protective effects of silymarin against cisplatin-induced liver damage.

Silymarin Shows Promise as a Hepatoprotective Agent

The study found that silymarin, especially when administered before cisplatin, significantly reduced the pathological changes induced by cisplatin. This suggests that silymarin may have a protective effect against cisplatin hepatotoxicity. The study found that silymarin, especially when administered before cisplatin, significantly reduced the pathological changes induced by cisplatin, suggesting its potential as a protective agent against cisplatin hepatotoxicity.

A Potential Natural Solution for Reducing Cisplatin Toxicity

This study highlights the potential of silymarin as a natural supplement for reducing cisplatin toxicity. Further research is needed to confirm its efficacy and safety in humans.

Dr.Camel's Conclusion

This study, like a thirsty traveler finding a cool spring in the desert, reveals the potential of silymarin to combat the damaging effects of cisplatin. Silymarin, like a hardy desert plant, may offer a natural defense against the harsh effects of this chemotherapy drug. While further research is needed, this study offers a glimmer of hope for reducing the side effects associated with cisplatin treatment.
Date :
  1. Date Completed 2011-09-06
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

21848071

DOI: Digital Object Identifier

10.3923/pjbs.2010.463.479

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Article Analysis
・Side Effects of cisplatin injection
SNS
PICO Info
in preparation
Languages

English

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