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Thiazide and loop diuretics.

Author: CarterBarry, CushmanWilliam, HammLee, SicaDomenic A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review focuses on the use of thiazide-type diuretics (chlorthalidone, hydrochlorothiazide) and loop diuretics (furosemide) for hypertension. Chlorthalidone, with a longer half-life and larger volume of distribution, offers a sustained blood pressure reduction compared to hydrochlorothiazide. Loop diuretics are not recommended as first-line therapy due to the lack of outcome data and should be reserved for conditions like fluid overload or advanced renal failure. The review highlights the efficacy, safety, and potential adverse effects of these diuretics, emphasizing their role in hypertension management.
Paper Details　
Original Abstract of the Article :
KEY POINTS AND PRACTICAL RECOMMENDATIONS: •  Although chlorthalidone and hydrochlorothiazide are structurally similar, they are very different pharmacokinetically, with chlorthalidone having both an extremely long half-life (approximately 40 to 60 hours) and a large volume of distribution, with grad...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108854/

データ提供：米国国立医学図書館（NLM）

Thiazide and Loop Diuretics: A Comprehensive Review

This comprehensive review provides an insightful overview of [thiazide and loop diuretics] for [hypertension] management. The authors meticulously analyze the pharmacokinetic properties, clinical efficacy, and potential side effects of these diuretics. They explore the differences between [chlorthalidone] and [hydrochlorothiazide] and discuss the intricacies of [furosemide] absorption. The study also highlights the importance of considering [individual patient factors] when selecting diuretic therapy. This review provides a valuable resource for clinicians seeking to optimize [hypertension] treatment.

Diuretics in Hypertension: Navigating the Desert of High Blood Pressure

This review serves as a valuable guide for navigating the complexities of [hypertension] management. It provides a comprehensive overview of the different classes of [diuretics], their mechanisms of action, and their potential benefits and risks. The authors highlight the importance of individualized treatment approaches, taking into account patient-specific factors such as [renal function], [electrolyte balance], and [comorbidities]. The review also emphasizes the need for careful monitoring and ongoing evaluation of [diuretic therapy] to ensure optimal outcomes.

Diuretics: A Cornerstone of Hypertension Management

This comprehensive review underscores the vital role of [diuretics] in the management of [hypertension]. It provides a detailed analysis of the various types of diuretics, their mechanisms of action, and their clinical efficacy. The review highlights the importance of considering factors such as [individual patient characteristics], [drug interactions], and [potential side effects] when selecting a diuretic regimen. This review offers a valuable resource for healthcare professionals seeking to optimize [hypertension] treatment and improve patient outcomes.

Dr.Camel's Conclusion

Navigating the complexities of [hypertension] management can feel like traversing a vast desert, but this review provides a helpful roadmap. It outlines the key considerations for choosing and managing [diuretics], emphasizing the importance of individualized treatment and ongoing monitoring. This comprehensive resource equips healthcare professionals with the knowledge they need to make informed decisions regarding [hypertension] treatment.

Date :
  1. Date Completed 2012-01-26
  2. Date Revised 2021-12-17
Further Info :

Pubmed ID

21896142

DOI: Digital Object Identifier

PMC8108854

SNS
PICO Info
in preparation
Languages

English

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