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Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus.

Author: BrownKyle S, EbiharaHideki, FeldmannHeinz, MarziAndrea, SafronetzDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Andes virus (ANDV) is a highly pathogenic hantavirus causing hantavirus pulmonary syndrome (HPS) in South America. A vaccine is urgently needed due to the high fatality rate and lack of effective therapies. This study developed a recombinant vesicular stomatitis virus (VSV) vector expressing the ANDV surface glycoprotein precursor. Hamsters immunized with this vaccine were fully protected against lethal ANDV challenge. The protection was likely due to the induction of neutralizing antibodies and a potent antiviral state. The VSV platform shows potential as a fast-acting and effective prophylaxis and post-exposure treatment for hantavirus infections.
Paper Details　
Original Abstract of the Article :
Andes virus (ANDV) is a highly pathogenic South American hantavirus that causes hantavirus pulmonary syndrome (HPS). A high case fatality rate, the potential for human-to-human transmission, the capacity to infect via aerosolization, and the absence of effective therapies make it imperative that a s...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209372/

データ提供：米国国立医学図書館（NLM）

A Promising Vaccine for Andes Virus Infection

The world of [virology] is a fascinating desert, where viruses like [Andes virus (ANDV)] can cause devastating illnesses like [hantavirus pulmonary syndrome (HPS)]. This study, like a group of explorers searching for a cure in the heart of this desert, investigated a novel [vaccine] based on a [vesicular stomatitis virus (VSV)] vector expressing the [ANDV surface glycoprotein precursor (VSVΔG/ANDVGPC)]. They tested the efficacy of this vaccine in [Syrian hamsters], the only lethal-disease animal model for [HPS].

A VSV-Based Vaccine: A Potential Solution

The findings, like a hidden oasis discovered in the desert, suggest that the [VSVΔG/ANDVGPC] vaccine is highly effective in protecting hamsters against [lethal challenge] with [ANDV]. The vaccinated hamsters demonstrated complete protection against disease when challenged at various time points before and after immunization, suggesting that the vaccine can provide both prophylactic and therapeutic benefits. This discovery is a major step forward in the fight against [ANDV] infection and could lead to the development of a safe and effective vaccine for humans.

The Potential Impact of this Vaccine

This study, like a beacon of hope shining in the desert, offers a promising solution for protecting individuals from the deadly effects of [ANDV] infection. The development of a [VSV-based vaccine] has the potential to significantly impact the lives of those living in regions where [ANDV] is endemic, offering protection from this devastating disease. This research is a testament to the ongoing efforts of scientists to combat emerging infectious diseases and improve global health.

Dr.Camel's Conclusion

The desert of [infectious diseases] is filled with dangerous pathogens, but this study offers a glimmer of hope in the form of a promising vaccine. Just as a camel can traverse the harshest deserts, this [VSV-based vaccine] has the potential to protect individuals from the threat of [ANDV] infection. This discovery is a testament to the power of scientific innovation and the relentless pursuit of solutions for global health challenges.

Date :
  1. Date Completed 2012-01-19
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

21917979

DOI: Digital Object Identifier

PMC3209372

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・Effective treatment of hantavirus infections
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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