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Surface thermodynamics of mucoadhesive dry powder formulation of zolmitriptan.

Author: AlhalawehAmjad, GaviniElisabetta, RassuGiovanna, VelagaSitaram P, VilinskaAnnamaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of different polymers on the surface chemistry and adhesion potential of spray-dried microparticles for nasal delivery of zolmitriptan. The study used chitosans of varying molecular weights and hydroxypropyl methyl cellulose. The results suggest that higher molecular weight chitosans and formulations with a higher polymer content show improved adhesion to mucin and nasal tissue. These findings provide valuable insights for optimizing nasal drug delivery formulations.
Paper Details　
Original Abstract of the Article :
Microparticle powders for nasal delivery were formulated to contain the model drug, zolmitriptan, and varying proportions of different polymers. The objective of the study was to investigate the effects of these formulative parameters on the surface chemistry of the spray-dried microparticles and th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225526/

データ提供：米国国立医学図書館（NLM）

Adhesion and Surface Properties: A Key to Effective Nasal Drug Delivery

Delivering drugs via the nasal route presents unique challenges, including the need for effective adhesion to the nasal mucosa. This study investigated the surface properties of spray-dried microparticles formulated to contain zolmitriptan, a drug used to treat migraines. The researchers used various polymers, including chitosans and hydroxypropyl methylcellulose, to create microparticles with different surface energies. They then measured the contact angles of these microparticles on porcine mucin and nasal tissue to determine their potential for adhesion. The researchers found that the formulations with higher molecular weight chitosans and higher polymer content exhibited greater theoretical adhesion to both mucin and nasal tissue.

A Precise Approach to Nasal Drug Delivery: Surface Chemistry Matters

This study highlights the importance of carefully controlling the surface properties of nasal drug delivery formulations. By manipulating the composition and structure of the microparticles, researchers can optimize their adhesion to the nasal mucosa, potentially leading to improved drug absorption and therapeutic efficacy.

Navigating the Nasal Passage: A Sticky Situation

The nasal passage is a complex and delicate environment. To ensure effective drug delivery, it's crucial for formulations to adhere to the nasal mucosa without causing irritation or damage. This study provides valuable insights into the design and development of nasal drug delivery systems, offering a roadmap for creating formulations that can effectively deliver their payload while minimizing potential side effects.

Dr.Camel's Conclusion

This research is like a camel navigating a sand dune – understanding the surface properties of microparticles is essential for ensuring a smooth and successful journey through the nasal passage. This study provides a blueprint for designing nasal drug delivery systems that can effectively adhere to the nasal mucosa, leading to improved drug absorption and therapeutic outcomes.

Date :
  1. Date Completed 2012-03-26
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21918918

DOI: Digital Object Identifier

PMC3225526

Related Literature

Article Analysis
・Effects of zolmitriptan
SNS
PICO Info
in preparation
Languages

English

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