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Clinical trials in locally advanced breast cancer.

Author: WallgrenA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Survival after treatment of locally advanced breast cancer remains poor. While retrospective studies suggest that systemic treatment might be beneficial, a review of clinical trials failed to show consistent survival benefits. Increasing radiotherapy doses or adding endocrine or cytostatic treatment may improve local control. Further research is needed to identify more effective treatments.
Paper Details　
Original Abstract of the Article :
Survival after treatment of locally advanced breast cancer is poor and resembles that for untreated breast cancer. Although retrospective comparisons have suggested that the addition of systemic treatment might be beneficial, a literature survey of the controlled clinical trials failed to show consi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/02841869009090014

データ提供：米国国立医学図書館（NLM）

Locally Advanced Breast Cancer: Navigating the Desert of Treatment

[Locally advanced breast cancer] presents a formidable challenge for clinicians, with limited treatment options and a challenging prognosis. This review article delves into the desert of [clinical trials] for locally advanced breast cancer, seeking to uncover effective treatment strategies. The authors analyze existing research, highlighting the lack of consistent survival benefits from various treatment modalities. However, they do identify promising results regarding local control, suggesting that increasing the dose of radiotherapy or combining it with endocrine or cytostatic treatment may improve outcomes. This research calls for further investigation into tailored treatment approaches that can effectively address the unique challenges of locally advanced breast cancer.

Locally Advanced Breast Cancer: Navigating the Desert of Treatment

This review highlights the need for further research into more effective treatments for locally advanced breast cancer. While current therapies may not significantly improve survival, the authors identify promising areas for investigation, particularly focusing on enhancing local control through radiation therapy and combination therapies. This research emphasizes the ongoing search for better treatment strategies to address the unique challenges of this challenging condition.

Locally Advanced Breast Cancer: Navigating the Desert of Treatment

This review underscores the need for continued research into more effective treatments for locally advanced breast cancer. The authors highlight the importance of focusing on improving local control and exploring new approaches that may lead to better outcomes. While the journey through the desert of treatment remains challenging, ongoing research offers hope for improved strategies and better support for patients battling this formidable disease.

Dr. Camel's Conclusion

The desert of locally advanced breast cancer treatment is vast and complex, but researchers continue to explore new pathways for better outcomes. This review highlights the need for continued research and the importance of personalized treatment approaches to address the unique challenges of this disease.

Date :
  1. Date Completed 1990-08-15
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

2194537

DOI: Digital Object Identifier

10.3109/02841869009090014

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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