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Human growth hormone prevents the protein catabolic side effects of prednisone in humans.
Author: HaymondM W, HorberF F
Original Abstract of the Article :
Prednisone treatment causes protein wasting and adds additional risks to a patient, whereas human growth hormone (hGH) treatment causes positive nitrogen balance. To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC296716/
データ提供:米国国立医学図書館(NLM)
Human Growth Hormone: A Oasis in the Desert of Prednisone Side Effects
The use of prednisone, a glucocorticosteroid, is a common treatment for a variety of inflammatory conditions. However, prednisone can have significant side effects, including protein wasting. This study, like a desert explorer seeking a solution to a pressing problem, investigates the potential of human growth hormone (hGH) to mitigate these negative effects. The authors conducted a study on healthy volunteers, comparing the effects of prednisone alone, hGH alone, and a combination of the two on protein metabolism.
Finding the Oasis: hGH and Prednisone Side Effects
The study revealed that hGH effectively prevented the protein catabolic side effects of prednisone. This is like discovering a hidden oasis in the desert, offering a respite from the harsh realities of prednisone treatment. The authors found that hGH alone increased protein synthesis and resulted in positive nitrogen balance, while prednisone alone induced protein wasting.
Navigating the Desert: Balancing Benefits and Risks
The study highlights the potential for hGH to mitigate the negative effects of prednisone treatment. However, it also acknowledges that hGH therapy itself carries potential risks and should be carefully considered and monitored. This is like finding a path through the desert, requiring us to weigh the potential benefits against the potential dangers.
Dr. Camel's Conclusion
This study offers a potential solution to the problem of protein wasting associated with prednisone treatment. While hGH therapy can provide a valuable oasis in the desert of prednisone side effects, careful consideration of its potential risks and benefits is crucial. As we continue to explore the landscape of prednisone treatment, we must seek innovative approaches that minimize negative effects and promote the well-being of patients.
Date :
- Date Completed 1990-08-13
- Date Revised 2018-11-13
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English
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