Human growth hormone prevents the protein catabolic side effects of prednisone in humans.

Author: HaymondM W, HorberF F

Paper Details 
Original Abstract of the Article :
Prednisone treatment causes protein wasting and adds additional risks to a patient, whereas human growth hormone (hGH) treatment causes positive nitrogen balance. To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC296716/

データ提供:米国国立医学図書館(NLM)

Human Growth Hormone: A Oasis in the Desert of Prednisone Side Effects

The use of prednisone, a glucocorticosteroid, is a common treatment for a variety of inflammatory conditions. However, prednisone can have significant side effects, including protein wasting. This study, like a desert explorer seeking a solution to a pressing problem, investigates the potential of human growth hormone (hGH) to mitigate these negative effects. The authors conducted a study on healthy volunteers, comparing the effects of prednisone alone, hGH alone, and a combination of the two on protein metabolism.

Finding the Oasis: hGH and Prednisone Side Effects

The study revealed that hGH effectively prevented the protein catabolic side effects of prednisone. This is like discovering a hidden oasis in the desert, offering a respite from the harsh realities of prednisone treatment. The authors found that hGH alone increased protein synthesis and resulted in positive nitrogen balance, while prednisone alone induced protein wasting.

Navigating the Desert: Balancing Benefits and Risks

The study highlights the potential for hGH to mitigate the negative effects of prednisone treatment. However, it also acknowledges that hGH therapy itself carries potential risks and should be carefully considered and monitored. This is like finding a path through the desert, requiring us to weigh the potential benefits against the potential dangers.

Dr. Camel's Conclusion

This study offers a potential solution to the problem of protein wasting associated with prednisone treatment. While hGH therapy can provide a valuable oasis in the desert of prednisone side effects, careful consideration of its potential risks and benefits is crucial. As we continue to explore the landscape of prednisone treatment, we must seek innovative approaches that minimize negative effects and promote the well-being of patients.

Date :
  1. Date Completed 1990-08-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

2195062

DOI: Digital Object Identifier

PMC296716

Related Literature

SNS
PICO Info
in preparation
Languages

English

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