Side Effects of prednisone: A Synthesis of Findings from 13 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of prednisone: A Synthesis of Findings from 13 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Studies on the side effects of prednisone have reported various side effects. For example, 6 showed that low-dose prednisone therapy was effective for patients with early active rheumatoid arthritis, but side effects were also reported. In addition, 8 suggested that human growth hormone could prevent the protein catabolic effects of prednisone. Furthermore, 3 compared the side effects of prednisone and methotrexate in patients with sarcoidosis and found that prednisone had more side effects.

Reasons for Side Effects

Prednisone's side effects are caused by its pharmacological effects. Prednisone is a type of steroid hormone called a glucocorticoid, which affects various physiological functions in the body. Prednisone's effects include anti-inflammatory, immunosuppressive, and metabolic-promoting effects. However, these effects can sometimes cause side effects.

Common Side Effects

Weight Gain

Prednisone's metabolic-promoting effect can increase appetite and lead to fat accumulation. Therefore, weight gain can occur. 6 ,

Swelling

Prednisone's effects can promote fluid retention in the body. Therefore, swelling can occur. 9 , 11

High Blood Pressure

Prednisone's effects can lead to an increase in blood pressure. 9

Increased Blood Sugar Levels

Prednisone's effects can increase blood sugar levels. 9

Osteoporosis

Prednisone's effects can inhibit bone formation, increasing the risk of osteoporosis.

Stomach Ulcers

Prednisone's effects can damage the stomach lining, increasing the risk of stomach ulcers.

Mental Effects

Prednisone's effects can lead to mood swings, anxiety, insomnia, and depression. 11 , 1

Increased Risk of Infection

Prednisone's immunosuppressive effect can make you more susceptible to infections.

Countermeasures for Side Effects

Weight Gain Countermeasures

Weight gain can be prevented through dietary therapy and exercise therapy.

Swelling Countermeasures

Swelling can be resolved through salt restriction and diuretic medication. 9

High Blood Pressure Countermeasures

Blood pressure can be controlled through antihypertensive medication. 9

Increased Blood Sugar Levels Countermeasures

Blood sugar levels can be controlled through dietary therapy, exercise therapy, and antidiabetic medication. 9

Osteoporosis Countermeasures

Osteoporosis can be prevented by consuming calcium and vitamin D, engaging in exercise therapy, and taking osteoporosis medications.

Stomach Ulcers Countermeasures

Stomach ulcers can be prevented by taking antacids.

Mental Effects Countermeasures

Mental effects can be reduced through psychotherapy, antianxiety medication, and antidepressants. 11 , 1

Increased Risk of Infection Countermeasures

The risk of infection can be reduced by practicing good hygiene, such as handwashing and gargling, and receiving vaccinations when necessary.

Comparison Between Studies

Common Points of Studies

Many studies agree that the side effects of prednisone are caused by its pharmacological effects. It is also commonly agreed that the side effects of prednisone vary depending on the dosage and duration of administration.

Differences Between Studies

Studies on the side effects of prednisone may have differences in results due to different target diseases and side effect evaluation methods.

Precautions for Application in Real Life

Prednisone's side effects vary from person to person. Even the same person may experience more side effects depending on their physical condition and the medications they are taking. If you are taking prednisone, follow your doctor's instructions carefully and consult your doctor immediately if you experience any side effects.

Limitations of Current Research

There is still insufficient research on the side effects of prednisone. In particular, there is still much that is unknown about long-term side effects.

Future Research Directions

Further research is needed to better understand the side effects of prednisone, such as long-term follow-up studies and investigations into the mechanisms of side effect development. The development of new treatments to reduce the side effects of prednisone is also expected.

Conclusion

Prednisone is an effective drug for treating many diseases, but it also has a number of side effects. It is important to understand the risks of side effects and consult your doctor carefully before taking prednisone. If you experience any side effects, consult your doctor immediately.

Literature analysis of 13 papers
Positive Content
11
Neutral Content
0
Negative Content
2
Article Type
1
0
2
2
13
1.

Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review.

Author: WarrisL T, van den Heuvel-EibrinkM M, den HoedM A H, AarsenF K, PietersR, van den AkkerE L T

ALL treatment
Neuropsychological side effects

Dexamethasone and prednisone are commonly used steroids for treating childhood acute lymphoblastic leukemia. This review found no clinically significant differences between the two drugs on cognitive, mood, or behavioral outcomes. This suggests that both drugs may be safe in terms of neuropsychological side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

A Canadian vasculitis patient-driven survey to highlight which prednisone-related side effects matter the most.

Author: YardimciGozde Kubra, PagnouxChristian, StewartJon

Treats vasculitis
Glucocorticoid side effects

Glucocorticoids (GC) are essential for treating vasculitis, but their side effects are not as well-studied in this patient population compared to other rheumatic conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review.

Author: WarrisL T, van den Heuvel-EibrinkM M, den HoedM A H, AarsenF K, PietersR, van den AkkerE L T

ALL treatment
Neuropsychological side effects

Dexamethasone and prednisone are commonly used steroids for treating childhood acute lymphoblastic leukemia. This review found no clinically significant differences between the two drugs on cognitive, mood, or behavioral outcomes. This suggests that both drugs may be safe in terms of neuropsychological side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial.

Author: van EverdingenAmalia A, JacobsJohannes W G, Siewertsz Van ReesemaDirk R, BijlsmaJohannes W J

Clinical improvement
Inhibited joint damage
Osteoporotic fractures

Low-dose prednisone (10mg/day) provided clinical benefit, especially in the first six months, for patients with early active rheumatoid arthritis who had not been treated with disease-modifying antirheumatic drugs. Radiologic joint damage progressed significantly less in the prednisone group compared to placebo. However, prednisone was associated with a higher incidence of osteoporotic fractures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Active constituents reducing side-effects of prednisone acetate in leaves of Panax ginseng C.A.Mey].

Author: DouD, WenY, PeiY, ChenY, MaZ

Ginsenosides
Lipid metabolism regulation

Total ginsenosides in the leaves of Panax ginseng can significantly inhibit the rise of total lipid, triglyceride, and total cholesterol, and the drop of cortisol in serum induced by PA. Ginsenoside-Re is the chief active constituent of GSL.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

8.

Human growth hormone prevents the protein catabolic side effects of prednisone in humans.

Author: HorberF F, HaymondM W

Prevents protein wasting

Concomitant administration of human growth hormone (hGH) was found to prevent the protein catabolic effects of prednisone in healthy volunteers. Prednisone alone induced protein wasting (P less than 0.001), while hGH alone resulted in positive protein balance (P less than 0.001). Combined treatment prevented the glucocorticoid-induced protein catabolism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases.

Author: LozadaF, SilvermanS, MiglioratiC

Oral inflammation
Prednisone treatment
Fluid retention
Insomnia

Prednisone was effective in reducing signs and symptoms in 101 patients with acute and chronic oral inflammatory diseases. Adverse side effects, which occurred in 61 patients, were primarily related to treatment that persisted for more than two weeks.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

Prednisone for chronic active hepatitis: pharmacokinetics and serum binding in patients with chronic active hepatitis and steroid major side effects.

Author: UribeM, GoV L, KlugeD

Side effects

Patients with chronic active hepatitis who developed major side effects from prednisone had higher serum bilirubin and lower serum albumin levels than those with fewer side effects. This may be due to increased serum unbound prednisolone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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