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Comparison of simvastatin and cholestyramine in the treatment of primary hypercholesterolaemia.

Author: CliftonP, CooperM E, JenningsG L, JerumsG, NestelP J, O'BrienR C, SimonsL A, SullivanD

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Simvastatin was more effective than cholestyramine in lowering total and LDL cholesterol levels and the LDL/HDL ratio. Simvastatin also significantly increased HDL cholesterol levels, while cholestyramine increased triglyceride levels. Combined therapy further decreased total and LDL cholesterol levels and the LDL/HDL ratio. Simvastatin was better tolerated than cholestyramine.
Paper Details　
Original Abstract of the Article :
The effects of simvastatin, a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on plasma lipid levels were compared with those of the bile acid sequestrant cholestyramine in a randomized parallel study of 60 subjects with primary hypercholesterolaemia. After a 12-...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2199801

データ提供：米国国立医学図書館（NLM）

Simvastatin vs. Cholestyramine for Hypercholesterolaemia

This study explores the use of simvastatin and cholestyramine in treating primary hypercholesterolaemia, a condition that can increase the risk of cardiovascular disease. The researchers conducted a randomized parallel study to compare the effectiveness of these two medications in lowering cholesterol levels. The study provides valuable insights into the relative efficacy and safety of simvastatin and cholestyramine.

Simvastatin: A Promising Solution

The study reveals that simvastatin is more effective than cholestyramine in lowering total and LDL cholesterol levels. It's like discovering a new oasis in the desert of cholesterol management, offering a potentially more effective treatment option. The research also highlights the favorable impact of simvastatin on HDL cholesterol levels, further strengthening its potential benefits.

Navigating the Desert of Cholesterol Management

The study provides a clear roadmap through the desert of cholesterol management, offering guidance for choosing the most effective treatment approach. The research emphasizes the importance of considering both efficacy and safety when selecting a cholesterol-lowering medication.

Dr.Camel's Conclusion

This study highlights the potential benefits of simvastatin for treating hypercholesterolaemia. It's like finding a new source of water in a parched land, offering a potentially more effective and well-tolerated solution. While the research is promising, it's important to consult with a healthcare professional to determine the best treatment approach for individual needs.

Date :
  1. Date Completed 1990-09-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2199801

DOI: Digital Object Identifier

2199801

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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