Side Effects of cholestyramine resin: A Synthesis of Findings from 32 Studies

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Original Abstract of the Article

Main Research Findings

Cholestyramine is a medication used to treat high cholesterol, especially when diet alone is not effective. 11 It works by binding to bile acids in the gut, preventing their reabsorption and leading to a decrease in cholesterol levels. 20 Numerous studies have demonstrated the effectiveness of cholestyramine in treating high cholesterol. 19 4 6 5 3 2 16 23

Reasons for Side Effects

Cholestyramine's mechanism of action, binding to bile acids in the intestines to prevent cholesterol absorption, is also responsible for various side effects.

Common Side Effects

Gastrointestinal

Cholestyramine is known to cause gastrointestinal side effects. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23 The most common side effects are constipation, abdominal pain, and diarrhea. 19 28 21 22 25 24 31 16 14 Nausea, vomiting, and maldigestion have also been reported. 19 28 21 7 24 31 Cholestyramine can interfere with nutrient absorption in the intestines. 30 27

Others

Cholestyramine has also been linked to side effects beyond the gastrointestinal system. 17 24 30 These side effects may not affect all individuals taking cholestyramine, and their severity can vary.

Side Effects Management

Gastrointestinal

To prevent gastrointestinal side effects like constipation, it's essential to stay hydrated and consume a diet rich in fiber. 19 28 21 24 15 Since cholestyramine can worsen constipation, it's crucial to consult a physician for proper dosage. 19 28 21 24 If experiencing diarrhea or other gastrointestinal side effects, seek medical advice.

Others

Cholestyramine is absorbed and eliminated from the body within a few hours. 17 30 Therefore, when combining cholestyramine with other medications, it's essential to be mindful of the timing of administration. Cholestyramine can hinder the absorption of other drugs. 30

Comparison Between Studies

Similarities

Numerous studies have confirmed the effectiveness of cholestyramine in treating high cholesterol. 19 4 6 5 3 2 16 23 However, a common finding across these studies is the susceptibility of cholestyramine to cause gastrointestinal side effects. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23

Differences

The effectiveness and side effects of cholestyramine can vary across studies. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23 This likely stems from factors like the age, gender, weight, diet, and use of other medications in the study participants.

Real-World Application: Important Considerations

Cholestyramine is an effective treatment for high cholesterol, but its propensity for gastrointestinal side effects should be kept in mind. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23 When taking cholestyramine, it's crucial to adhere to the physician's instructions regarding the proper dosage. Consulting a doctor beforehand to ensure cholestyramine is suitable for your individual health is also important.

Current Research Limitations

The research on cholestyramine is still limited. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23 Therefore, more comprehensive research is necessary to gain a deeper understanding of cholestyramine's effects and side effects.

Future Research Directions

Further research is needed to thoroughly understand cholestyramine's effects and side effects. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23 For example, research on the combined effects of cholestyramine with other medications and the long-term impact of cholestyramine are crucial areas for investigation.

Conclusion

Cholestyramine is a medication effective in managing high cholesterol but is recognized for its tendency to cause gastrointestinal side effects. 11 20 19 28 21 7 17 4 6 5 3 15 22 25 13 12 24 31 29 9 2 27 16 14 30 18 23 It is essential to follow your doctor's instructions regarding the appropriate dosage. Additionally, before starting cholestyramine, consult your doctor to ensure it is a suitable option for your individual health profile.

Keywords
Benefit Keywords
L-thyroxine intoxication treatment
1
HDL-cholesterol increase
Hyperlipoproteinaemia treatment
2
Good tolerability
Reduced Apo B lipoprotein
Reduced LDL cholesterol
Reduced total cholesterol
3
Few side effects
Lowers cholesterol
4
Reduced cholesterol
5
Hypercholesterolemia treatment
6
Reduced plasma cholesterol
7
Increase HDL
Lower cholesterol
Lower triglycerides
8
Improved HDL
Lower cholesterol
Well tolerated
9
Increased HDL-C
Reduced LDL-C
Reduced total cholesterol
10
Reduced coronary events
11
Cholesterol lowering
12
LDL-C reduction
Total cholesterol reduction
13
Diarrhea treatment
14
Cholesterol reduction
Gastrointestinal side effect reduction
15
Improved clinical performance
Reduced lipid levels
16
Lipid-lowering effects
Safe and effective treatment
17
Lower CHD risk
18
Lowers LDL cholesterol
19
Cholesterol reduction
Improved lipid profile
20
Reduces burning and pruritus
21
Prevents diarrhea
22
Cholesterol Reduction
23
Hypercholesterolemia treatment
24
Diarrhea treatment
25
Hypocholesterolemic effect
Inhibition of cholesterol absorption
28
Hypercholesterolemia treatment
29
Effective diarrhea treatment
31
Diabetes treatment
Hypercholesterolemia treatment
Metabolic disorder treatment
Obesity treatment
32
Risk Keywords
Side effects
2
Mild side effects
7
Side effects
8
Increased triglycerides
9
Noncompliance
Treatment side effects
11
Occasional volume objection
12
Gastrointestinal side effects
Triglyceride increase
13
Lower physiological well-being
Myocardial infarction
16
Gastrointestinal side effects
Hepatic transaminases elevation
17
Constipation
Gastrointestinal discomfort
19
Gastrointestinal side-effects
Myalgia
20
Pelvic irradiation
Side effects
22
HDL Cholesterol Reduction
23
Gastrointestinal side effects
24
Gastrointestinal symptoms
Liver disease
Skin symptoms
26
Malabsorption
27
Gastrointestinal side effects
28
Nutrient deficiencies
Vitamin deficiencies
30
Digestive side effects
32
Literature analysis of 32 papers
Positive Content
29
Neutral Content
0
Negative Content
3
Article Type
9
0
0
2
32
1.

Light symptoms following a high-dose intentional L-thyroxine ingestion treated with cholestyramine.

Author: de LuisD A, DueñasA, MartinJ, AbadL, CuellarL, AllerR

L-thyroxine intoxication treatment

This case report describes the successful use of cholestyramine to treat a patient with L-thyroxine intoxication. Cholestyramine effectively reduced L-thyroxine levels and prevented the development of serious complications.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Decrease in LDL and increase in HDL concentrations in type II hyperlipoproteinaemic patients on low-dose combination therapy of cholestyramine and Complamin.

Author: FearsR, FerresH, HaackeH, MäderC, ParwareschM R

HDL-cholesterol increase
Hyperlipoproteinaemia treatment
Side effects

A combination of Complamin retard and cholestyramine was more effective in reducing cholesterol levels than either drug alone. The combination reduced total cholesterol by up to 35% and LDL cholesterol by up to 40% in patients with type IIa and IIb hyperlipoproteinemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

[Cholestyramine in the treatment of hypercholesterolemia. Our experience in 11 cases].

Author: MaízA, ArteagaA, VillanuevaC L, VelascoN, AcostaA M

Good tolerability
Reduced Apo B lipoprotein
Reduced LDL cholesterol
Reduced total cholesterol

Cholestyramine is an effective treatment for severe hypercholesterolemia, reducing total cholesterol, LDL cholesterol, and Apo B lipoprotein levels. It does not affect HDL cholesterol, Apo A1, or triglyceride levels and has no significant gastrointestinal side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Spanish

4.

High fiber diet in hyperlipemia. Comparison with cholestyramine treatment in type IIA hyperlipoproteinemia.

Author: PalumboP J, BrionesE R, NelsonR A

Few side effects
Lowers cholesterol

A high fiber diet was found to reduce serum cholesterol levels in patients with type IIa hyperlipoproteinemia, although the reduction was less pronounced than with cholestyramine treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

[Treatment of hypercholesterolemic patients of different age with simvastatin: 1-year study].

Author: PernigottiL, BoM, PoliL, ZanocchiM, FiandraU, PedrazziniV, FabrisF

Hypercholesterolemia treatment

Simvastatin was found to significantly reduce total and LDL cholesterol in both young (30-55 years) and elderly (60-75 years) patients with primary hypercholesterolemia, with no remarkable side effects in either group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

7.

Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial.

Author: ParkG D, SpectorR, KittT M

Reduced plasma cholesterol
Mild side effects

Superactivated charcoal and cholestyramine were both effective in lowering plasma cholesterol concentrations acutely. Superactivated charcoal reduced cholesterol by 21.8% compared to 16.2% for cholestyramine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

[Multicenter comparative study on safety, tolerance, and effectiveness of lovastatin combined or not with cholestyramine, and gemfibrozil combined or not with cholestyramine in the treatment of primary hypercholesterolemia].

Author: JoverE, ArandaJ L, NoguésX, del PalacioA, Rubiés-PratJ

Increase HDL
Lower cholesterol
Lower triglycerides
Side effects

Lovastatin was more effective than gemfibrozil in lowering total cholesterol and LDL-cholesterol in patients with primary hypercholesterolemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

9.

Comparison of simvastatin and cholestyramine in the treatment of primary hypercholesterolaemia.

Author: O'BrienR C, SimonsL A, CliftonP, CooperM E, JenningsG L, JerumsG, NestelP J, SullivanD

Improved HDL
Lower cholesterol
Well tolerated
Increased triglycerides

Simvastatin was more effective than cholestyramine in lowering total and LDL cholesterol levels and the LDL/HDL ratio. Simvastatin also significantly increased HDL cholesterol levels, while cholestyramine increased triglyceride levels. Combined therapy further decreased total and LDL cholesterol levels and the LDL/HDL ratio. Simvastatin was better tolerated than cholestyramine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

The single dose method of administering cholestyramine.

Author: CasdorphH R

Cholesterol lowering
Occasional volume objection

A new and simplified method for administering cholestyramine was found to be as effective as the traditional method.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Efficacy and compliance with cholestyramine bar versus powder in the treatment of hyperlipidemia.

Author: SweeneyM E, FletcherB J, RiceC R, BerraK A, RuddC M, FletcherG F, SuperkoR S

LDL-C reduction
Total cholesterol reduction
Gastrointestinal side effects
Triglyceride increase

Cholestyramine bar is as effective as cholestyramine powder in the treatment of hyperlipidemia, with comparable patient compliance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Cholestyramine therapy for quinidine-induced diarrhea. Case reports.

Author: RuDuskyB M

Diarrhea treatment

This study described seven patients experiencing quinidine-induced diarrhea that was successfully controlled by cholestyramine resin, suggesting it as a safe and effective treatment for this side effect.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Psyllium for the reduction of cholestyramine-associated gastrointestinal symptoms in the treatment of primary hypercholesterolemia.

Author: MaciejkoJ J, BrazgR, ShahA, PatilS, RubenfireM

Cholesterol reduction
Gastrointestinal side effect reduction

The study found that psyllium hydrophilic mucilloid (PHM) significantly reduced the frequency and severity of gastrointestinal side effects associated with cholestyramine therapy, such as constipation, abdominal discomfort, and heartburn. While PHM showed a tendency toward further reductions in total cholesterol and LDL-C levels, this effect did not reach statistical significance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Four years' treatment efficacy of patients with severe hyperlipidemia. Lipid lowering drugs versus LDL-apheresis.

Author: SchielR, BambauerR, MüllerU A

Improved clinical performance
Reduced lipid levels
Lower physiological well-being
Myocardial infarction

LDL-apheresis was more effective than diet and drug therapy in lowering lipid levels in patients with hyperlipidemia, and was associated with improved clinical performance but lower psychological well-being.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Abnormal low density lipoproteins in children with familial hypercholesterolemia--effect of polyanion exchange resins.

Author: MordasiniR, TwelsiekF, OsterP, SchellenbergB, RaetzerH, HeuckC C, SchlierfG

Lowers LDL cholesterol
Constipation
Gastrointestinal discomfort

Polyanion exchange resins were used to treat 20 children and adolescents with familial Type IIa hyperlipoproteinemia. The most common side effects were gastrointestinal discomfort and constipation. The resins reduced total and LDL cholesterol and Apo-B, but did not alter the abnormal LDL composition. HDL cholesterol remained low during treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia.

Author: WierzbickiA S, LumbP J, CheungJ, CrookM A

Cholesterol reduction
Improved lipid profile
Gastrointestinal side-effects
Myalgia

This study compared two combination therapies for severe familial hypercholesterolemia: simvastatin plus cholestyramine and simvastatin plus fenofibrate. The fenofibrate regimen was more effective in reducing total cholesterol, LDL cholesterol, and triglycerides, and also increased HDL cholesterol, compared to cholestyramine. However, gastrointestinal side effects were more common with cholestyramine, while myalgia was more common with fenofibrate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Evaluation of Cholestyramine 15% Ointment in Relieving Pruritus and Burning After Ileostomy: A Rrandomized, Double-Blind Placebo-Controlled Clinical Trial.

Author: AlaShahram, AlvandipourMina, SaeediMajid, SeyedeinSarvenaz, MonajatiMahila, KoulaeinejadNeda

Reduces burning and pruritus

This clinical trial evaluated the efficacy of topical cholestyramine in reducing burning and pruritus after an ileostomy. The results indicate that topical cholestyramine effectively managed burning and pruritus, with no reported side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

A clinical trial evaluating cholestyramine to prevent diarrhea in patients maintained on low-fat diets during pelvic radiation therapy.

Author: CharyS, ThomsonD H

Prevents diarrhea
Pelvic irradiation
Side effects

Cholestyramine was effective in preventing acute diarrhea induced by pelvic irradiation in patients receiving a low fat diet, but is associated with side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Effects of combination cholestyramine-neomycin treatment on plasma lipoprotein concentrations in type II hyperlipoproteinemia.

Author: HoegJ M, MaherM B, BaileyK R, ZechL A, GreggR E, SprecherD L, BrewerH B

Cholesterol Reduction
HDL Cholesterol Reduction

Combining cholestyramine and neomycin does not have an additive LDL cholesterol-lowering effect. Neomycin further reduces total cholesterol by decreasing high-density lipoprotein cholesterol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Efficacy of a combined bezafibrate retard-colestyramine treatment in patients with hypercholesterolemia.

Author: FischerS, HanefeldM, LangP D, FückerK, BergmannS, GehrischS, LeonhardtW, JarossW

Hypercholesterolemia treatment
Gastrointestinal side effects

Combined bezafibrate-colestyramine therapy is more effective than monotherapy with either drug in treating severe hypercholesterolemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

[Cholestyramine in the treatment of acute bacterial diarrhea in infants].

Author: Duffau ToroG, Emilfork SotoM, PrenzelI, UrbinaA M, MartínezA

Diarrhea treatment

Cholestyramine, in addition to the usual treatment regimen, improved the appearance of stools, decreased excretion of feces and water, and reduced sodium and potassium elimination in infants with infectious diarrhea and dehydration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

26.

Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis.

Author: TsuiLeo, ChenLiwei, YePeiying, XuShiling, WuSi-Jia, ChenSonia Chien-I, XieWei

Gastrointestinal symptoms
Liver disease
Skin symptoms

This study analyzed the adverse drug reactions (ADRs) of non-statin antihyperlipidaemic drugs in the China Anti-hyperlipidemic Drug Database. Gastrointestinal symptoms were the most common ADRs, particularly for fibrates, probucol, and cholestyramine. For nicotinic acid and derivatives, the ADRs of skin symptoms were the most common.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Drugs, alcohol and malabsorption.

Author: GreenP H, TallA R

Malabsorption

Alcohol and various medications can lead to malabsorption. Neomycin and cholestyramine, and factors contributing to malabsorption in chronic alcoholics are discussed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Selection of cholesterol absorption inhibitors devoid of secondary intestinal effects.

Author: MarquetF, Abou el FadilF, BoubiaB, GuffroyC, PansuD, Descroix-VagneM

Hypocholesterolemic effect
Inhibition of cholesterol absorption
Gastrointestinal side effects

A new cholesterol absorption inhibitor was synthesized with specific cholesterol absorption inhibition without secretory and deleterious effects, demonstrating the importance of amphiphilic characteristics in causing gastrointestinal side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

29.

Differentiated dosage of microporous colestyramine and its double-blind comparison with a placebo in hypercholesterolaemic patients.

Author: Di PerriT, FranchiM, BrunoM

Hypercholesterolemia treatment

Microporous colestyramine (MPC) was effective in reducing cholesterol levels in patients with hypercholesterolemia. It was well tolerated and effective in both the attack and maintenance phases of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

30.

Drug-nutrient interaction.

Author: MatsuiM S, RozovskiS J

Nutrient deficiencies
Vitamin deficiencies

Certain drugs were found to interfere with nutrient metabolism. Antituberculotic drugs, such as INH and cycloserine, interfere with vitamin B6 metabolism, while oral contraceptives interfere with the metabolism of folic acid, ascorbic acid, and riboflavin. Anticonvulsants can also interfere with folic acid metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

31.

[Prolonged diarrhea in infancy: effect of deconjugated bile acids and cholestyramine action].

Author: HeffesL A, LitwinN H, LicastroR, CervettoJ L

Effective diarrhea treatment

Cholestyramine was effective in treating acute diarrhea in children. 517 out of 527 patients showed satisfactory response. Side effects were not observed.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

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