Paper Details

  1. Home
  2. Paper Details

Tannate complexes of antihistaminic drug: sustained release and taste masking approaches.

Author: BerendtRobert T, KhanMansoor A, RahmanZiyaur, ZidanAhmed S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Complexation of brompheniramine maleate and tannic acid effectively sustained drug release and masked the bitter taste, making it suitable for pediatric use.
Paper Details　
Original Abstract of the Article :
The aim of this investigation was to evaluate the complexation potential of brompheniramine maleate (BPM) and tannic acid (TA) for sustained release and taste masking effects. The complexes (1:1-1:7 TA to BPM ratio) were prepared by the solvent evaporation method using methanol, phosphate buffer pH ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ijpharm.2011.10.033

データ提供：米国国立医学図書館（NLM）

Tannate Complexes: A Potential Oasis for Taste Masking and Sustained Release

The development of effective and palatable medications for children is a constant challenge in the realm of pharmaceutical science. This study explores the potential of tannate complexes as a novel approach to improve the taste and release profile of brompheniramine maleate (BPM), an antihistaminic drug. The researchers investigated the formation of complexes between BPM and tannic acid (TA) in various ratios, using different solvents. They then analyzed the characteristics of these complexes, focusing on their morphology, chemical interactions, thermal behavior, crystallinity, taste masking, and dissolution properties.

Tannate Complexes: A Promising Path Through the Desert of Drug Delivery

The study found that the tannate complexes effectively masked the bitter taste of BPM and significantly reduced its solubility, resulting in a sustained release of the drug over 24 hours. This suggests that tannate complexes have the potential to enhance the delivery of BPM, making it more palatable and effective for pediatric use.

Navigating the Desert of Drug Delivery: Seeking Safe and Effective Solutions

These findings are a promising step towards developing more palatable and effective medications for children. By exploring innovative approaches like tannate complexes, researchers are paving the way for a more patient-friendly experience with medications.

Dr.Camel's Conclusion

This study demonstrates the potential of tannate complexes as a novel approach to improve the taste and release profile of medications. This research highlights the importance of continuous innovation in drug delivery systems, especially for pediatric populations.

Date :
  1. Date Completed 2012-04-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22037447

DOI: Digital Object Identifier

10.1016/j.ijpharm.2011.10.033

Related Literature

Article Analysis
・Effects of brompheniramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.