Main Research Findings

Brompheniramine is a first-generation H1-receptor antagonist commonly used to alleviate allergy and cold symptoms. 23 , 11 . Brompheniramine has been shown to sensitize anti-cancer drug-resistant cells, such as 6 . Brompheniramine has been shown to affect the production of reactive oxygen species (ROS) both extracellularly and intracellularly in neutrophils, such as in 25 . Furthermore, brompheniramine has been linked to fixed drug eruptions caused by certain drugs, such as in 27 .

Brompheniramine has shown potential as a local anesthetic as demonstrated in 5 . It has been shown that brompheniramine is able to form inclusion complexes with beta-cyclodextrin, as shown in 19 .

Brompheniramine is widely used in children in the United States as indicated in 22 . The pharmacokinetics of brompheniramine in children between the ages of 2 to 17 years have been studied as demonstrated in 7 .

Brompheniramine has been shown to affect cardiac ion channels, as shown in 1 , and has been used for the development of sustained release formulations, as demonstrated in 15 .

Brompheniramine has been shown to modulate the metabolic activity of phagocytes, as shown in 16 , and has been shown to have antioxidant effects as demonstrated in . Brompheniramine has been used for enantiomeric separation by capillary electrophoresis, as shown in 12 .

Benefits and Risks

Benefit Summary

Brompheniramine is used to relieve allergy and cold symptoms. 23 . It may also have the potential to sensitize anti-cancer drug-resistant cells, as indicated in 6 . It can be used for the development of sustained release formulations, as demonstrated in 15 .

Risk Summary

Brompheniramine has the potential to cause side effects, as shown in 23 , and in children, specifically, it may cause respiratory issues as demonstrated in 2 .

Brompheniramine has been shown to modulate the metabolic activity of phagocytes, such as in 16 , which can be considered a potential risk.

Comparison Across Studies

Commonalities

All of these studies provide information about the pharmacological and toxicological properties of brompheniramine. These studies suggest that brompheniramine affects a variety of biological pathways.

Differences

These studies differ in the methodologies used to examine brompheniramine and in their focal points. Some studies have focused on the pharmacokinetics of brompheniramine while others have focused on the effects of brompheniramine on particular cells or tissues.

Consistency and Contradictions

Brompheniramine is a commonly used drug to relieve allergy and cold symptoms. 23 . However, some studies have suggested that brompheniramine can potentially cause dangerous side effects. For example, some studies have suggested that brompheniramine can affect cardiac ion channels, such as in 1 . There have also been studies indicating that brompheniramine can cause respiratory issues in children, such as in 2 .

Further research on the pharmacological and toxicological properties of brompheniramine is necessary, and future studies need to address these potential contradictions to fully understand the risks and benefits of brompheniramine.

Practical Implications

Brompheniramine is a commonly used drug to relieve allergy and cold symptoms. However, it is important to be aware of the potential side effects of brompheniramine. 23 . Brompheniramine can affect cardiac ion channels, as demonstrated in 1 , and people with heart conditions should talk to their doctor before taking brompheniramine.

Brompheniramine can cause respiratory issues in children, as shown in 2 , so it is important to talk to a doctor before giving brompheniramine to children.

Limitations

All of these studies provide information on brompheniramine; however, they all have certain limitations. For example, some studies are relatively small, and some studies are limited to specific populations.

Further research on brompheniramine is needed, and larger studies are necessary to better understand the safety and efficacy of brompheniramine.

Future Research Directions

Further research on brompheniramine is needed to better understand its safety and efficacy. In particular, it is necessary to examine the long-term effects of brompheniramine and its effects on diverse populations.

Furthermore, additional research is needed on the interactions of brompheniramine with other medications, and it is important to investigate new ways to safely use brompheniramine.

Conclusion

Brompheniramine is a commonly used drug to relieve allergy and cold symptoms, but it is important to be aware that brompheniramine can cause side effects. 23 . It is crucial to understand the risks and benefits before taking brompheniramine and to consult with a doctor. Further research on brompheniramine is needed, and larger studies are necessary to better understand the safety and efficacy of brompheniramine.