[Clinical study on combination of homoharringtonine, Ara-C and idarubicin induction for treatment of newly diagnosed acute myeloid leukemia patients].

Author: FangLi-Wei, HuNai-Bo, PanLi-Juan, QinTie-Jun, WangJing-Zhe, XiaoZhi-Jian, XuZe-Feng, ZhangHong-Li, ZhangYue

Paper Details 
Original Abstract of the Article :
The purpose of this study was to assess the efficacy and toxicity of HAI regimen [(homoharringtonine 2.5 mg/(m(2)×d), days 1 - 7; cytarabine 150 mg/(m(2)×d), days 1 - 7; idarubicin 9 mg/(m(2)×d), days 1 - 7)] for induction treatment of newly diagnosed acute myeloid leukemia (AML) (except acute promy...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/22040988

データ提供:米国国立医学図書館(NLM)

Treating Acute Myeloid Leukemia: A Multifaceted Approach

Acute myeloid leukemia (AML), like a relentless desert sandstorm, is a serious type of blood cancer. It requires aggressive treatment to achieve remission. This research explores the efficacy and toxicity of a new combination chemotherapy regimen (HAI) for the induction treatment of newly diagnosed AML, seeking a more effective and tolerable treatment approach.

HAI Regimen: A New Path in AML Treatment

The study, like a camel caravan venturing into uncharted territory, investigated the HAI regimen in 31 patients with AML. The results showed that the HAI regimen achieved a high complete remission (CR) rate, particularly after one course of induction. The CR rate varied depending on the patient's cytogenetics and initial white blood cell count, highlighting the need for personalized treatment approaches. The study also found that the HAI regimen was generally well-tolerated, with the most common side effect being severe infection. This research suggests that the HAI regimen could be a viable option for the treatment of newly diagnosed AML, offering a potentially more effective and tolerable approach.

Navigating AML Treatment: A Balance of Risks and Benefits

AML is a complex and challenging disease, and finding the right treatment approach is crucial. The HAI regimen shows promise, but it's important to weigh the potential benefits against the risks. Like a camel caravan navigating a treacherous desert, patients and their doctors must carefully consider all aspects of treatment, including the potential for side effects, to make informed decisions.

Dr. Camel's Conclusion

This study offers a promising new approach to the treatment of acute myeloid leukemia. The HAI regimen demonstrates a high complete remission rate, making it a potential alternative to standard chemotherapy regimens. However, it's important to note that this is a complex disease, and treatment decisions should be made on a case-by-case basis, considering the individual patient's needs and risk factors.

Date :
  1. Date Completed 2012-12-06
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

22040988

DOI: Digital Object Identifier

1009-2137(2011)05-1277-06

Related Literature

SNS
PICO Info
in preparation
Languages

Chinese

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