Paper Details

  1. Home
  2. Paper Details

A multicenter comparison of lovastatin and probucol for treatment of severe primary hypercholesterolemia. The Lovastatin Study Group IV.

Author:

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Lovastatin was found to be a more effective lipid-lowering agent than probucol in patients with severe primary hypercholesterolemia. Lovastatin was almost as effective when given in a single daily dose as when given in a divided dose. When given once a day, lovastatin was more effective if taken in the evening rather than the morning.
Paper Details　
Original Abstract of the Article :
A multicenter study was undertaken to compare the effects of lovastatin (given in 4 different dosage regimens) and probucol in patients with severe primary hypercholesterolemia. The subjects were 290 patients taking lipid-lowering diets who were randomly assigned to 1 of the following treatment regi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0002-9149(90)90437-6

データ提供：米国国立医学図書館（NLM）

Lovastatin vs. Probucol: A Race Through the Desert of Cholesterol

High cholesterol is a major risk factor for heart disease, a condition that can be as dangerous as a sandstorm. This study compares the effectiveness of lovastatin and probucol, two medications used to lower cholesterol levels. It's like a race through the desert, where each medication is vying for the best results in reducing cholesterol.

The study found that lovastatin was considerably more effective than probucol in reducing total cholesterol and low-density lipoprotein (LDL) cholesterol, the 'bad' cholesterol. Lovastatin also led to a significant increase in high-density lipoprotein (HDL) cholesterol, the 'good' cholesterol. Both medications were well-tolerated.

Lovastatin: A Powerful Weapon Against Cholesterol

This study highlights the effectiveness of lovastatin in reducing cholesterol levels, suggesting that it is a valuable tool for managing heart disease risk. The findings reinforce the importance of choosing the right medication to meet individual needs and achieve optimal cholesterol control.

Cholesterol Management: Navigating the Sands of Risk

High cholesterol is a major risk factor for heart disease. This study emphasizes the importance of effective cholesterol management to reduce heart disease risk. Like a desert traveler choosing the right path, we must choose the best medication for our individual needs and seek guidance from healthcare professionals.

Dr. Camel's Conclusion

This research compares the effectiveness of lovastatin and probucol in reducing cholesterol levels, highlighting lovastatin's superior performance in this 'race' through the desert of cholesterol. The study underscores the importance of effective cholesterol management to reduce heart disease risk.

Date :
  1. Date Completed 1990-10-19
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

2206033

DOI: Digital Object Identifier

10.1016/0002-9149(90)90437-6

Related Literature

Article Analysis
・Effects of lovastatin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.