Effects of lovastatin: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Major Research Findings

Lovastatin, a statin drug, has been extensively studied for its effects on lipid levels and cardiovascular health. 8 、 5 、 7 、 14 、 10 、 9 、 3 、 13 、 11 、 1 、 12 、 4 、 2 、 6 Research has shown that lovastatin effectively lowers LDL cholesterol levels (the bad cholesterol) and increases HDL cholesterol levels (the good cholesterol). 5 、 7 、 3 It also reduces triglyceride levels. 5 、 7 、 3 Moreover, lovastatin has been found to be safe and effective when used in combination with other lipid-lowering medications. 9 Lovastatin can be safely combined with antihypertensive medications. 9 The dosage of lovastatin needs to be adjusted based on individual patient characteristics. 10 、 3 、 4 Some studies suggest that lovastatin may have an impact on cognitive function. 14 、 1 However, a study comparing lovastatin and pravastatin found that while pravastatin had no effect on cognitive function, lovastatin was associated with cognitive decline. 1 Lovastatin may also affect sleep. 5 、 7 、 1 Side effects of lovastatin can include elevated liver enzymes and muscle pain. 2 、 10 These side effects can often be mitigated by adjusting the lovastatin dosage. 2 、 10 Long-term effects of lovastatin require further investigation. 13

Benefits and Risks

Benefit Summary

Lovastatin lowers LDL cholesterol and increases HDL cholesterol, potentially reducing the risk of heart disease and stroke. 5 、 7 、 3 It also lowers triglyceride levels. 5 、 7 、 3 13

Risk Summary

Lovastatin may cause side effects such as elevated liver enzymes and muscle pain. 2 、 10 Some studies suggest that lovastatin could potentially impact cognitive function and sleep. 14 、 1 Long-term effects of lovastatin require further investigation. 13

Study Comparison

Study Similarities

Multiple studies consistently demonstrate that lovastatin effectively lowers LDL cholesterol and raises HDL cholesterol levels. 5 、 7 、 3 The studies also show a reduction in triglyceride levels. 5 、 7 、 3 Furthermore, lovastatin maintains its effectiveness when used alongside other lipid-lowering medications. 9 9

Study Differences

The dosage of lovastatin varies across studies. 10 、 3 、 4 Studies show differing results regarding the impact of lovastatin on cognitive function and sleep. 14 、 1 The reported side effects of lovastatin also vary across studies. 2 、 10

Consistency and Discrepancies of Results

The consistent finding across studies is that lovastatin reduces LDL cholesterol and raises HDL cholesterol levels. 5 、 7 、 3 However, the findings regarding the effects of lovastatin on cognitive function and sleep are inconsistent. 14 、 1 Similarly, the reported side effects of lovastatin vary. 2 、 10 These discrepancies necessitate further research to clarify these aspects.

Application in Daily Life and Precautions

Lovastatin is a medication that can help lower cholesterol levels and potentially reduce the risk of heart disease and stroke. 13 However, it is important to be aware of potential side effects such as elevated liver enzymes and muscle pain. 2 、 10 Some research suggests potential impacts on cognitive function and sleep, though more investigation is needed. 14 、 1 Always consult with a healthcare professional before taking any medication, including lovastatin, and adhere to their instructions.

Limitations of Current Research

Long-term effects of lovastatin require further investigation. 13 Further research is also needed to clarify the impact of lovastatin on cognitive function and sleep. 14 、 1

Directions for Future Research

Further research is needed to assess the long-term effects of lovastatin. 13 Additional research is also crucial to determine the potential impact of lovastatin on cognitive function and sleep. 14 、 1

Conclusion

Lovastatin is a medication that has consistently been shown to effectively lower LDL cholesterol and raise HDL cholesterol levels, which may help reduce the risk of heart disease and stroke. 5 、 7 、 3 However, it's important to be aware of potential side effects and consult with a healthcare professional before taking lovastatin or any medication. 2 、 10 Further research is needed to fully understand the long-term effects and potential impact on cognitive function and sleep. 13 、 14 、 1

Literature analysis of 14 papers
Positive Content
13
Neutral Content
0
Negative Content
1
Article Type
13
1
0
0
14
1.

Comparative effects of pravastatin and lovastatin on nighttime sleep and daytime performance.

Author: RothT, RichardsonG R, SullivanJ P, LeeR M, MerlottiL, RoehrsT

Pravastatin for sleep
Lovastatin for performance

Lovastatin, but not pravastatin, significantly affected daytime performance in young, healthy men, suggesting a potential adverse effect on cognitive function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Clinical experience with lovastatin.

Author: TobertJ A, ShearC L, ChremosA N, MantellG E

Cholesterol decrease
Myopathy
Transaminase increase

Lovastatin is a safe and effective drug for long-term therapy. Side effects are rare, but can include myopathy, elevated transaminases, and skin rash.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A multicenter comparison of lovastatin and probucol for treatment of severe primary hypercholesterolemia. The Lovastatin Study Group IV.

Author:

Improved HDL
Lower cholesterol
Well tolerated

Lovastatin was found to be a more effective lipid-lowering agent than probucol in patients with severe primary hypercholesterolemia. Lovastatin was almost as effective when given in a single daily dose as when given in a divided dose. When given once a day, lovastatin was more effective if taken in the evening rather than the morning.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Expanded clinical evaluation of lovastatin (EXCEL) study: design and patient characteristics of a double-blind, placebo-controlled study in patients with moderate hypercholesterolemia.

Author: BradfordR H, ShearC L, ChremosA N, DujovneC, FranklinF A, HesneyM, HigginsJ, LangendörferA, PoolJ L, SchnaperH

Lower cholesterol

Lovastatin was found to be effective in lowering lipid levels in patients with moderately elevated cholesterol levels. The study also showed a dose-response relationship between lovastatin therapy and lipid modification.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Central nervous system effects of HMG CoA reductase inhibitors: lovastatin and pravastatin on sleep and cognitive performance in patients with hypercholesterolemia.

Author: KostisJ B, RosenR C, WilsonA C

Hypercholesterolemia treatment
Erectile dysfunction

This study compared the effects of lovastatin and pravastatin, two HMG-CoA reductase inhibitors, on sleep and cognitive performance in men with hypercholesterolemia. Neither drug significantly affected sleep parameters or cognitive performance. Both drugs significantly reduced total cholesterol, LDL cholesterol, and triglycerides.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of lovastatin in humans on biliary lipid composition and secretion as a function of dosage and treatment interval.

Author: DuaneW C

Reduced cholesterol levels

Lovastatin, a cholesterol-lowering drug, was found to be effective in reducing cholesterol secretion and saturation index in bile, with a recommended dose of 40 mg/day for the treatment or prevention of gallstones.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

[A comparison between lovastatin and pravastatin--effects on lipids, sleep and quality of life in primary hyperlipidemia].

Author: TonstadS, GørbitzC, OseL, MaltU F

Hyperlipidemia treatment
Adverse effects

This study compared the efficacy and safety of lovastatin and pravastatin in patients with hyperlipidemia. Both drugs effectively reduced LDL-cholesterol levels and were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Norwegian

8.

Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial.

Author: IllingworthD R, SteinE A, MitchelY B, DujovneC A, FrostP H, KnoppR H, TunP, ZupkisR V, GreguskiR A

Effective for hypercholesterolemia

This study compared the lipoprotein-modifying effects and safety of lovastatin and niacin in patients with hypercholesterolemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effect and tolerability of combining lovastatin with nifedipine or lisinopril.

Author: OsI, BratlandB, DahlöfB, GisholtK, SyvertsenJ O, TretliS

Lowers cholesterol
Safe combination therapy
Increased liver enzymes

Lovastatin, when combined with lisinopril or nifedipine for the treatment of mild to moderate hypertension, effectively lowered cholesterol levels without adversely affecting the antihypertensive effects of either drug. The combination was well-tolerated and did not cause any more adverse effects than the antihypertensive agents alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Efficacy of three statins at lower maintenance doses.

Author: Carr-LopezS, ExstrumT, MorseT, ShepherdM, BushA C

Lipid control
Side effects

This study investigated whether patients stable on lovastatin 20 mg daily could be switched to lower daily doses of lovastatin, pravastatin, or simvastatin without loss of lipid control or an increase in side effects. Patients switched to pravastatin 10 mg or simvastatin 5 mg daily maintained lipid control, while those switched to lovastatin 10 mg experienced an increase in total cholesterol levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

The effect of aggressive and moderate lowering of LDL-cholesterol and low dose anticoagulation on plasma lipids, apolipoproteins and lipoprotein families in post coronary artery bypass graft trial.

Author: AlaupovicP, FesmireJ D, HunnighakeD, DomanskiM, FormanS, KnatterudG L, ForresterJ, HerdJ A, HoogwerfB, CampeauL, GobelF L

Reduced atherosclerosis progression
None mentioned

Aggressive lowering of LDL cholesterol was more effective than moderate lowering in reducing the progression of atherosclerosis in saphenous-vein grafts. Lovastatin treatment, either aggressive or moderate, significantly decreased the levels of various lipid and lipoprotein parameters.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide.

Author: FriedhoffL T, CullenE I, GeoghagenN S, BuxbaumJ D

Lower A beta production

Beta-amyloid (A beta) buildup in the brain is thought to be central to the development of Alzheimer’s disease. Previous studies have shown that lovastatin, a cholesterol-lowering drug, can reduce A beta production in lab settings. This study investigated the effect of lovastatin on A beta levels in living subjects. Individuals with high cholesterol levels were randomly given either lovastatin or placebo for up to 3 months. A dose-dependent decrease in serum A beta levels was observed, with statistically significant differences between the higher lovastatin doses and placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

Clinical implications of statin event trials.

Author: GoldbergAnne Carol

Reduced cardiovascular events

This study reviews the evidence for the efficacy and safety of statin therapy in preventing cardiovascular events. The study found that statins have shown generally similar effects on reducing cardiovascular events and are considered safe for long-term treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

14.

Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults.

Author: MuldoonMatthew F, RyanChristopher M, SereikaSusan M, FloryJanine D, ManuckStephen B

Cognitive impairment

This study investigated the effects of lovastatin, a cholesterol-lowering drug, on cognitive function. Lovastatin was found to have negative effects on cognitive performance in some areas.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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