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Outcomes on the pharmacopsychometric triangle in bupropion-SR vs. buspirone augmentation of citalopram in the STAR*D trial.

Author: BechP, FavaM, RushA J, TrivediM H, WisniewskiS R

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study compared the effectiveness of bupropion and buspirone as augmentation treatments for major depression.
Paper Details　
Original Abstract of the Article :
To compare within the framework of a novel pharmacopsychometric triangle, augmentation treatment with bupropion vs. buspirone in the acute therapy of major depression in the STAR*D study. The triangle provides a composite view in three domains of antidepressive activity, side effects, and quality of...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0447.2011.01791.x

データ提供：米国国立医学図書館（NLM）

Treating Depression: A Triangular Approach

Major depressive disorder is a complex and debilitating condition that significantly impacts quality of life. This study investigates the effectiveness of two augmentation therapies, bupropion and buspirone, in treating major depression. The researchers used the STAR*D trial, a large-scale clinical trial, to compare the effects of these therapies within the framework of a novel "pharmacopsychometric triangle." This framework considers three domains of antidepressant activity: side effects, quality of life, and antidepressive efficacy. The study found that both bupropion and buspirone were effective in augmenting treatment response in patients with major depression, but they differed in their effects on side effects and quality of life. This study provides valuable insights into the differential effects of augmentation therapies, offering guidance for tailoring treatment strategies to individual patient needs.

Optimizing Depression Treatment: Choosing the Right Path

The study highlights the importance of considering not only the effectiveness of treatment but also its impact on side effects and quality of life. It suggests that different augmentation therapies may be more suitable for certain patients based on their individual needs and preferences.

A Personalized Approach to Depression Treatment

This research underscores the need for a personalized approach to depression treatment. It encourages clinicians to consider the individual patient's needs, including potential side effects and their impact on quality of life, when choosing the most appropriate treatment options.

Dr.Camel's Conclusion

This study is like a map guiding us through the complex landscape of depression treatment, highlighting the importance of considering multiple factors beyond just efficacy. The pharmacopsychometric triangle provides a valuable framework for understanding the multifaceted nature of depression treatment and making informed choices for individual patients.

Date :
  1. Date Completed 2012-06-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22077211

DOI: Digital Object Identifier

10.1111/j.1600-0447.2011.01791.x

Related Literature

Article Analysis
・Side Effects of buspirone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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