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[Effectiveness of nifedipine, diltiazem and their combination in the treatment of chronic stable angina pectoris].

Author: KoukalováH, LupínekZ, MeluzínJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effectiveness of nifedipine, diltiazem, and a combination of both medications in treating stable angina in 25 patients. Both nifedipine and diltiazem improved exercise tolerance, reduced chest pain frequency, and decreased the need for nitroglycerin. Diltiazem was more effective than nifedipine in increasing exercise tolerance and delaying the onset of chest pain. Combining nifedipine and diltiazem did not improve outcomes compared to diltiazem alone, and the combination was poorly tolerated by most patients. The study concludes that diltiazem is a more effective and well-tolerated treatment for stable angina compared to nifedipine, and that combining these medications does not offer significant benefits.
Paper Details　
Original Abstract of the Article :
In a double blind crossed ten-week study with a randomized beginning the authors compared in 25 patients with chronic stable angina pectoris (II-III according to NYHA classification) and with normal blood pressure the effect of placebo, nifedipine, diltiazem and in 16 of the patients (who completed ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2208231

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1990-11-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2208231

DOI: Digital Object Identifier

2208231

Related Literature

Article Analysis
・Effective treatment of angina
SNS
PICO Info
in preparation
Languages

Czech

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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