Effective treatment of angina: A Synthesis of Findings from 68 Studies

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Original Abstract of the Article

Major Research Findings

There are two main approaches to treating angina: medication and revascularization. Medication aims to relieve angina symptoms and reduce the risk of heart attacks. Revascularization uses methods such as stents or bypass surgery to improve blood flow to the heart.

Some studies have shown that drugs such as beta-blockers, calcium channel blockers, and nitrates can improve angina symptoms and increase exercise tolerance. 8 , 65 , 9 , 63 , 1 , 26 , 22 On the other hand, revascularization is a viable option for patients who do not respond to medication or whose blood flow to the heart is severely blocked. 46 , 3 , 52 , 59

Some studies suggest that certain drugs may be more effective than others. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 However, these studies are each conducted with different designs and participant populations, so it is difficult to generalize these findings.

Treatment Summary

Treatment for angina is based on two primary approaches: medication and revascularization.

8 recommends a combination therapy of nitrates, beta-blockers, calcium antagonists, anticoagulants, and platelet anti-aggregates for angina treatment.

13 indicates that nitrates are effective for treating angina, but continuous nitrate therapy may experience a reduction in effectiveness, so incorporating nitrate-free intervals is recommended.

65 categorizes drugs used in angina treatment into first-line drugs (beta-blockers, calcium channel blockers, short-acting nitrates) and second-line drugs (long-acting nitrates, ivabradine, nicorandil, ranolazine, and trimetazidine). However, limited comparative data exists between these drug classes, making it inconclusive which is superior.

46 asserts that revascularization is essential in treating angina. Revascularization methods include coronary artery bypass surgery and percutaneous coronary intervention (PCI). PCI is a treatment that uses stents to expand narrowed coronary arteries.

56 presents trimetazidine as an effective drug for treating angina. Trimetazidine is believed to suppress myocardial ischemia by altering intracellular metabolism.

Benefits and Risks

Benefits Summary

Angina treatment can alleviate symptoms and reduce the risk of heart attacks. 8 , 11 , 32 , 68 Revascularization is a viable option for patients who do not respond to medication or whose blood flow to the heart is severely blocked. 46 , 3 , 52 , 59 Angina treatment can also potentially improve quality of life.

Risks Summary

Medication can cause side effects. 13 , 56 , 34 , 64 Revascularization carries risks associated with surgery and complications. 46 , 3 , 52 , 59

Comparison Between Studies

Commonalities in Research

Many studies indicate the effectiveness of medication and revascularization in treating angina. 8 , 46 , 3 Additionally, many studies demonstrate the effectiveness of medication in relieving angina symptoms and reducing the risk of heart attacks. 8 , 65 , 9 , 63 , 1 , 26 , 22

Differences in Research

Research varies in terms of drugs and treatments used, participant populations, and study design. Consequently, directly comparing research findings is difficult. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 Moreover, while some studies suggest that certain drugs are more effective than others, other studies do not find such results. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 These discrepancies may stem from differences in research design and participant populations.

Consistency and Contradictions in Findings

Research findings regarding angina treatment show consistency while also presenting contradictions. 8 , 46 , 3 Many studies indicate the effectiveness of medication and revascularization in treating angina. 8 , 46 , 3 However, research findings on the effectiveness of specific drugs and treatments may not align. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 These discrepancies may stem from variations in research design and participant populations.

Cautions for Real-World Application

Angina treatment should be selected on an individual basis, taking into account the patient's symptoms and medical conditions. 8 , 46 , 3 Treatment effectiveness varies from person to person. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 Consequently, consulting with a doctor is crucial before commencing treatment.

Limitations of Current Research

Research on angina treatment remains inadequate. 8 , 46 , 3 In particular, the long-term effectiveness of specific drugs and treatments is still not fully understood. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 Additionally, research findings may vary due to differences in research design and participant populations.

Future Research Directions

Further research on angina treatment is necessary. 8 , 46 , 3 In particular, research evaluating the long-term effectiveness and safety of specific drugs and treatments is crucial. 34 , 64 , 60 , 5 , 6 , 31 , 24 , 30 , 16 , 57 , 21 , 3 , 66 , 67 Developing treatments that improve patient quality of life is also important.

Conclusion

Angina is a common symptom of heart disease, and there are two primary approaches to treating it: medication and revascularization. 8 , 46 , 3 Many studies show that medication is effective in relieving angina symptoms and reducing the risk of heart attacks. 8 , 65 , 9 , 63 , 1 , 26 , 22 Revascularization is a viable option for patients who do not respond to medication or whose blood flow to the heart is severely blocked. 46 , 3 , 52 , 59 Angina treatment should be chosen on a case-by-case basis, tailored to the individual patient's symptoms and medical conditions. 8 , 46 , 3 Consulting with a doctor before starting treatment is essential.

Treatment List

Nitrates, beta-blockers, calcium channel blockers, anticoagulants, platelet anti-aggregates, ivabradine, nicorandil, ranolazine, trimetazidine, stents, coronary artery bypass surgery

Keywords
Benefit Keywords
Angina treatment
Improved exercise performance
1
Improved exercise tolerance
2
Angina relief
3
Angina relief
Prevention of ischemia
4
Angina reduction
Exercise tolerance
5
Angina relief
6
Angina treatment
7
Decreased incidence of myocardial infarction
Decreased incidence of refractory angina
Improved survival
Symptomatic relief
8
Angina treatment
9
Myocardial ischaemia treatment
10
Angina treatment
11
Unstable angina treatment
12
Improved exercise tolerance
Reduced frequency of angina
13
Improved exercise tolerance
Reduced angina frequency
Reduced nitroglycerin consumption
14
Effective for angina
Well tolerated
15
Delayed stenocardia
Improved work tolerance
Reduced nitroglycerin use
16
Improved exercise tolerance
Reduced angina attacks
17
Angina reduction
18
Angina reduction
19
Angina relief
20
Angina reduction
ST segment depression reduction
21
Angina treatment
22
Atenolol efficacy
Nocturnal ischemia reduction
23
Angina treatment
24
Unstable angina treatment
25
Reduced anginal attack rate
Reduced trinitrate requirements
26
Atenolol effective
Labetalol effective
27
Angina pectoris treatment
28
Angina pectoris treatment
29
Unstable angina treatment
30
Reduced angina pectoris
Reduced ischemic ST-segment depression
31
Improved work capacity
32
Improved work capacity
33
Reduced pain episodes
34
Improved heart function
Reduced angina
35
Reduced anginal attacks
Reduced nitroglycerin consumption
36
Effective angina treatment
Similar effects to propranolol
37
Reduced angina frequency
Reduced nitroglycerin use
38
Increased working capacity
Reduced angina
39
Reduced angina frequency
40
Angina treatment
41
Suppressed asymptomatic cardiac ischemia
42
Effective for stable angina
Platelet anti-aggregant effect
Well tolerated
43
Improved angina symptoms
Long-lasting effect
45
Improved unstable angina treatment
46
Symptomatic improvement
47
Angina treatment
Improved control
50
UCAD treatment
51
Freedom from major adverse events
Freedom from repeat revascularization
52
Reduced need for angiogram
Reduced need for intervention
53
Control angina symptoms
54
Risk score for angina
55
Cost-effective treatment
Improved stable angina treatment
Reduced adverse effects
56
No clinically relevant differences
Similar effects on TET
57
Improved clinical situation
58
CABG angina relief
59
Ranolazine
60
Treat refractory angina
61
Stable angina treatment
62
Improved chronic stable angina treatment
63
Coronary artery treatment
Ranolazine
64
First and second line treatment
Stable angina treatment
65
Angina improvement
MACE reduction
Mortality reduction
66
Acupuncture
67
Clopidogrel for acute angina
68
Risk Keywords
Asthenia
Leg fatigue
1
Surgical mortality
3
Heart failure
4
Bradycardia
7
Side effects
10
Bleeding complications
11
Headache with isosorbide dinitrate
14
Headache with isosorbide dinitrate
15
Side effects
Treatment termination
16
Cardiovascular events
17
Headache
19
Dyspnea
28
Increased heart rate
31
Drug side effects
45
Procedure-related complications
47
Adverse cardiovascular outcome
49
Increased peripheral revascularization
53
Stable angina
56
Headache
57
PCI revascularization
59
Chronic angina pectoris
60
Literature analysis of 68 papers
Positive Content
64
Neutral Content
3
Negative Content
1
Article Type
56
9
8
6
68
1.

Atenolol in the treatment of angina pectoris.

Author: ErikssenJ, OsvikK, DedichenJ

Angina treatment
Improved exercise performance
Asthenia
Leg fatigue

Atenolol, a beta-blocker, significantly reduced heart rate and blood pressure at rest and during exercise in 19 patients with stable angina pectoris. Higher doses (100 mg) did not significantly improve physical performance compared to lower doses (50 mg). Sixteen patients had better bicycle exercise performance on atenolol than on placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Comparative effects of nifedipine, verapamil, isosorbide dinitrate and propranolol on exercise-induced angina pectoris.

Author: de PontiC, MauriF, CilibertoG R, CarùB

Improved exercise tolerance

A study of 5 patients with stable-effort angina compared the effects of isosorbide dinitrate (ISDN), propranolol (Pr), nifedipine (N), verapamil (V), and placebo on exercise tolerance. All active treatments increased the duration of exercise before ECG changes. ISDN, N, and V significantly increased both the duration and total work performed before angina, while Pr showed no significant improvement. ISDN, N, and V were more effective than Pr in improving exercise performance before angina. ISDN and N were more effective than Pr in delaying ECG changes. While all treatments affected heart rate, blood pressure, ejection time, and triple product, ISDN, N, and V allowed patients to perform the same work with a lower triple product compared to Pr.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Unstable angina pectoris: a randomized study of patients treated medically and surgically.

Author: PughB, PlattM R, MillsL J, CrumboD, PolinerL R, CurryG C, BlomqvistG C, ParkeyR W, BujaL M, WillersonJ T

Angina relief
Surgical mortality

A study of 50 patients with unstable angina found that: - 16% had significant left main coronary artery disease, while 10% had no significant coronary artery disease. - Surgical treatment provided better pain relief, but there was no significant difference in 1.5-year survival rates between surgically treated and medically treated patients. - 50% of medically treated patients experienced recurrent unstable angina within the first few months of follow-up. - The mortality rate for patients with unstable angina and left main coronary artery disease was high (43%). - Four out of six patients with inoperable unstable angina died within a few months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Treatment of spontaneous angina pectoris with beta blocking agents. A clinical, electrocardiographic, and haemodynamic appraisal.

Author: GuazziM, FiorentiniC, PoleseA, MagriniF, OlivariM T

Angina relief
Prevention of ischemia
Heart failure

A study of 36 patients with daily spontaneous angina found that both propranolol and practolol were effective in reducing angina episodes, but propranolol was more effective in patients with ST segment elevation. The effectiveness of both drugs was dose-dependent, and patients responded differently to each drug. While propranolol was more effective for ST segment elevation, both drugs effectively prevented ischemia and did not cause significant heart failure. The study suggests that the antianginal effect may be independent of beta-blockade and may be related to changes in coronary blood vessel function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Antianginal and anti-ischemic efficacy of nicorandil compared with nifedipine in patients with angina pectoris and coronary heart disease: a double-blind, randomized, multicenter study.

Author: UlvenstamG, DiderholmE, FrithzG, GudbrandssonT, HedbäckB, HöglundC, MoelstadP, PerkJ, SverrissonJ T

Angina reduction
Exercise tolerance

A study of 58 patients with stable angina compared the effects of nicorandil and nifedipine. Both drugs significantly reduced angina attacks, increased exercise duration, and delayed the onset of angina and ST depression. Nicorandil was more effective at the higher dose (20 mg twice daily). While nifedipine significantly reduced both systolic and diastolic blood pressure and heart rate, nicorandil only significantly reduced resting systolic blood pressure at the higher dose. Overall, both drugs were effective in treating angina, but there was no significant difference between the two.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

[Anti-angina effect of amiodarone in therapy-resistant angina pectoris].

Author: MeyerB J, GschwendS, MarxB, AmannF W

Angina relief

A study of 63 patients with stable angina found that amiodarone, in addition to standard medications (nitrates, beta-blockers, and calcium channel blockers), significantly improved exercise duration and reduced heart workload (double product) and ST-segment depression. The study suggests that amiodarone is an effective treatment for patients with limited angina who are already on conventional medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

7.

[Comparison of the effects of diltiazem and isradipine in adrenergic beta receptor blockade in patients with stable angina pectoris].

Author: MeluzínJ, NovákM

Angina treatment
Bradycardia

A study of 20 patients with stable angina found that both diltiazem and isradipine, when combined with a beta-blocker (metipranolol), were more effective in reducing angina symptoms and improving exercise tolerance compared to placebo. Isradipine was considered safer than diltiazem because metipranolol prevented the increase in heart rate often seen with isradipine and also reduced the risk of side effects. While diltiazem can be effective, it should be used with caution due to the risk of severe bradycardia. The study concluded that isradipine combined with metipranolol is a safer and more effective treatment option for stable angina compared to diltiazem or monotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Czech

8.

[Unstable angina: from physiopathology to therapeutics].

Author: AntonyI, ValèreP E

Decreased incidence of myocardial infarction
Decreased incidence of refractory angina
Improved survival
Symptomatic relief

Unstable angina is a complex syndrome with various presentations. Treatment involves multiple drugs to reduce the risk of heart attack and death, and thrombolytic therapy is being studied. Coronary angioplasty or bypass surgery may be considered when medical therapy fails.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : French

9.

Efficacy of nifedipine and isosorbide mononitrate in combination with atenolol in stable angina.

Author: AkhrasF, JacksonG

Angina treatment

Adding calcium-channel blockers and/or nitrates to beta-blocker therapy for angina did not offer a significant advantage over beta-blockers alone. However, adding isosorbide mononitrate slightly improved exercise tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Open comparative study to assess the efficacy and safety of two calcium antagonists, amlodipine and diltiazem, in the treatment of symptomatic myocardial ischaemia.

Author: CaponnettoS, CanaleC, TerrachiniV, MasperoneM A, BruzzoneF

Myocardial ischaemia treatment
Side effects

This study compared the effectiveness of amlodipine and diltiazem in treating patients with chest pain caused by heart problems. Both drugs effectively reduced the frequency of chest pain and the need for nitroglycerin. Amlodipine more effectively reduced pressure in the heart. Both drugs were well-tolerated, but side effects were more common with diltiazem, especially at higher doses. Overall, amlodipine was considered more effective than diltiazem for treating chest pain. The study highlights the effectiveness of amlodipine, which can be taken once daily, in managing heart problems.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Effect of heparin, aspirin, or alteplase in reduction of myocardial ischaemia in refractory unstable angina.

Author: Neri SerneriG G, GensiniG F, PoggesiL, TrottaF, ModestiP A, BoddiM, IeriA, MargheriM, CasoloG C, BiniM

Angina treatment
Bleeding complications

In a study of 97 patients with unstable angina, heparin infusion was more effective than heparin bolus or aspirin in reducing angina frequency, silent ischemia, and overall ischemia duration. Alteplase showed only minor benefits. Minor bleeding complications were noted.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Medical management of unstable angina. What have we learned from the randomized trials?

Author: LubsenJ

Unstable angina treatment

This review discusses the treatment of unstable angina, highlighting the importance of considering the timing and context of treatment when interpreting clinical trials. The study found that in patients admitted to the hospital with suspected unstable angina, beta-blockers were more effective than calcium channel blockers in preventing heart attacks or worsening chest pain. However, adding a calcium channel blocker was beneficial for patients who remained unstable despite taking a beta-blocker. This suggests that beta-blockers should be the initial treatment for unstable angina, and calcium channel blockers can be added if needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Angina: evolution of the role of nitrates.

Author: ScheidtS

Improved exercise tolerance
Reduced frequency of angina

Continuous nitroglycerin therapy for angina may not improve exercise tolerance, while intermittent therapy with nitrate-free intervals improves both exercise tolerance and clinical angina. The optimal duration of the nitrate-free interval is unknown.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

[Comparison of the effects of depot isosorbide dinitrate (Isoket Retard 120) and diltiazem in patients with exertional angina pectoris].

Author: MeluzínJ, LupínekZ, LupínkováZ

Improved exercise tolerance
Reduced angina frequency
Reduced nitroglycerin consumption
Headache with isosorbide dinitrate

This study compared the effects of diltiazem and isosorbide dinitrate in 13 patients with stable angina. Both medications improved exercise tolerance and reduced the frequency of chest pain. Diltiazem was more effective in lowering heart rate and blood pressure. While both drugs were effective, diltiazem was better tolerated, while isosorbide dinitrate caused frequent headaches.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Czech

15.

[Comparison of antianginal effects of diltiazem and metoprolol in patients with ischemic heart disease with different clinical forms of angina pectoris].

Author: GulievA B, SidorenkoB A, LupanovV P, KrutovskikhI V, IaroshevskaiaF M

Effective for angina
Well tolerated
Headache with isosorbide dinitrate

This study compared the effectiveness of diltiazem and metoprolol in treating chest pain (angina) in 64 patients. Both medications were effective in reducing chest pain caused by exercise, with diltiazem showing a slightly higher success rate (74% vs. 62%). However, diltiazem was more effective than metoprolol in treating chest pain that occurred without exercise (85.7% vs. 50%). The study suggests that diltiazem may be a more versatile treatment option for chest pain compared to metoprolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

16.

[Effectiveness of nifedipine, diltiazem and their combination in the treatment of chronic stable angina pectoris].

Author: MeluzínJ, LupínekZ, KoukalováH

Delayed stenocardia
Improved work tolerance
Reduced nitroglycerin use
Side effects
Treatment termination

This study compared the effectiveness of nifedipine, diltiazem, and a combination of both medications in treating stable angina in 25 patients. Both nifedipine and diltiazem improved exercise tolerance, reduced chest pain frequency, and decreased the need for nitroglycerin. Diltiazem was more effective than nifedipine in increasing exercise tolerance and delaying the onset of chest pain. Combining nifedipine and diltiazem did not improve outcomes compared to diltiazem alone, and the combination was poorly tolerated by most patients. The study concludes that diltiazem is a more effective and well-tolerated treatment for stable angina compared to nifedipine, and that combining these medications does not offer significant benefits.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Czech

17.

Controlled clinical trial of bepridil, propranolol and placebo in the treatment of exercise induced angina pectoris. B.I.S. Research Group.

Author: DestorsJ M, BoisselJ P, PhilipponA M, SchbathJ

Improved exercise tolerance
Reduced angina attacks
Cardiovascular events

A study of 191 patients with exercise-induced angina found that bepridil, propranolol, and placebo all reduced the frequency of angina attacks by 49-77% over 6 months. While bepridil showed early improvement in angina severity and exercise tolerance compared to placebo, these differences disappeared by week 24. Bepridil had a lower rate of severe angina leading to study withdrawal compared to placebo and propranolol. However, one patient died in the bepridil group, compared to none in the placebo group. There were fewer severe cardiovascular side effects in the bepridil group compared to the propranolol group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Superior efficacy of propranolol versus nifedipine in double-component angina, as related to different influences on coronary vasomotility.

Author: DeCesareN, BartorelliA, FabbiocchiF, FolliA, LoaldiA, MontorsiP, PoleseA, GuazziM D

Angina reduction

This study investigated the cause of chest pain (angina) at rest in 24 patients with stable heart disease. The study found that these episodes were not preceded by changes in heart rate or blood pressure that would increase the heart's oxygen demand. This suggests that the chest pain was caused by temporary blockage of blood flow in a narrowed coronary artery. The study also evaluated the effectiveness of nifedipine and propranolol in treating this condition.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

[Comparison of isosorbide dinitrate and nifedipine in the treatment of variant angina pectoris. Randomized study].

Author: AschermannM, BultasJ, KaretováD, KölbelF, SimperD, KozákováM

Angina reduction
Headache

This study compared the effectiveness of isosorbide dinitrate and nifedipine in 17 patients with variant angina (chest pain caused by spasms in coronary arteries). Both treatments significantly reduced the number of angina attacks and episodes of ST-segment changes on heart monitoring, both with and without symptoms. Patients also showed improved exercise tolerance. While both medications were effective, three patients experienced severe headaches with isosorbide dinitrate and had to stop the medication. The study concludes that both isosorbide dinitrate and nifedipine are effective treatments for variant angina, but patients should be aware of the potential for headaches with isosorbide dinitrate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Czech

20.

The efficacy of the addition of nifedipine in patients with mixed angina compared to patients with classic exertional angina: a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Author: StoneP H, WareJ H, DeWoodM A, GoreJ M, EichR H, PietroD A, ParisiA F, NestoR W, BodenW E, SharmaS C

Angina relief

This study investigated the effectiveness of adding nifedipine to existing treatments for angina in 72 patients with stable chest pain. Patients were categorized as having either “classic exertional angina” (stable chest pain triggered by exercise) or “mixed angina” (chest pain triggered by varying levels of exercise and/or at rest). The study found that nifedipine was more effective in reducing chest pain and medication use in patients with mixed angina compared to those with classic exertional angina. While both groups showed improved exercise tolerance, only patients with mixed angina had a reduction in the frequency of silent heart attacks during nifedipine treatment. The study suggests that patients with mixed angina may benefit more from nifedipine, but that other factors besides coronary artery spasms may contribute to their chest pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effect of pharmacologic therapy on angina frequency, ST segment depression during ambulatory ECG monitoring, and treadmill performance in patients with chronic stable mild angina.

Author: KawanishiD T, ReidC L, SimsarianG, AmisolaY, GonzalesA, RahimtoolaS H

Angina reduction
ST segment depression reduction

This study examined the effectiveness of propranolol and nifedipine in treating 15 patients with mild, stable angina. Both medications significantly reduced the frequency of episodes of ST-segment depression (a sign of heart problems) on 24-hour heart monitoring, both with and without symptoms. The number of patients experiencing ST-segment depression decreased significantly with treatment. While there was a non-significant increase in exercise time and a slight decrease in maximum heart rate, the number of patients experiencing chest pain during exercise also decreased. The study concludes that both propranolol and nifedipine effectively reduce the signs and symptoms of angina.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Atenolol with and without nifedipine in the treatment of angina pectoris. Preliminary report.

Author: SandbergM, FoaleR A

Angina treatment

This study compared the effectiveness of atenolol alone to a combination of atenolol and nifedipine in treating 94 patients with stable angina. All treatments reduced the frequency of angina attacks and the need for nitroglycerin. The combination therapy showed greater improvement in exercise tolerance, with a significant reduction in ST segment depression during exercise compared to atenolol alone. The combination therapy also resulted in a higher proportion of patients who were pain-free after treatment. While both treatments were well-tolerated, the study concludes that combining atenolol and nifedipine may offer a more effective treatment for stable angina.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Medical treatment of patients with severe exertional and rest angina: double blind comparison of beta blocker, calcium antagonist, and nitrate.

Author: QuyyumiA A, CrakeT, WrightC M, MockusL J, FoxK M

Atenolol efficacy
Nocturnal ischemia reduction

This study investigated the effectiveness of three medications in treating nine patients with both exercise-induced and resting chest pain (angina). The study found that atenolol was most effective in reducing heart rate, blood pressure, and the severity of heart problems during exercise. Atenolol also significantly reduced the number and duration of heart problems during overnight monitoring and reduced the incidence of chest pain. Nifedipine and isosorbide mononitrate were less effective than atenolol. The study concludes that atenolol is the most effective treatment for both exercise-induced and resting angina in patients with severe coronary artery disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Relation of antianginal efficacy of nifedipine to degree of coronary arterial narrowing and to presence of coronary collateral vessels.

Author: SchulzW, JostS, KoberG, KaltenbachM

Angina treatment

A study of 36 patients with angina compared the effects of nifedipine, isosorbide dinitrate, a combination of both, and placebo on exercise-induced heart changes. Nifedipine reduced ST-segment depression only in patients with a single stenotic coronary artery, while isosorbide dinitrate significantly reduced ST-segment depression in all groups, including those with occluded arteries and potential coronary steal. The combination of nifedipine and isosorbide dinitrate did not provide additional benefit. While nifedipine did not significantly alter heart rate, isosorbide dinitrate increased heart rate in patients with occluded arteries. These findings suggest that isosorbide dinitrate is more effective than nifedipine for reducing angina symptoms, especially in patients with more severe coronary artery disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

A randomized study comparing propranolol and diltiazem in the treatment of unstable angina.

Author: ThérouxP, TaeymansY, MorissetteD, BoschX, PelletierG B, WatersD D

Unstable angina treatment

A study of 100 patients with unstable angina found that both diltiazem and propranolol were effective in reducing chest pain episodes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

A comparison of diltiazem and atenolol in angina.

Author: WheatleyD

Reduced anginal attack rate
Reduced trinitrate requirements

A study of 78 patients with coronary heart disease compared diltiazem and atenolol for treating angina. Both drugs significantly reduced the frequency of angina attacks and the need for nitroglycerin, and improved overall well-being and exercise tolerance. However, there was no significant difference in effectiveness between the two medications. Diltiazem had very few side effects, while 3 patients had to stop taking atenolol due to side effects. These findings suggest that diltiazem is a safe and effective alternative to atenolol for treating angina.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Double-blind trial comparing labetalol with atenolol in the treatment of systemic hypertension with angina pectoris.

Author: JeeL D, OpieL H

Atenolol effective
Labetalol effective

A study of 10 patients with high blood pressure and angina found that both labetalol and atenolol were equally effective in controlling blood pressure, improving exercise tolerance, and reducing the need for nitroglycerin. However, labetalol caused a significantly higher heart rate at rest and during exercise (p<0.01) compared to atenolol. Despite the higher heart rate, labetalol did not change the heart rate-blood pressure product during exercise, suggesting potential benefits for some patients. The study concludes that both medications have advantages: labetalol due to its potential for improved exercise tolerance and atenolol for its cardioselectivity, hydrophilicity, and once-daily dosing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

The treatment of angina pectoris with the new beta-receptor blocker carteolol. Results of a controlled trial in comparison with pindolol.

Author: SimonH, SchuppanU

Angina pectoris treatment
Dyspnea

In a double-blind, randomized trial, 40 patients with angina pectoris were treated for 4 weeks with either carteolol hydrochloride or pindolol. Both drugs showed a decrease in anginal attacks and ST segment depression during exercise. While pulse rate and systolic blood pressure decreased at the end of exercise, diastolic pressure remained unchanged. Both treatments had similar effectiveness, and side effects like dyspnoea occurred in one patient per group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

A comparison of once and twice daily atenolol for angina pectoris.

Author: BoyleR M, BrayC L, NaqviN, CroxsonR S, CruickshankJ M

Angina pectoris treatment

Eleven patients with stable angina pectoris were studied with four doses of atenolol, showing improvement in exercise tolerance and duration before onset of angina. A total daily dose of 200 mg reduced maximal heart rate but did not offer additional benefits compared to lower doses. The largest increase in exercise tolerance was observed with 50 mg once daily. Atenolol was effective as an anti-anginal agent when given once daily, with no major differences between the studied doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Comparison of short-term efficacy of diltiazem and propranolol in unstable angina at rest--a randomized trial in 70 patients.

Author: Andre-FouetX, UsdinJ P, GayetC, WilnerC, ThizyJ F, VialletM, ApoilE, VernantP, PontM

Unstable angina treatment

Diltiazem was more effective than propranolol in relieving chest pain in patients with unstable angina who experienced pain only at rest.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

[Anti-angina effectiveness of the calcium antagonist nifedipine in relation to coronary involvement].

Author: SchulzW, JostS, KaltenbachM, KoberG

Reduced angina pectoris
Reduced ischemic ST-segment depression
Increased heart rate

The study found that nifedipine was effective in reducing mean ischemic ST-segment depression in patients with a single high-grade stenosis, while isosorbide dinitrate was effective in all groups. The combination of the two drugs was no more effective than isosorbide dinitrate alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

32.

Variables predictive of successful medical therapy in patients with unstable angina: selection by multivariate analysis from clinical, electrocardiographic, and angiographic evaluations.

Author: OuyangP, BrinkerJ A, MellitsE D, WeisfeldtM L, GerstenblithG

Improved work capacity

This study investigated the effectiveness of adding nifedipine to standard treatment for unstable angina. The study found that patients with more severe coronary artery blockage (70% or greater stenosis) had a higher risk of needing surgery, experiencing a heart attack, or dying. Nifedipine was found to reduce the risk of failing medical therapy by half, particularly in patients with two or more stenotic vessels or with 50% or more of their heart supplied by severely narrowed vessels. While nifedipine did not prevent heart attacks or death, it did significantly reduce the need for bypass surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

[Are calcium inhibitors useful in the treatment of effort angina pectoris].

Author: BounhoureJ P, FauvelJ M, PuelJ, SabotG, MiquelJ P

Improved work capacity

This study compared the effects of propranolol (a beta-blocker), diltiazem (a calcium channel blocker), and placebo on exercise capacity in 10 patients with stable effort angina and significant coronary artery disease. Both propranolol and diltiazem significantly improved exercise capacity compared to placebo. Propranolol was more effective than diltiazem in 6 patients, while both drugs were equally effective in 4 patients. Combining the two drugs in a small, open-label study showed even greater benefit in 3 out of 5 patients. While the small sample size limits definitive conclusions, these results suggest that diltiazem can effectively reduce angina symptoms by decreasing myocardial oxygen consumption without impairing heart muscle function, similar to the effects of beta-blockers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

34.

Medical therapy of Prinzmetal's variant angina.

Author: SchroederJ S, RosenthalS, GinsburgR, LambI

Reduced pain episodes

In a study of patients with Prinzmetal's variant angina (chest pain caused by spasms in the coronary arteries), diltiazem, a new calcium blocker, significantly reduced the number of pain episodes. 90% of patients experienced a reduction in pain episodes, with many becoming pain-free on a daily dose of 240 mg. No significant side effects were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination.

Author: LynchP, DargieH, KriklerS, KriklerD

Improved heart function
Reduced angina

Both nifedipine and propranolol, individually and in combination, significantly reduced angina symptoms compared to placebo in patients with severe exertional angina. The combination therapy proved most effective in reducing pain, glyceryl trinitrate consumption, and objectively measured ST depression on exercise mapping and ambulatory monitoring.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Antianginal effects of pentaerythritol tetranitrate.

Author: Arce-GomezE, Aspe y RosasJ, Alcocer Diaz BarreiroL, Diaz BarreiroA L

Reduced anginal attacks
Reduced nitroglycerin consumption

The study found that pentaerythritol tetranitrate (PETN) was significantly more effective than dipyridamole (DPM) in reducing the number of anginal attacks, nitroglycerin consumption, and improving exercise capacity in patients with angina pectoris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Comparative study of the effects of penbutolol and propranolol in the treatment of angina pectoris.

Author: HillisW S, TweddelA C, MurrayR G, LawrieT D

Effective angina treatment
Similar effects to propranolol

This study of 14 patients with angina found that penbutolol given once daily was as effective as propranolol given four times daily in reducing anginal episodes, glyceryl trinitrate consumption, heart rate, and blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Nifedipine and propranolol: a beneficial drug interaction.

Author: DargieH J, LynchP G, KriklerD M, HarrisL, KriklerS

Reduced angina frequency
Reduced nitroglycerin use

This study of 16 patients with chronic stable angina found that both nifedipine and propranolol were more effective than placebo in reducing angina frequency and nitroglycerin consumption. The combination of nifedipine and propranolol was even more effective than either drug alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Effects of nifedipine, acebutolol, and their association on exercise tolerance in patients with effort angina.

Author: De PontiC, De BiaseA M, PirelliS, CataldoG, SalvadéP, LanocitaM, CarùB

Increased working capacity
Reduced angina

This study of 16 patients with effort angina found that both nifedipine and acebutolol significantly increased working capacity during exercise stress testing compared to placebo. The combination of nifedipine and acebutolol was the most effective treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Short- and long-term responses to diltiazem in patients with variant angina.

Author: FeldmanR L, PepineC J, WhittleJ, ContiC R

Reduced angina frequency

This study of 12 patients with variant angina found that diltiazem was effective in reducing angina frequency both in the short-term (10 weeks) and long-term (average 16 months) trials. Responses during the short-term trial accurately predicted long-term responses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

41.

[Therapeutical comparison between atenolol and nifedipine in effort angina (author's transl)].

Author: GruppilloP, BattagliaR, MasoniC, MaistrelloI, MasoniA

Angina treatment

This study of 40 patients with stable angina pectoris found that atenolol and nifedipine were equally effective in reducing angina frequency, nitroglycerin consumption, and heart rate during exercise stress testing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

42.

Asymptomatic cardiac ischemia pilot (ACIP).

Author: ContiC R, BourassaM G, ChaitmanB R, GellerN L, KnatterudG L, PepineC J, PrattC, SopkoG

Suppressed asymptomatic cardiac ischemia

This pilot study investigated medical vs. revascularization treatments for patients with coronary artery disease (CAD) and asymptomatic ischemia. While medication effectively suppressed ischemia in 40-50% of patients, revascularization was most effective. However, both treatments significantly increase healthcare costs. The study highlights the need for larger trials to determine if treating asymptomatic ischemia reduces the risk of heart attacks and death. This will inform whether more aggressive drug therapy or complete elimination of detectable ischemia leads to better clinical outcomes compared to treating only symptoms. The answers will have major implications for patient care and healthcare costs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

[Calcium antagonists and primary prevention of coronary disease].

Author: RehnqvistN

Effective for stable angina
Platelet anti-aggregant effect
Well tolerated

This study of 809 patients with stable angina found that verapamil and metoprolol were equally effective in terms of mortality, cardiovascular events, and quality of life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

44.

Nitrates in silent ischemia.

Author: PurcellH, MulcahyD, FoxK

This review discusses the management of silent myocardial ischemia, which commonly occurs in patients with coronary artery disease. While nitrates are effective in reducing or preventing myocardial ischemia, there is no specific indication for their use in treating silent ischemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

45.

[Evaluation of amlodipine in stable effort angina. Comparison with diltiazem in terms of efficacy, tolerability and maintenance of the anti-ischemic action 24 hours after the last dose].

Author: MarchandX, TibiT, BernaudC, MorandP

Improved angina symptoms
Long-lasting effect
Drug side effects

This study compared the effectiveness of amlodipine and diltiazem in treating stable effort angina. Both drugs were effective, but amlodipine's effects lasted for at least 24 hours, providing better security and compliance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

46.

[Current indications of myocardial revascularization in unstable angina].

Author: DanchinN, AngioïM

Improved unstable angina treatment

Studies have shown that revascularization (surgery or angioplasty) is beneficial for unstable angina, especially for patients with severe blockages in multiple coronary arteries or weakened heart function. Angioplasty has become increasingly common, with promising short-term results, although complications are higher during unstable angina. Adding clot-busting drugs to angioplasty treatment may not be beneficial. However, new antithrombotic medications may reduce risks. Long-term results of angioplasty for unstable angina are similar to those for stable angina, with the likelihood of blockage returning being similar. The best treatment strategy for unstable angina is still under debate. A study found that immediate angioplasty resulted in a shorter hospital stay and fewer readmissions compared to a more conservative approach, but overall outcomes at 6 months were similar.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : French

47.

Coronary angioplasty versus medical therapy for angina: the second Randomised Intervention Treatment of Angina (RITA-2) trial. RITA-2 trial participants.

Author:

Symptomatic improvement
Procedure-related complications

Early intervention with PTCA was associated with greater symptomatic improvement, especially in patients with more severe angina. PTCA was associated with a small excess hazard due to procedure-related complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Randomized trial comparing intravenous nitroglycerin and heparin for treatment of unstable angina secondary to restenosis after coronary artery angioplasty.

Author: DoucetS, MalekianpourM, ThérouxP, BilodeauL, CôtéG, de GuiseP, DupuisJ, JoyalM, GosselinG, TanguayJ F, JuneauM, HarelF, NattelS, TardifJ C, LespéranceJ

The study discusses the treatment of unstable angina, particularly in cases of restenosis, and the potential differences in the benefits of nitroglycerin and heparin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

49.

Prognostic implications of results from exercise testing in patients with chronic stable angina pectoris treated with metoprolol or verapamil. A report from the Angina Prognosis Study In Stockholm (APSIS).

Author: ForslundL, HjemdahlP, HeldC, BjörkanderI, ErikssonS V, BrodinU, RehnqvistN

Adverse cardiovascular outcome

Patients with stable angina pectoris who experienced marked ST-segment depression during and after exercise, and had low exercise capacity were more likely to have an adverse outcome. Anginal pain alone did not predict outcome. While verapamil reduced ST-segment depression more than metoprolol, neither treatment affected prognosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Testing the effectiveness of converting patients to long-acting antianginal medications: The Quality of Life in Angina Research Trial (QUART).

Author: SpertusJ A, DewhurstT, DoughertyC M, NicholP

Angina treatment
Improved control

Converting patients with stable angina to long-acting antianginal medications resulted in substantial improvements in symptom control. Patients receiving long-acting medications had a significant improvement in anginal stability and anginal frequency compared to those whose medications were optimized. There was a trend towards better treatment satisfaction and quality of life in the long-acting group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

52.

Bypass surgery versus stenting for the treatment of multivessel disease in patients with unstable angina compared with stable angina.

Author: de FeyterP J, SerruysP W, UngerF, BeyarR, de ValkV, MiloS, SimonR, RegensburgerD, CreanP A, McGovernE, van den HeuvelP, van CauwelaertC, PennI, TyersG F O, LindeboomW

Freedom from major adverse events
Freedom from repeat revascularization

Stenting and bypass surgery showed similar outcomes in treating both unstable and stable angina in patients with multivessel disease. Stenting was associated with a lower risk of revascularization, but bypass surgery had a lower risk of major adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial.

Author: Poole-WilsonPhilip A, LubsenJacobus, KirwanBridget-Anne, van DalenFred J, WagenerGilbert, DanchinNicolas, JustHanjörg, FoxKeith A A, PocockStuart J, ClaytonTim C, MotroMichael, ParkerJohn D, BourassaMartial G, DartAnthony M, HildebrandtPer, HjalmarsonAke, KragtenJohannes A, MolhoekG Peter, OtterstadJan-Erik, Seabra-GomesRicardo, Soler-SolerJordi, WeberSimon,

Reduced need for angiogram
Reduced need for intervention
Increased peripheral revascularization

Addition of nifedipine GITS to conventional treatment of angina pectoris has no effect on major cardiovascular event-free survival. Nifedipine GITS is safe and reduces the need for coronary angiography and interventions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

Treatment of angina pectoris: associations with symptom severity.

Author: KirwanB-A, LubsenJ, Poole-WilsonP A,

Control angina symptoms

Medical treatment with anti-anginal drugs was sufficient to control symptoms for the majority of patients with chronic stable angina, with only a minority requiring invasive treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Risk score for predicting death, myocardial infarction, and stroke in patients with stable angina, based on a large randomised trial cohort of patients.

Author: ClaytonTim C, LubsenJacobus, PocockStuart J, VokóZoltán, KirwanBridget-Anne, FoxKeith A A, Poole-WilsonPhilip A

Risk score for angina

This study developed a risk score for the combination of death from all causes, myocardial infarction, and disabling stroke in patients with stable symptomatic angina.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Trimetazidine for stable angina.

Author: CiapponiA, PizarroR, HarrisonJ

Cost-effective treatment
Improved stable angina treatment
Reduced adverse effects
Stable angina

People with stable angina who don't respond to one medication are often treated with combinations of drugs, which can have side effects or be unsuitable for some patients. In low-risk groups, medication seems as effective as angioplasty for preventing heart attacks, death, or needing further procedures. Trimetazidine, another anti-anginal drug, may be better tolerated than combinations, but it's not widely used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study.

Author: MeinertzT, LehmacherW,

No clinically relevant differences
Similar effects on TET
Headache

Trapidil and isosorbide-dinitrate (ISDN) are equally effective and safe for the short-term treatment of patients with chronic stable angina pectoris. Both drugs were equally effective in improving total exercise time, but ISDN caused significantly more headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

Transmyocardial laser revascularization versus medical therapy for refractory angina.

Author: BrionesEduardo, LacalleJuan Ramon, MarinIgnacio

Improved clinical situation

Transmyocardial laser revascularization (TMLR) is being investigated as a treatment option for patients with refractory angina.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Do differences in repeat revascularization explain the antianginal benefits of bypass surgery versus percutaneous coronary intervention?: implications for future treatment comparisons.

Author: ArnoldSuzanne V, MagnusonElizabeth A, WangKaijun, SerruysPatrick W, KappeteinA Pieter, MohrFriedrich W, CohenDavid J,

CABG angina relief
PCI revascularization

Coronary artery bypass graft (CABG) is more effective in relieving angina than percutaneous coronary intervention (PCI) in patients with multivessel coronary disease. However, the mechanism of this difference is unclear and may be related to the higher rate of repeat revascularization in patients treated with PCI.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Cost-utility of ranolazine for the symptomatic treatment of patients with chronic angina pectoris in Spain.

Author: Hidalgo-VegaAlvaro, Ramos-GoñiJuan Manuel, VilloroRenata

Ranolazine
Chronic angina pectoris

Ranolazine, a medication for chest pain (angina), is used for patients whose angina is not well controlled or who cannot tolerate standard medications. The study notes that these patients often experience a significant decline in quality of life due to frequent angina episodes, which can also increase the risk of needing more invasive treatments like bypass surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Transmyocardial laser revascularization versus medical therapy for refractory angina.

Author: BrionesEduardo, LacalleJuan Ramon, Marin-LeonIgnacio, RuedaJosé-Ramón

Treat refractory angina

This review updates a previous review from 2009 on the use of transmyocardial laser revascularization (TMLR) to treat patients with refractory angina.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

WITHDRAWN: Trimetazidine for stable angina.

Author: CiapponiAgustín, PizarroRudolf, HarrisonJeff

Stable angina treatment

Stable angina (chest pain) is often treated with a combination of medications, but this can cause side effects or be inappropriate for some patients. Medical treatment appears as effective as procedures for preventing heart attacks, death, and further procedures in low-risk groups. Trimetazidine, a less common medication, has shown promise in controlling angina and may be better tolerated than combination therapy, but is not included in current guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Anti-anginal drugs-beliefs and evidence: systematic review covering 50 years of medical treatment.

Author: FerrariRoberto, PavasiniRita, CamiciPaolo G, CreaFilippo, DanchinNicolas, PintoFausto, ManolisAthanasios, MarzilliMario, RosanoGiuseppe M C, Lopez-SendonJosé, FoxKim

Improved chronic stable angina treatment

This systematic review assessed the comparative efficacy of various anti-anginal drugs for the treatment of chronic stable angina, finding that no single drug was superior to another.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Ranolazine as an additional antianginal therapy in patients with stable symptomatic coronary artery disease.

Author: SanfuentesBenjamín, BulnesJuan Francisco

Coronary artery treatment
Ranolazine

While there are effective treatments for coronary artery disease to prevent heart problems, the best way to manage symptoms, especially in those who don't respond to standard treatments, is unclear. This review explores the potential of using ranolazine as an additional medication for managing symptoms in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Spanish

65.

Anti-anginal drugs: Systematic review and clinical implications.

Author: PavasiniRita, CamiciPaolo G, CreaFilippo, DanchinNicolas, FoxKim, ManolisAthanasios J, MarzilliMario, RosanoGiuseppe M C, Lopez-SendonJosé L, PintoFausto, BallaCristina, FerrariRoberto

First and second line treatment
Stable angina treatment

Treating stable angina (chest pain) usually involves medications, divided into first-line and second-line options. However, research comparing these different types of medications is limited, and it's unclear which type is better than others.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

The Impact of Cell Therapy on Cardiovascular Outcomes in Patients With Refractory Angina.

Author: JonesDaniel A, WeeramanDeshan, ColicchiaMartina, HussainMohsin A, VeerapenDevanayegi, AndiapenMervyn, RathodKrishnaraj S, BaumbachAndreas, MathurAnthony

Angina improvement
MACE reduction
Mortality reduction

Cell-based therapies may improve cardiovascular outcomes (mortality and major adverse cardiac events) in patients with refractory angina, in addition to improving symptoms. Further definitive trials are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Acupuncture on treating angina pectoris: A systematic review.

Author: WangJi-Sheng, YuXu-Dong, DengSheng, YuanHong-Wei, LiHai-Song

Acupuncture

This study investigates the efficacy of acupuncture in treating angina pectoris, a common symptom of coronary heart disease, highlighting its potential as a complementary therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Clinical Treatment Analysis and Imaging Study of Patients with Acute Angina in Cardiovascular Medicine.

Author: LiPeng, HeLi

Clopidogrel for acute angina

This study compared the effectiveness of clopidogrel versus conventional drug treatment in patients with acute angina. The study found that clopidogrel, added to standard treatment, improved blood pressure and coronary artery stenosis, resulting in a higher total effective rate compared to the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

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