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The antinociceptive activity of intrathecally administered amiloride and its interactions with morphine and clonidine in rats.

Author: BaiXiaohui, ChenDongtai, DohiShuji, HuangWan, OuyangHandong, ZengWeian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Intrathecal administration of amiloride, morphine, or clonidine produced dose-dependent antinociception. A synergistic interaction was observed after coadministration of amiloride-morphine and amiloride-clonidine, suggesting a functional interaction among calcium channels, μ-receptors and α(2)-receptors at the spinal cord level.
Paper Details　
Original Abstract of the Article :
In this study, we aimed to evaluate the antinociceptive interaction between intrathecally administered amiloride and morphine or clonidine. Using rats chronically implanted with lumbar intrathecal catheters, we examined the ability of intrathecal amiloride, morphine, clonidine, and mixtures of amilo...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpain.2011.09.008

データ提供：米国国立医学図書館（NLM）

Unlocking the Synergistic Potential of Amiloride

Pain management is a complex desert, with many approaches seeking to alleviate suffering. This research explores the antinociceptive properties of amiloride, investigating its interactions with morphine and clonidine. The study examines the effects of intrathecally administered amiloride, morphine, clonidine, and their combinations on tail-flick latency in rats. It reveals a synergistic interaction between amiloride and both morphine and clonidine, suggesting that amiloride enhances the antinociceptive effects of these opioids.

Amiloride: A Potential Oasis for Pain Relief

This study provides a valuable insight into the synergistic potential of amiloride in pain management. The findings suggest that amiloride, in combination with morphine or clonidine, may offer a more effective approach to pain relief, potentially reducing the required doses of opioids and minimizing associated side effects.

Exploring New Pathways for Pain Management

This research encourages us to explore new avenues for pain management, leveraging the potential of synergistic interactions between different medications. It highlights the importance of understanding the complex mechanisms underlying pain perception and developing novel therapeutic strategies that address these mechanisms effectively.

Dr. Camel's Conclusion

This research reminds us that the desert of pain management is full of hidden oases. By understanding the synergistic interactions between different medications, we can create more effective and well-tolerated treatment options for those suffering from pain.

Date :
  1. Date Completed 2012-04-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22154330

DOI: Digital Object Identifier

10.1016/j.jpain.2011.09.008

Related Literature

Article Analysis
・Side Effects of amiloride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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