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[Inhibitors of androgen and estrogen biosynthesis in castration-resistant prostate cancer].

Author: GillessenS, OmlinA

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Abiraterone acetate, an androgen synthesis inhibitor, significantly improved overall survival in patients with castration-resistant prostate cancer who progressed after chemotherapy compared to prednisone alone.
Paper Details　
Original Abstract of the Article :
Advanced prostate cancer remains dependent on androgens and signaling through the androgen receptor despite castrate levels of testosterone defined as testosterone levels <1.7 nmol/l. Ketoconazole, a nonspecific inhibitor of androgen synthesis, has been tested in clinical trials and showed clinical ...See full text at original site
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引用元：
https://doi.org/10.1007/s00120-011-2737-x

データ提供：米国国立医学図書館（NLM）

Castration-Resistant Prostate Cancer: A New Weapon in the Arsenal

Prostate cancer, a disease that affects men's health, can be like a stubborn cactus in the desert – it can be difficult to eradicate completely. This study explored the use of androgen biosynthesis inhibitors, like abiraterone acetate, for the treatment of castration-resistant prostate cancer, a type of prostate cancer that doesn't respond to traditional hormone therapy. It's like finding a new weapon to combat a resilient enemy in the desert.

Abiraterone Acetate: A Promising Treatment

The researchers found that abiraterone acetate, when combined with prednisone, significantly improved overall survival in patients with castration-resistant prostate cancer. This suggests that abiraterone acetate could be a powerful tool in the fight against this challenging disease. It's like finding a new source of water in a parched desert – a lifeline that can help patients survive and thrive.

Hope for the Future

This research offers hope for patients with castration-resistant prostate cancer. It's like discovering a new oasis in the desert of cancer treatment – a beacon of hope that can guide us towards better treatments and improved outcomes. This study highlights the importance of ongoing research and development in the fight against cancer.

Dr.Camel's Conclusion

This study offers a promising new therapeutic option for patients with castration-resistant prostate cancer, demonstrating the effectiveness of abiraterone acetate in improving overall survival. It's like finding a new way to navigate the treacherous desert of prostate cancer, offering hope for a brighter future for patients and their families. This research underscores the importance of persistent research and innovation in the field of oncology.
Date :
  1. Date Completed 2012-05-24
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22258370

DOI: Digital Object Identifier

10.1007/s00120-011-2737-x

Related Literature

Article Analysis
・Side Effects of ketoconazole
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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