Toxicity and clearance of intravitreal cefotetan.

Author: AichbergerH P, AllerbergerF, MayerW, PhilippW, PümpelB, SchmidK, SteinerH J

Paper Details 
Original Abstract of the Article :
Direct intravitreal injection of antibiotics plays an important role in the management of bacterial endophthalmitis. In the present study we investigated the toxicity and clearance of intravitreally injected cefotetan in a rabbit model. No toxic ocular side effects could be detected by electroretino...See full text at original site
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引用元:
https://doi.org/10.1007/BF00927265

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Ocular Infections: A New Approach with Cefotetan

Endophthalmitis, an infection of the eye's inner lining, can be a perilous journey through the desert of vision loss. This study explores the potential of cefotetan, an antibiotic, to combat this dreaded infection. The researchers investigated the safety and efficacy of cefotetan when injected directly into the vitreous humor, the gel-like substance that fills the back of the eye. They found that cefotetan can be safely administered in high doses, achieving therapeutic concentrations for a significant duration, making it a promising candidate for treating bacterial endophthalmitis.

Cefotetan: A Potential Oasis in the Desert of Endophthalmitis

The study's findings show that cefotetan can maintain therapeutic levels in the vitreous humor for over 48 hours, effectively combating a wide range of bacteria commonly associated with endophthalmitis. This offers a potential solution for treating infections that can quickly progress and lead to vision loss. The researchers also found that cefotetan is well tolerated, even in high doses, making it a viable option for treating severe cases of endophthalmitis.

Safe and Effective Treatment for Endophthalmitis

This study suggests that cefotetan could offer a safer and more effective treatment option for endophthalmitis, potentially reducing the need for multiple injections and improving patient outcomes. The research opens new possibilities for combating this serious eye infection, offering a beacon of hope for patients facing this debilitating condition.

Dr.Camel's Conclusion

This study is a testament to the ongoing quest for new treatments and therapies. Just as a camel navigates the desert in search of water, we must continue to explore new pathways to combat eye infections. Cefotetan, with its promising safety and efficacy, offers a potential oasis in the desert of endophthalmitis, providing hope for a brighter future for patients struggling with this debilitating condition.

Date :
  1. Date Completed 1990-12-19
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

2227495

DOI: Digital Object Identifier

10.1007/BF00927265

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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