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Daunorubicin-TiO2 nanocomposites as a "smart" pH-responsive drug delivery system.

Author: ChenBaoan, WangCailian, WangXuemei, ZhangHaijun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Daunorubicin (DNR) is an anticancer drug with a broad spectrum of activity but limited clinical application due to its serious side effects. This study investigated the use of a novel 'smart' pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO(2)) nanoparticles to enhance the chemotherapeutic efficiency of DNR.
Paper Details　
Original Abstract of the Article :
Daunorubicin (DNR) has a broad spectrum of anticancer activity, but is limited in clinical application due to its serious side effects. The aim of this study was to explore a novel "smart" pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO(2)) nanoparticles for its potential in ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263415/

データ提供：米国国立医学図書館（NLM）

Smart Drug Delivery for Cancer Therapy

Daunorubicin (DNR), a potent anticancer drug, is often limited in clinical use due to its severe side effects. This research explores a novel pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO2) nanoparticles to improve the efficacy and reduce the side effects of DNR. The study investigates the ability of DNR-TiO2 nanocomposites to deliver DNR selectively to tumor cells, where the pH environment is more acidic than in normal tissues.

Harnessing the Power of pH-Responsive Delivery

The study found that DNR-TiO2 nanocomposites released DNR more rapidly at acidic pH levels, demonstrating the potential for targeted drug delivery to tumor cells. This smart delivery approach could enhance the therapeutic efficacy of DNR while minimizing side effects. The study also found that DNR-TiO2 nanocomposites significantly enhanced the anticancer activity of DNR, suggesting a promising avenue for improving cancer treatment outcomes.

Precision in Cancer Treatment

Advances in drug delivery are transforming the way we treat cancer. This research showcases the potential of pH-responsive DDS to deliver drugs selectively to tumor cells, minimizing damage to healthy tissues. This approach could lead to more effective and less toxic therapies, improving the quality of life for cancer patients.

Dr.Camel's Conclusion

This research highlights the innovative approaches being developed to combat cancer. Like a camel seeking a hidden oasis in the vast desert, researchers are diligently searching for new ways to deliver cancer therapies with precision and effectiveness. The use of pH-responsive DDS represents a promising step forward in the fight against this debilitating disease.

Date :
  1. Date Completed 2012-08-06
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22275838

DOI: Digital Object Identifier

PMC3263415

Related Literature

Article Analysis
・Side Effects of daunorubicin
SNS
PICO Info
in preparation
Languages

English

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