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Hypericin for visualization of high grade gliomas: first clinical experience.

Author: BornemannA, DanielsR, DietzK, FeiglG C, MayerD, NoellS, RaminaK, RitzR, SchmidtV, StraussW S L, TatagibaM

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hypericin, a component of St. Johns Wort, effectively visualizes malignant gliomas. In 5 patients with recurrent malignant glioma, Hypericin was given intravenously 6 hours before surgery. Tumor tissue was clearly distinguishable from normal brain tissue under fluorescence mode. Hypericin was well tolerated with no observed side effects.
Paper Details　
Original Abstract of the Article :
AIMS: We aimed to demonstrate that Hypericin, a component of St. Johns Wort, selectively visualizes malignant gliomas. Hypericin is known as one of the most powerful photosensitizers in nature with excellent fluorescent properties. METHODS: In five patients with a recurrence of a malignant glioma a...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejso.2011.12.021

データ提供：米国国立医学図書館（NLM）

Hypericin: A New Light for Brain Tumor Detection

In the vast expanse of medical research, the search for effective treatments for brain tumors is a journey akin to a caravan crossing a treacherous desert. This study explores the potential of Hypericin, a natural photosensitizer, as a beacon of hope for identifying malignant gliomas. Hypericin, with its remarkable fluorescent properties, acts like a luminous guidepost in the shadowy realm of brain tumor detection.

Illuminating Brain Tumors

The study found that Hypericin, when administered intravenously, effectively highlighted malignant glioma tissue under a special fluorescent filter. The contrast between the red fluorescence of the tumor and the blue fluorescence of normal brain tissue was striking, much like the contrast between a shimmering mirage and the parched desert landscape. Importantly, the study demonstrated the safety and efficacy of Hypericin in its water-soluble form. This discovery, like a wellspring of water in the arid desert, holds the promise of improving brain tumor surgery and potentially paving the way for novel therapeutic approaches.

A New Era of Brain Tumor Treatment

This research, like a star guiding a caravan across the desert, opens up exciting new avenues for the diagnosis and treatment of malignant gliomas. The combination of Hypericin's fluorescent properties with photodynamic therapy, much like the harmonious interplay of light and shadow, offers a promising strategy for combating this challenging disease. This study, like a beacon of hope in the vast desert of brain tumor research, signifies a potential breakthrough in the fight against this devastating illness.

Dr.Camel's Conclusion

This research shines a new light on brain tumor detection, providing a beacon of hope for those battling this challenging disease. Hypericin, with its unique fluorescent properties, acts like a celestial guide, illuminating the path toward more precise surgical intervention and potentially innovative therapeutic strategies. This study is a testament to the power of nature and scientific ingenuity in the face of medical challenges.
Date :
  1. Date Completed 2012-04-26
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

22284346

DOI: Digital Object Identifier

10.1016/j.ejso.2011.12.021

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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