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Linezolid for the treatment of complicated drug-resistant tuberculosis: a systematic review and meta-analysis.

Author: CoxH, FordN

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Treatment for drug-resistant tuberculosis (DR-TB) is not ideal, with worse outcomes than for non-resistant TB, especially in people who have already been treated with second-line drugs or who have highly drug-resistant (XDR-) TB. While linezolid is not recommended for routine DR-TB treatment due to a lack of evidence, it may be considered for patients with complex DR-TB who cannot be treated with standard regimens.
Paper Details　
Original Abstract of the Article :
Current treatment for drug-resistant tuberculosis (DR-TB) is inadequate, and outcomes are significantly poorer than for drug-susceptible TB, particularly for patients previously treated with second-line drugs, treatment failures or extensively drug-resistant (XDR-) TB patients (complicated DR-TB). L...See full text at original site
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引用元：
https://doi.org/10.5588/ijtld.11.0451

データ提供：米国国立医学図書館（NLM）

Linezolid for Drug-Resistant Tuberculosis: A Potential Weapon in the Desert

This systematic review and meta-analysis evaluates the effectiveness of linezolid, an antibiotic, in treating drug-resistant tuberculosis (DR-TB), a serious and challenging infection. DR-TB strains are resistant to standard antibiotics, requiring more complex and often less effective treatment regimens. While linezolid is not currently recommended for routine DR-TB treatment, the study explores its potential as a treatment option for patients with complicated DR-TB, who struggle with finding effective treatment options. The findings suggest that linezolid might offer a valuable alternative for these patients, potentially improving their outcomes.

Fighting Drug-Resistant Tuberculosis: A Desert of Challenges

The study's findings offer a glimmer of hope in the desert of DR-TB treatment. Linezolid, an antibiotic not typically used for DR-TB, might offer a valuable treatment option for patients with complicated DR-TB, who struggle with finding effective treatment options. This research is a stepping stone in the ongoing journey to develop more effective treatments for DR-TB.

Understanding Drug-Resistant Tuberculosis: A Journey Through the Desert

This systematic review and meta-analysis highlights the challenges of treating DR-TB, a serious and challenging infection. The study underscores the need for continued research and development of new and effective treatments for DR-TB. It serves as a reminder that the desert of DR-TB treatment is vast and complex, but that persistent exploration can lead to new solutions for patients struggling with this condition.

Dr.Camel's Conclusion

This systematic review and meta-analysis explores the potential of linezolid for treating complicated drug-resistant tuberculosis. The findings suggest that linezolid might offer a valuable alternative treatment option for patients with limited treatment options. The study underscores the need for continued research and development of new and effective treatments for drug-resistant tuberculosis.
Date :
  1. Date Completed 2012-09-26
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

22325685

DOI: Digital Object Identifier

10.5588/ijtld.11.0451

SNS
PICO Info
in preparation
Languages

English

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