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Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei.

Author: AdamsMichael, BrunReto, HamburgerMatthias, KaiserMarcel, ZimmermannStefanie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study identified cynaropicrin from Centaurea salmantica L. as a potent inhibitor of Trypanosoma brucei rhodesiense, demonstrating its in vitro and in vivo efficacy against the parasite.
Paper Details　
Original Abstract of the Article :
A screen of 1800 plant and fungal extracts with subsequent HPLC-based activity profiling was done to identify new antiprotozoal leads from nature. This led to the identification of cynaropicrin (1) from the herb CENTAUREA SALMANTICA L. (Asteraceae) as a potent IN VITRO inhibitor of TRYPANOSOMA BR...See full text at original site
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引用元：
https://doi.org/10.1055/s-0031-1298241

データ提供：米国国立医学図書館（NLM）

A Botanical Oasis: Cynaropicrin and its Anti-Trypanosomal Potential

Imagine a vast desert teeming with life, like the intricate world of [parasitology]. This research, like a dedicated botanist, explores the potential of [cynaropicrin], a natural product extracted from the [CENTAUREA SALMANTICA L.] plant, as a potent weapon against the deadly parasite [TRYPANOSOMA BRUCEI]. The authors, like skilled explorers, uncover a new lead in the fight against [African trypanosomiasis], a disease that plagues millions worldwide.

Their findings, like a shimmering oasis in the desert, demonstrate the powerful in vitro and in vivo activity of cynaropicrin against [TRYPANOSOMA BRUCEI RHODESIENSE] and [TRYPANOSOMA BRUCEI GAMBIENSE]. This discovery presents a promising new avenue for developing novel anti-parasitic drugs and offers hope for those affected by this devastating disease.

A New Weapon in the Fight Against Trypanosomiasis: Harnessing the Power of Cynaropicrin

The study's findings highlight the potential of [cynaropicrin] as a valuable tool in the fight against [trypanosomiasis]. The authors emphasize the need for further research to optimize the delivery and efficacy of this natural product, paving the way for new therapeutic strategies.

A Beacon of Hope: Seeking Natural Solutions to Parasitic Infections

This research underscores the importance of exploring the vast world of [natural products] in our search for new treatments for [parasitic infections]. The discovery of cynaropicrin's anti-trypanosomal activity offers hope for a more sustainable and effective approach to combating this global health threat.

Dr. Camel's Conclusion

This study reminds us that the desert of [parasitology] holds a wealth of potential for new discoveries. The exploration of natural products, like cynaropicrin, offers a promising avenue for developing innovative and sustainable solutions to combat the devastating effects of parasitic infections.

Date :
  1. Date Completed 2012-11-28
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

22331812

DOI: Digital Object Identifier

10.1055/s-0031-1298241

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Languages

English

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