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Solubilization of beclomethasone dipropionate in sterically stabilized phospholipid nanomicelles (SSMs): physicochemical and in vitro evaluations.

Author: AbdulameerShaymaa Abdalwahed, DarwisYusrida, PehKok Khiang, SahibMohanad Naji, TanYvonne Tze Fung

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This article discusses the advantages of pulmonary drug delivery for local treatment of lung disorders such as asthma and chronic obstructive pulmonary disease. Pulmonary delivery can improve local drug concentrations, enhance receptor occupancy, and reduce overall drug dose, minimizing side effects. The authors highlight the need for improved jet nebulizer technology to facilitate delivery of hydrophobic drugs.
Paper Details　
Original Abstract of the Article :
The local treatment of lung disorders such as asthma and chronic obstructive pulmonary disease via pulmonary drug delivery offers many advantages over oral or intravenous routes of administration. This is because direct deposition of a drug at the diseased site increases local drug concentrations, w...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287410/

データ提供：米国国立医学図書館（NLM）

Delivering Lung Medications: A Targeted Approach

Local treatment of lung disorders, such as asthma and chronic obstructive pulmonary disease (COPD), offers significant advantages over systemic administration. Direct delivery of medication to the affected area increases local drug concentrations, maximizing therapeutic effects and minimizing side effects. This research explores the use of sterically stabilized phospholipid nanomicelles (SSMs) for the delivery of beclomethasone dipropionate, a commonly used inhaled corticosteroid.

The authors investigated the physicochemical properties and in vitro efficacy of beclomethasone dipropionate formulated in SSMs. They found that SSMs effectively solubilized the drug, enhancing its delivery to the lungs and potentially improving treatment outcomes.

Nanotechnology: A New Frontier for Drug Delivery

This research highlights the potential of nanotechnology to improve drug delivery and enhance therapeutic efficacy. The use of SSMs for beclomethasone dipropionate offers a promising approach to enhance lung drug delivery, potentially leading to better treatment outcomes for patients with lung disorders.

Breathing Easier: A New Era of Lung Medications

The research paves the way for a new generation of lung medications that are more effective and have fewer side effects. The use of nanotechnology to improve drug delivery is a groundbreaking development, potentially leading to better treatment outcomes for patients with lung disorders, helping them breathe easier and live healthier lives.

Dr.Camel's Conclusion

Just as a camel navigates the vast desert, delivering medications to the lungs requires a precise and effective approach. This research explores the use of nanotechnology, a groundbreaking innovation that could significantly improve drug delivery and treatment outcomes for patients with lung disorders. It's a step toward a future where breathing easier is within reach.

Date :
  1. Date Completed 2012-05-25
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22393583

DOI: Digital Object Identifier

PMC3287410

Related Literature

Article Analysis
・Side Effects of beclomethasone oral inhalation
SNS
PICO Info
in preparation
Languages

English

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