Pharmacokinetics and repolarization effects of intravenous and transdermal granisetron.

Author: DonachiePeter, HowellJulian, MasonJay W, MoonThomas E, O'MahonyBridget, SelnessDaniel S

Paper Details 
Original Abstract of the Article :
The need for greater clarity about the effects of 5-HT(3) receptor antagonists on cardiac repolarization is apparent in the changing product labeling across this therapeutic class. This study assessed the repolarization effects of granisetron, a 5-HT(3) receptor antagonist antiemetic, administered i...See full text at original site
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引用元:
https://doi.org/10.1158/1078-0432.CCR-11-2785

データ提供:米国国立医学図書館(NLM)

Investigating the Cardiac Effects of Granisetron: A Journey into the Heart of Antiemetic Therapy

Granisetron, a medication used to prevent nausea and vomiting, is often administered to patients undergoing chemotherapy or surgery. This study, like a careful cartographer mapping the intricacies of a desert ecosystem, investigates the cardiac effects of granisetron when administered intravenously or through a transdermal system.

Navigating the Cardiac Landscape

The study assessed the repolarization effects of granisetron, a crucial aspect of heart function. This is like examining the delicate balance of sand and water that creates a stable dune system. The researchers sought to understand how granisetron affects this vital process, ensuring its safe use in patients.

A Deeper Understanding of Antiemetic Therapy

This research provides valuable insights into the cardiac safety profile of granisetron. It is like gaining a deeper understanding of the delicate ecosystem within a desert, allowing us to navigate this complex landscape with greater knowledge and care.

Dr.Camel's Conclusion

This study, like a cautious camel traversing a sandy terrain, examines the cardiac effects of granisetron, providing valuable information for clinicians and patients alike. By carefully assessing the potential risks and benefits of this medication, we can ensure its safe and effective use.

Date :
  1. Date Completed 2012-11-05
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

22452942

DOI: Digital Object Identifier

10.1158/1078-0432.CCR-11-2785

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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