Paper Details

  1. Home
  2. Paper Details

Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial.

Author: BirnHenrik, ErlandsenErland J, JensenDanny, LangdahlBente L, LaursenAlex L, NielsenUlla S, RasmussenThomas A, TolstrupMartin, ØstergaardLars

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Switching to TDF/FTC-based therapy led to decreases in BMD and increases in bone turnover markers compared with ABC/3TC-based treatment. No major difference in renal function was observed.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Our objective was to compare the bone and renal effects among HIV-infected patients randomized to abacavir or tenofovir-based combination anti-retroviral therapy. METHODS: In an open-label randomized trial, HIV-infected patients were randomized to switch from zidovudine/lamivudine (AZ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315554/

データ提供：米国国立医学図書館（NLM）

Exploring the Impact of HIV Treatment on Bone and Kidney Health

The treatment of HIV has made tremendous strides, but the long-term effects of antiretroviral therapy are still being explored. This study focuses on the impact of two commonly used antiretroviral drugs, abacavir and tenofovir, on bone and kidney health in HIV-infected patients. Researchers conducted a randomized trial to compare the effects of switching to abacavir-based therapy versus tenofovir-based therapy on bone density, bone turnover markers, and renal function.

The Shifting Sands of HIV Treatment: A Closer Look at Side Effects

The study's findings highlight a significant difference in the impact of the two drugs on bone health. Patients who switched to tenofovir-based therapy experienced a decrease in bone density, particularly in the hip and lumbar spine, compared to those who switched to abacavir-based therapy. This finding underscores the importance of monitoring bone health in patients receiving tenofovir-based treatment. However, while tenofovir appeared to have a more pronounced impact on bone, both drugs were found to be relatively safe for kidney function.

Navigating the Desert of Antiretroviral Therapy: A Balancing Act

This study serves as a reminder that navigating the desert of HIV treatment involves a delicate balancing act. While antiretroviral therapy has revolutionized the management of HIV, it is essential to be aware of the potential long-term effects of these drugs. This research highlights the importance of individualized care and ongoing monitoring to ensure the best possible health outcomes for patients.

Dr.Camel's Conclusion

This research underscores the need for ongoing vigilance in monitoring the long-term effects of antiretroviral therapy. It reminds us that even in the face of significant advances in treatment, we must always strive to understand the complexities of the desert we are navigating. The findings of this study offer valuable insights to guide clinicians in providing personalized care for their patients.

Date :
  1. Date Completed 2012-08-28
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

22479327

DOI: Digital Object Identifier

PMC3315554

Related Literature

Article Analysis
・Effects of lamivudine and zidovudine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.