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New treatment strategies in idiopathic nephrotic syndrome.

Author: AounB, UlinskiT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Idiopathic nephrotic syndrome (INS) is a kidney disease characterized by massive proteinuria. Most patients respond to steroids, but some become steroid dependent. This study reviewed the challenges of treating steroid-dependent and steroid-resistant forms of INS. Cyclosporine A (CyA) and cyclophosphamide (CyP) have been used to treat these cases, but specific toxicity limits their use. Mycophenolate mofetil (MMF) and rituximab (RTX) have emerged as new treatment options.
Paper Details　
Original Abstract of the Article :
Idiopathic nephrotic syndrome (INS) is probably due to a plasma factor of immunologic origin. This circulating factor probably interacts with the glomerular filtration barrier and is responsible for massive proteinuria. Most patients respond to steroids. However, a considerable proportion of childre...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22495188

データ提供：米国国立医学図書館（NLM）

Idiopathic Nephrotic Syndrome: Navigating the Desert of Kidney Disease

Idiopathic nephrotic syndrome (INS), a kidney disorder characterized by proteinuria, is often a challenging condition to manage. This study explores new treatment strategies for INS, particularly focusing on steroid-dependent and steroid-resistant forms of the disease. The authors discuss the use of various immunosuppressive medications, including cyclosporine A, cyclophosphamide, mycophenolate mofetil, and rituximab, in treating INS. They highlight the potential benefits and drawbacks of each treatment option, emphasizing the importance of individualizing treatment based on patient factors and the severity of the disease.

The study emphasizes the need for careful monitoring and management of patients with INS, particularly those who are steroid-dependent or steroid-resistant. The authors discuss the importance of balancing the risks and benefits of immunosuppressive therapy, considering the potential for side effects and long-term complications.

Finding a Path in the Desert of Kidney Disease

This study provides a valuable overview of current treatment strategies for INS, offering guidance for navigating the complexities of this condition. The authors emphasize the importance of individualizing treatment based on patient factors and the need for careful monitoring and management to minimize the risk of side effects and long-term complications.

A Desert Oasis of Kidney Health

Just as a camel adapts to the harsh conditions of a desert environment, individuals with INS must navigate the challenges of living with kidney disease. This study provides valuable insights into the latest treatment options, offering a potential oasis in the desert of kidney disease.

Dr. Camel's Conclusion

This study provides a comprehensive overview of current treatment strategies for idiopathic nephrotic syndrome, highlighting the importance of a tailored approach to management, balancing the risks and benefits of treatment, and monitoring for potential complications.

Date :
  1. Date Completed 2012-07-24
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

22495188

DOI: Digital Object Identifier

R15123771

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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