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Topical 5% tranexamic acid for the treatment of melasma in Asians: a double-blind randomized controlled clinical trial.

Author: Kanechorn Na AyuthayaPinyapat, ManosroiAranya, NakakesArtit, NiumphraditNucha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This double-blind, randomized, prospective study evaluated the efficacy of topical 5% tranexamic acid (TA) versus vehicle for the treatment of melasma. While 78.2% of patients showed a decrease in the melanin index after 12 weeks, the lightening of pigmentation induced by TA was not significantly different from its vehicle. However, topical TA was associated with a significant increase in erythema.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Topical tranexamic acid has been claimed to lighten melasma without serious adverse effects. However, controlled studies assessing the efficacy and safety of topical tranexamic acid (TA) for the treatment of melasma is limited. OBJECTIVE: To assess in a double blind, randomized, prospec...See full text at original site
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引用元：
https://doi.org/10.3109/14764172.2012.685478

データ提供：米国国立医学図書館（NLM）

Topical Tranexamic Acid: A New Oasis for Melasma

[Melasma] is a common skin condition that can affect self-esteem and confidence. This study, like a camel traversing a vast desert landscape, investigates the effectiveness of [topical tranexamic acid (TA)] for treating melasma. The researchers found that topical TA led to a decrease in pigmentation in most patients, but the effect was not significantly different from the vehicle. This suggests that topical TA might be effective for treating melasma, but further research is needed to confirm its efficacy and optimize its use.

A Promising Approach: Topical Tranexamic Acid for Melasma

The study's findings suggest that topical TA holds potential for treating melasma, offering a glimmer of hope for individuals seeking to improve their skin's appearance. However, the lack of significant difference compared to the vehicle suggests that further research is needed to determine the optimal use of topical TA for treating melasma.

Navigating the Desert of Skin Concerns: A Reminder

The desert of skin concerns can be daunting, but there are oases of hope. If you're concerned about melasma or other skin conditions, consult a dermatologist to discuss available treatment options. Remember, taking care of your skin is important for both your health and self-esteem.

Dr.Camel's Conclusion

This study, like a gentle breeze across the desert, provides valuable insights into the potential of topical TA for treating melasma. While the results are promising, further research is needed to fully understand its efficacy and optimize its use. As we continue to explore the vast desert of skin care research, we may find new ways to help individuals achieve their desired skin health goals.

Date :
  1. Date Completed 2012-10-29
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

22506692

DOI: Digital Object Identifier

10.3109/14764172.2012.685478

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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