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Pharmacodynamic effects of prasugrel dosing regimens in patients on maintenance prasugrel therapy: results of a prospective randomized study.

Author: AngiolilloDominick J, BassTheodore A, BoxLyndon C, CharltonRonald K, DesaiBhaloo, FerreiroJosé Luis, GuzmanLuis A, KodaliMurali, SeecheranNaveen, Tello-MontoliuAntonio, TomaselloSalvatore D, UenoMasafumi, ZenniMartin M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A 60 mg dose of prasugrel was associated with faster and higher platelet inhibition compared with lower doses (10 mg and 30 mg) in patients on maintenance prasugrel therapy.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The purpose of this study is to assess the pharmacodynamic effects of different prasugrel dosing regimens in patients on maintenance prasugrel therapy. BACKGROUND: There are a growing number of patients on chronic prasugrel therapy regimens, leading to questions about the dosing regimen...See full text at original site
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引用元：
https://doi.org/10.1016/j.jacc.2011.12.039

データ提供：米国国立医学図書館（NLM）

Pharmacodynamic Effects of Prasugrel Dosing Regimens

This study investigates the pharmacodynamic effects of different prasugrel dosing regimens in patients on maintenance prasugrel therapy. Prasugrel is a medication used to prevent blood clots in patients with coronary artery disease. The study used a prospective randomized design, randomly assigning 64 patients to receive either 10 mg, 30 mg, or 60 mg of prasugrel. The study found that a 60 mg dose of prasugrel resulted in faster and higher platelet inhibition compared to lower doses.

Optimizing Prasugrel Dosing for Effective Platelet Inhibition

This research provides valuable insights into the pharmacodynamics of prasugrel, a medication used to prevent blood clots in patients with coronary artery disease. The study demonstrates that a 60 mg dose of prasugrel is associated with faster and higher platelet inhibition compared to lower doses.

Tailoring Prasugrel Dosing for Individualized Patient Care

The study’s findings highlight the importance of tailoring prasugrel dosing to individual patient needs. This information is crucial for clinicians seeking to optimize the effectiveness of prasugrel therapy and minimize the risk of blood clots in patients with coronary artery disease.

Dr.Camel's Conclusion

This study provides valuable information about the pharmacodynamic effects of prasugrel dosing regimens. The findings underscore the importance of individualized care in optimizing prasugrel therapy and achieving the best possible outcomes for patients with coronary artery disease. It’s a testament to the fact that even in the vast desert of medical treatments, finding the right dosage for each patient is essential.

Date :
  1. Date Completed 2012-06-26
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

22554598

DOI: Digital Object Identifier

10.1016/j.jacc.2011.12.039

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Languages

English

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