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Assessing the risk of subsequent tonic-clonic seizures in patients with a history of simple or complex partial seizures.

Author: ChadwickDavid W, HuttonJane, MarsonAnthony G, RogersJennifer K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Patients presenting with only partial seizures are at low risk of subsequent tonic-clonic seizures. The effects of antiepileptic drugs are greater for tonic-clonic seizures than for partial seizures.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Patients who present with only simple or complex partial seizures have a poorly documented prognosis. Treatment may be advocated to prevent future secondary generalised seizures, reduce the frequency of further simple or complex partial seizures or a combination of both. METHODS: A full...See full text at original site
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引用元：
https://doi.org/10.1136/jnnp-2011-300917

データ提供：米国国立医学図書館（NLM）

Predicting Seizures: A Prognostic Journey

Epilepsy, a neurological disorder characterized by recurrent seizures, can be a challenging condition to manage. This research explores the risk of subsequent tonic-clonic seizures, a type of generalized seizure, in patients with a history of only simple or complex partial seizures, which are seizures affecting only part of the brain. The study utilizes data from a large multicenter study of early epilepsy and single seizures (MESS) to assess the prognostic factors associated with the development of tonic-clonic seizures.

Low Risk of Tonic-Clonic Seizures

The study demonstrates that patients with a history of only partial seizures have a relatively low risk of experiencing subsequent tonic-clonic seizures, particularly within the time frame relevant for therapeutic decision-making. The presence of an abnormal electroencephalogram (EEG) at baseline, however, was found to increase the risk of tonic-clonic seizures.

Personalized Epilepsy Management

This research highlights the importance of personalized epilepsy management, considering individual patient factors and risk profiles. The study emphasizes the need for careful monitoring and tailored treatment strategies to prevent the development of more severe seizure types.

Dr.Camel's Conclusion

Just as a camel navigates the unpredictable terrain of the desert, researchers are constantly exploring the complex landscape of epilepsy. This study provides valuable insights into the risk of tonic-clonic seizures in patients with a history of partial seizures, highlighting the importance of personalized treatment approaches and careful monitoring to ensure the best possible outcomes for patients.

Date :
  1. Date Completed 2012-09-21
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

22696580

DOI: Digital Object Identifier

10.1136/jnnp-2011-300917

Related Literature

Article Analysis
・Effective treatment of seizures
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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