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Effectiveness of Vi capsular polysaccharide typhoid vaccine among children: a cluster randomized trial in Karachi, Pakistan.

Author: , AcostaCamilo J, BhuttaZulfiqar A, ClemensJohn D, HabibMohammad Atif, KhanM Imran, NizamiS Qamaruddin, OchiaiR Leon, SahitoShah Muhammad, SoofiSajid Bashir

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The ViCPS vaccine did not show statistically significant protection against typhoid fever in children aged 2-5 years. However, the vaccine showed significant total protection in children aged 5-16 years, suggesting that vaccinating school-aged children in urban, typhoid endemic areas may protect them against typhoid fever.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Typhoid fever is endemic in Karachi, with an incidence among children ranging from 170 to 450 per 100,000 child-years. Vaccination strategies are important for prevention, and the Vi capsular polysaccharide (ViCPS) vaccine has been shown to be effective in reducing the burden of typhoid ...See full text at original site
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引用元：
https://doi.org/10.1016/j.vaccine.2012.06.015

データ提供：米国国立医学図書館（NLM）

Vi Capsular Polysaccharide Typhoid Vaccine: Evaluating its Effectiveness in Children

Typhoid fever, a serious bacterial infection, remains a major public health concern, particularly in developing countries. This study investigates the effectiveness of the Vi capsular polysaccharide typhoid vaccine in preventing typhoid fever in children living in Karachi, Pakistan. The researchers conduct a cluster randomized trial, comparing the incidence of typhoid fever in children who received the ViCPS vaccine to those who received a control vaccine.

Vi Capsular Polysaccharide Typhoid Vaccine: Mixed Results in Children

The study reveals that the ViCPS vaccine did not provide statistically significant protection against typhoid fever in all children in the study population. However, the study also highlights that the vaccine showed significant protection for children aged 5-16 years, suggesting that it may be more effective in older children.

Vi Capsular Polysaccharide Typhoid Vaccine: Tailoring Vaccination Strategies

This research provides valuable insights into the effectiveness of the ViCPS vaccine in different age groups. The study underscores the importance of tailoring vaccination strategies based on age and other factors, ensuring that the most effective vaccines are used to protect children from typhoid fever.

Dr.Camel's Conclusion

Like a camel traversing a vast and challenging desert, this research explores the effectiveness of the ViCPS vaccine in protecting children from typhoid fever. While the study reveals mixed results, it highlights the importance of considering age-specific vaccination strategies to ensure maximum protection against this potentially deadly disease.

Date :
  1. Date Completed 2012-12-21
  2. Date Revised 2012-07-20
Further Info :

Pubmed ID

22721899

DOI: Digital Object Identifier

10.1016/j.vaccine.2012.06.015

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・Effects of typhoid vaccine
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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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