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Effect of combination treatment on lung volumes and exercise endurance time in COPD.

Author: KestenSteven, MagnussenHelgo, MaltaisFrançois, MetzdorfNorbert, PaggiaroPierluigi, SchmidtHendrik

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Two bronchodilators (tiotropium and salmeterol) decreased hyperinflation significantly more than one bronchodilator plus inhaled corticosteroid (salmeterol and fluticasone) in patients with chronic obstructive pulmonary disease (COPD). However, this difference was not reflected in exercise endurance time.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Data comparing two bronchodilators vs. one bronchodilator plus inhaled corticosteroid (ICS) on hyperinflation and exercise endurance in chronic obstructive pulmonary disease (COPD) are scarce, though these therapeutic strategies are widely used in clinical practice. METHODS: We performe...See full text at original site
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引用元：
https://doi.org/10.1016/j.rmed.2012.05.011

データ提供：米国国立医学図書館（NLM）

Bronchodilators and Inhaled Corticosteroids: A Balancing Act for COPD

The quest to improve the lives of patients with [chronic obstructive pulmonary disease (COPD)] is a constant challenge. This study investigates the relative effectiveness of two therapeutic approaches for COPD: combining two bronchodilators versus using one bronchodilator along with an inhaled corticosteroid (ICS).

The researchers recruited [309 COPD patients] and randomly assigned them to receive either tiotropium and salmeterol (T+S) or salmeterol and fluticasone (S+F) in a crossover design. They measured [lung volumes] and [exercise endurance] over a period of eight weeks. The study found that T+S led to a significantly greater reduction in hyperinflation compared to S+F. However, this difference didn't translate into a significant improvement in exercise endurance time.

Navigating the COPD Treatment Landscape: A Journey Through the Desert of Airflow

This study provides valuable insights into the complexities of COPD treatment. It suggests that while combining two bronchodilators can effectively reduce hyperinflation, its impact on exercise capacity may be more limited. This finding underscores the need for personalized treatment approaches that consider the individual patient's needs and goals.

Finding the Right Path for COPD Treatment

The desert of COPD is a challenging landscape. It's essential to find the right path to manage airflow limitations and improve quality of life. This study sheds light on the potential benefits and limitations of various therapeutic approaches, emphasizing the importance of individualized care.

Dr.Camel's Conclusion

The study highlights the importance of finding the right therapeutic balance in COPD. It's like choosing the right caravan route through the desert. Some routes may lead to oases of relief, while others may lead to dead ends. Individualized care and careful monitoring are essential in managing this complex disease.

Date :
  1. Date Completed 2012-12-31
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

22749044

DOI: Digital Object Identifier

10.1016/j.rmed.2012.05.011

SNS
PICO Info
in preparation
Languages

English

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