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Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability.

Author: BurnettArthur L, DayWesley W, DiDonatoKaren, HellerWarren H, KikkawaKohei, KoteraJun, OmoriKenji, PetersonCraig A, WangRun, YeeShiyin

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Avanafil, a PDE5 inhibitor for erectile dysfunction, exhibits strong selectivity toward PDE5, potentially reducing side effects associated with inhibiting other PDE isozymes.
Paper Details　
Original Abstract of the Article :
Phosphodiesterase type 5 (PDE5) inhibitors are indicated for the treatment of erectile dysfunction (ED); however, they can also inhibit other PDE isozymes, affecting their target tissues (e.g., PDE1: heart; PDE6: retina; and PDE11: skeletal muscle), which in some cases can cause unwanted side effect...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22759639

データ提供：米国国立医学図書館（NLM）

Avanafil: A New Player in the Game of Erectile Dysfunction

Phosphodiesterase type 5 (PDE5) inhibitors have revolutionized the treatment of erectile dysfunction (ED). This research focuses on avanafil, a new PDE5 inhibitor, and its remarkable selectivity for PDE5 over other isozymes. The authors highlight the potential of avanafil to provide targeted treatment with fewer side effects compared to other PDE5 inhibitors. This study offers a promising glimpse into the future of ED treatment, emphasizing the importance of precise targeting for enhanced efficacy and safety.

Selectivity: A Key to Navigating the Sands of ED Treatment

This research underscores the importance of selectivity in drug development. Just as a camel navigating a desert must carefully choose its path to avoid treacherous terrain, researchers are increasingly focused on developing drugs that target specific pathways with minimal off-target effects. This study highlights the potential of avanafil to provide a more tailored approach to ED treatment, minimizing the risk of unwanted side effects.

The Evolution of ED Treatment

This research showcases the continuous evolution of ED treatment. As we delve deeper into the mechanisms of ED and explore new drug candidates, we are witnessing a shift towards more targeted therapies that offer greater precision and fewer unwanted effects. This study serves as a reminder of the dynamic nature of medical research and its potential to improve patient care.

Dr. Camel's Conclusion

This research offers a promising glimpse into the future of ED treatment. The remarkable selectivity of avanafil for PDE5 suggests a new era of targeted therapy, minimizing unwanted side effects and maximizing patient well-being. As we continue to explore the vast landscape of medical innovation, research like this guides us toward more effective and personalized approaches to patient care.

Date :
  1. Date Completed 2014-01-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

22759639

DOI: Digital Object Identifier

S1743-6095(15)34067-4

Related Literature

Article Analysis
・Side Effects of avanafil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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