Side Effects of avanafil: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Main Research Findings

Avanafil is a new type of PDE5 inhibitor used to treat erectile dysfunction, and it is characterized by a faster onset and shorter duration of action compared to other PDE5 inhibitors. 9 , 5 .

Avanafil has strong selectivity for PDE5 compared to other PDE5 inhibitors, so it has less impact on other PDE isoenzymes, potentially leading to fewer side effects and improved tolerability. 11 .

Avanafil, like traditional PDE5 inhibitors, is contraindicated for simultaneous use with nitrates. 4 .

Reasons for Side Effects

PDE5 inhibitors work by inhibiting PDE isoenzymes found in various tissues throughout the body. While avanafil exhibits high selectivity for PDE5, it does not completely inhibit other PDE isoenzymes, which can lead to side effects. 11 .

Common Side Effects

Headache

Avanafil may cause headaches. This is because avanafil may inhibit PDE1, leading to vasodilation and potentially triggering headaches. 11 .

Facial flushing

Avanafil may cause facial flushing. This is because avanafil may inhibit PDE5, leading to vasodilation and potentially causing facial flushing. 11 .

Nasal congestion

Avanafil may cause nasal congestion. This is because avanafil may inhibit PDE5, leading to vasodilation of blood vessels in the nasal mucosa and potentially causing nasal congestion. 11 .

Indigestion

Avanafil may cause indigestion. This is because taking avanafil may inhibit the function of the digestive system. 4 .

Side Effect Management

Headache

If you experience a headache, you can try coping methods such as staying hydrated or resting. Consult a doctor if the symptoms do not improve.

Facial Flushing

If you experience facial flushing, you can try coping methods such as moving to a cool environment or using a cold towel to cool your face. Consult a doctor if the symptoms do not improve.

Nasal Congestion

If you experience nasal congestion, you can try coping methods such as using a nasal spray or taking medication to relieve nasal congestion. Consult a doctor if the symptoms do not improve.

Indigestion

If you experience indigestion, you can try coping methods such as dietary changes or taking digestive medication. Consult a doctor if the symptoms do not improve.

Comparison Between Studies

Similarities

Many studies have reported that avanafil has a faster onset and shorter duration of action compared to other PDE5 inhibitors. 12 , 9 , 5 .

Differences

Studies on the side effects of avanafil have shown variations in the types and frequencies of side effects reported across different studies. 4 , 1 .

Considerations for Applying to Real Life

Avanafil is an effective medication for treating erectile dysfunction, but it is important to be aware of the risk of side effects. When considering taking avanafil, it is crucial to consult a doctor and choose the appropriate treatment method that suits your individual situation.

Limitations of Current Research

Research on the long-term safety and efficacy of avanafil is limited.

Future Research Directions

Research on the long-term safety and efficacy of avanafil is needed.

Conclusion

Avanafil is a new PDE5 inhibitor that is effective for treating erectile dysfunction. It offers the advantage of a faster onset and shorter duration of action compared to other PDE5 inhibitors. However, avanafil also carries the risk of side effects. When considering taking avanafil, it is crucial to consult a doctor and choose the appropriate treatment method that suits your individual situation.

Literature analysis of 12 papers
Positive Content
11
Neutral Content
0
Negative Content
1
Article Type
0
1
0
9
12
2.

Recreational Use of Oral PDE5 Inhibitors: The Other Side of Midnight.

Author: MostafaTaymour, AlghobaryMoheiddin F

Erectile dysfunction treatment
Adverse effects
Recreational use

This study sheds light on the recreational use of oral phosphodiesterase type 5 inhibitors (PDE5Is) for enhancing sexual performance. It highlights the potential adverse effects of such abuse and emphasizes the need for media and health authorities to be aware of these risks and strengthen regulatory activity to protect consumers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Update on the Safety of Phosphodiesterase Type 5 Inhibitors for the Treatment of Erectile Dysfunction.

Author: YafiFaysal A, SharlipIra D, BecherEdgardo F

ED treatment
Melanoma association
Prostate cancer recurrence

This review discusses the potential association between phosphodiesterase type 5 inhibitors (PDE5Is), used for treating erectile dysfunction, and melanoma or recurrence of prostate cancer. While data suggests a potential link, further research is needed to confirm this association.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Avanafil for the treatment of erectile dysfunction.

Author: ZurawinJonathan L, StewartCarrie A, AnaissieJames E, YafiFaysal A, HellstromWayne J G

ED treatment

Erectile dysfunction (ED) is common and increasing with an aging population. While first-generation phosphodiesterase-5 (PDE5) inhibitors revolutionized ED treatment, avanafil, a second-generation PDE5 inhibitor, offers a safe and effective alternative.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Avanafil - a further step to tailoring patient needs and expectations.

Author: BoeriLuca, CapogrossoPaolo, VentimigliaEugenio, SerinoAlessandro, La CroceGiovanni, RussoAndrea, DamianoRocco, MontorsiFrancesco, SaloniaAndrea

Improved ED treatment

Avanafil, a second-generation phosphodiesterase type 5 inhibitor, is a new treatment option for erectile dysfunction, as many patients do not respond to or are dissatisfied with the currently available PDE5Is.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

The safety and efficacy of Avanafil, a new 2(nd) generation PDE5i: comprehensive review and meta-analysis.

Author: CoronaGiovanni, RastrelliGiulia, BurriAndrea, JanniniEmmanuele A, MaggiMario

Improved sexual intercourse
Reduced side effects

Avanafil demonstrated superior efficacy compared to placebo in achieving successful sexual intercourse in patients with erectile dysfunction. It appears to have comparable efficacy to first-generation PDE5 inhibitors with a lower incidence of side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil.

Author: EvansJeffery D, HillStephen R

Improved erectile dysfunction

Erectile dysfunction can be caused by various factors, but PDE5Is, like avanafil, have been successful in treating many patients. Choosing the right PDE5I should be based on patient-specific factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Avanafil for erectile dysfunction in elderly and younger adults: differential pharmacology and clinical utility.

Author: KatzEric G, TanRonny Bw, RittenbergDaniel, HellstromWayne J

Erectile dysfunction treatment

This review focuses on the second generation phosphodiesterase 5 inhibitor, avanafil, and its clinical utility in the treatment of erectile dysfunction. Avanafil's faster onset and shorter duration of action make it a preferred choice for patients with multiple comorbidities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors.

Author: BruzzichesRoberto, FrancomanoDavide, GareriPietro, LenziAndrea, AversaAntonio

ED treatment

Phosphodiesterase type 5 inhibitors (PDE5-i) are used for the treatment of erectile dysfunction (ED). In addition to tadalafil and vardenafil, three other drugs, udenafil, avanafil and mirodenafil, are marketed in some countries and appear to be promising.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability.

Author: WangRun, BurnettArthur L, HellerWarren H, OmoriKenji, KoteraJun, KikkawaKohei, YeeShiyin, DayWesley W, DiDonatoKaren, PetersonCraig A

ED treatment

Avanafil, a PDE5 inhibitor for erectile dysfunction, exhibits strong selectivity toward PDE5, potentially reducing side effects associated with inhibiting other PDE isozymes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction.

Author: LiminMa, JohnsenNiels, HellstromWayne J G

ED treatment

The study discussed the need for development of novel phosphodiesterase type 5 (PDE5) inhibitors with enhanced selectivity, faster onset of action, increased potency, and improved tolerability to better address the unmet needs of patients with erectile dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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