A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infection.

Author: BuschMichael P, DeeksSteven G, HarvillKara, HatanoHiroyu, HohRebecca, HsuePriscilla Y, MakaKristinalisa, MartinJeffrey N, PalmerSarah, ScherzerRebecca, SinclairElizabeth, WuYuaner

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To determine whether intensification with raltegravir improves endothelial function in antiretroviral-treated HIV-infected individuals. DESIGN: : Randomized, double-blinded, placebo-controlled study. METHODS: Fifty-six subjects with treatment-mediated viral suppression for at least 1 y...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/22918156

データ提供:米国国立医学図書館(NLM)

Investigating the Effects of Raltegravir Intensification on Endothelial Function in HIV-Infected Individuals

This study explores the important area of [HIV/AIDS] research by investigating the potential benefits of raltegravir intensification on endothelial function in individuals with treated HIV infection. The authors, driven by the need to better understand the cardiovascular risks associated with HIV treatment, conducted a randomized, double-blinded, placebo-controlled study to assess the impact of raltegravir intensification on endothelial function. Their findings provide valuable insights into the potential cardiovascular implications of raltegravir therapy.

Raltegravir Intensification: No Significant Impact on Endothelial Function

The study found no significant differences in endothelial function between the raltegravir intensification group and the placebo group. This finding suggests that adding raltegravir to suppressive antiretroviral therapy does not appear to have a major negative impact on cardiovascular risk, at least as measured by endothelial function. While this is a promising finding, it's crucial to note that the study was limited in its duration and scope.

Managing Cardiovascular Risk in HIV-Infected Individuals

This research highlights the importance of carefully considering the potential cardiovascular risks associated with HIV treatment. While the study found no significant negative impact of raltegravir intensification on endothelial function, it's essential to remain vigilant and conduct further research to gain a more comprehensive understanding of the long-term cardiovascular implications of antiretroviral therapy. This knowledge could empower clinicians to make informed decisions about treatment options, minimizing cardiovascular risk and optimizing patient outcomes.

Dr.Camel's Conclusion

This research, like a camel navigating a challenging desert landscape, investigates the effects of raltegravir intensification on endothelial function in HIV-infected individuals. It reveals that raltegravir intensification does not appear to have a significant negative impact on cardiovascular risk, at least as measured by endothelial function. This study, like a refreshing oasis in the desert, provides valuable insights into the potential cardiovascular implications of HIV treatment, highlighting the importance of careful monitoring and further research in this area.

Date :
  1. Date Completed 2013-01-04
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22918156

DOI: Digital Object Identifier

NIHMS407013

Related Literature

SNS
PICO Info
in preparation
Languages

English

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