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Psychological and physiological effects of bupropion compared to methylphenidate after prolonged administration in healthy volunteers (NCT00285155).

Author: ChevassusHugues, CostaFrançoise, FarretAnne, GagnolJean-Pierre, GaltierFlorence, PetitPierre, PonçonClaire-Anne, RouxClarisse

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bupropion, an antidepressant and smoking cessation therapy, shares a number of pharmacodynamic properties with methylphenidate, an amphetamine-like stimulant, after sustained administration in humans. Both drugs reduced asthenia-fatigue, increased resting diastolic blood pressure, and decreased body weight.
Paper Details　
Original Abstract of the Article :
PURPOSE: Bupropion is largely used as an antidepressant and smoking cessation therapy. The aim of this work was to compare pharmacodynamic properties of bupropion and the amphetamine-like methylphenidate after sustained administration in humans. METHODS: Twelve male volunteers completed this random...See full text at original site
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引用元：
https://doi.org/10.1007/s00228-012-1418-z

データ提供：米国国立医学図書館（NLM）

Bupropion: A Closer Look at its Pharmacodynamic Profile

Bupropion is a widely used medication for treating depression and promoting smoking cessation. This study investigates the pharmacodynamic properties of bupropion in comparison to methylphenidate, a stimulant drug, after prolonged administration in healthy volunteers. The researchers aimed to compare the effects of these two drugs on subjective feelings, cognitive performance, and physiological parameters.

Bupropion's Effects: A Comparative Study

The study reveals a number of similarities between bupropion and methylphenidate in their pharmacodynamic profiles. Both drugs were found to decrease asthenia-fatigue and increase resting diastolic blood pressure, body temperature, and decrease body weight. However, bupropion, unlike methylphenidate, did not significantly impact cognitive function, appetite, or energy consumption. These findings suggest that bupropion may share some of the properties of stimulant drugs but with a distinct effect profile.

Understanding Bupropion's Impact: A Complex Landscape

This study underscores the complexity of understanding the pharmacodynamic properties of medications. While bupropion shares some similarities with stimulant drugs, its distinct effect profile suggests that it may act through different mechanisms. Just as a desert landscape can be both beautiful and unforgiving, understanding the effects of medications requires careful observation and interpretation. Further research is needed to fully elucidate the specific mechanisms by which bupropion exerts its effects.

Dr. Camel's Conclusion

This study offers valuable insights into the pharmacodynamic properties of bupropion. While bupropion shares some similarities with stimulant drugs, it also exhibits distinct characteristics, highlighting the complex nature of drug action. Just as a camel navigates a desert landscape, understanding the effects of medications requires a careful and nuanced approach. Further research is needed to unravel the complex mechanisms by which bupropion exerts its effects, ultimately leading to safer and more effective treatments for patients.

Date :
  1. Date Completed 2013-09-27
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23052417

DOI: Digital Object Identifier

10.1007/s00228-012-1418-z

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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