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Possible mechanism for the gastro-intestinal adverse effects upon topical application of Prostaglandin F₂α analogs.

Author: CaiSuping, LiXiaohong, LiuXuyang, YanNaihong, ZhouXiaomin

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the potential mechanism underlying gastrointestinal distress after topical application of prostaglandin F(2)α analogs (PGAs) for glaucoma treatment. The findings suggest that variations in FP receptor expression levels may contribute to the variable gastrointestinal responses observed in different patients.
Paper Details　
Original Abstract of the Article :
Prostaglandin F(2)α analogs (PGAs), including latanoprost, travoprost and bimatoprost, the first choice for the pharmaceutical treatment of glaucoma, are gaining more attention on their systemic side effects in recent years. The gastro-intestinal effects are among the most reported adverse effects u...See full text at original site
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引用元：
https://doi.org/10.1016/j.mehy.2012.09.024

データ提供：米国国立医学図書館（NLM）

Prostaglandin F₂α Analogs: A Potential Source of Gastrointestinal Side Effects

Prostaglandin F(2)α analogs (PGAs), widely used to treat glaucoma, are gaining attention for their systemic side effects, particularly gastrointestinal effects. This study investigates the potential mechanisms underlying these side effects. The authors analyze a case report of a patient who developed gastrointestinal distress after topical application of PGAs, suggesting a possible link to the stimulation of smooth muscles in the gastrointestinal tract via prostanoid receptors.

PGA-induced Gastrointestinal Distress: A Complex Web of Receptor Interactions

The study proposes a mechanism for PGA-induced gastrointestinal distress, highlighting the role of prostanoid receptors in regulating smooth muscle function. The researchers suggest that the relative expression levels of FP and EP receptors might influence the severity of gastrointestinal side effects experienced by patients. This underscores the importance of understanding receptor selectivity in predicting and managing potential side effects of medications.

Navigating the Desert of Side Effects: A Personalized Approach

This study emphasizes the need for a personalized approach to managing medication side effects. It highlights the importance of considering individual variations in receptor expression and sensitivity when prescribing PGAs. The researchers suggest that careful monitoring and individualized treatment plans could help minimize the risk of gastrointestinal distress in patients using these medications.

Dr.Camel's Conclusion

This study, like a caravan encountering a sandstorm in the desert of drug side effects, explores the complex interplay between medications and receptor interactions. The findings highlight the importance of individualizing treatment plans to minimize potential side effects, ensuring the safe and effective use of medications to improve patient well-being.

Date :
  1. Date Completed 2013-06-05
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23098372

DOI: Digital Object Identifier

10.1016/j.mehy.2012.09.024

Related Literature

Article Analysis
・Side Effects of bimatoprost topical
SNS
PICO Info
in preparation
Languages

English

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