Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans.

Author: AndersonErica R, BellGuinevere H, BernsteinHilary, MalcolmRobert J, PatrickKennerly S, ReevesOwen T, StraughnArthur B

Paper Details 
Original Abstract of the Article :
Enantioselective hydrolysis of oral racemic methylphenidate (dl-MPH) by carboxylesterase 1 (CES1) limits the absolute bioavailability of the pharmacologically active d-MPH isomer to approximately 30% and that of the inactive l-MPH to only 1-2%. Coadministration of dl-MPH with ethanol results in elev...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533423/

データ提供:米国国立医学図書館(NLM)

Ethanol's Impact on Methylphenidate: A Complex Interaction in the Desert of Pharmacology

This study delves into the intricate world of drug interactions, specifically examining the effects of ethanol on methylphenidate, a stimulant medication commonly used to treat ADHD. Imagine this as a desert traveler, encountering a hidden oasis, but not knowing if the water will invigorate or intoxicate them.

The researchers investigated the impact of ethanol on both racemic methylphenidate (dl-MPH) and dexmethylphenidate (d-MPH), exploring how these interactions affect drug absorption and subjective effects. This is like carefully observing the traveler's reactions to the oasis, monitoring their behavior to understand the influence of the water.

Ethanol's Influence: A Potent Interaction in the Desert

The study revealed that ethanol significantly enhanced the absorption and subjective effects of dl-MPH, suggesting a potent interaction between these two substances. It's like a traveler encountering a powerful spring, both invigorating and intoxicating, altering their journey in unexpected ways.

Navigating the Desert of Pharmacology: A Need for Caution

This study highlights the importance of understanding drug interactions, especially when combining stimulants with alcohol. It's like navigating a desert landscape with a guide, carefully considering the potential risks and consequences of each step.

Dr. Camel's Conclusion

This study, like a desert traveler's journal, provides valuable insights into the complex interaction between ethanol and methylphenidate. It serves as a reminder that even seemingly familiar desert landscapes can harbor hidden dangers, underscoring the importance of caution and informed decision-making when navigating the realm of pharmacology.

Date :
  1. Date Completed 2013-06-25
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

23104969

DOI: Digital Object Identifier

PMC3533423

Related Literature

SNS
PICO Info
in preparation
Languages

English

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