Paper Details
- Home
- Paper Details
Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans.
Author: AndersonErica R, BellGuinevere H, BernsteinHilary, MalcolmRobert J, PatrickKennerly S, ReevesOwen T, StraughnArthur B
Original Abstract of the Article :
Enantioselective hydrolysis of oral racemic methylphenidate (dl-MPH) by carboxylesterase 1 (CES1) limits the absolute bioavailability of the pharmacologically active d-MPH isomer to approximately 30% and that of the inactive l-MPH to only 1-2%. Coadministration of dl-MPH with ethanol results in elev...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533423/
データ提供:米国国立医学図書館(NLM)
Ethanol's Impact on Methylphenidate: A Complex Interaction in the Desert of Pharmacology
This study delves into the intricate world of drug interactions, specifically examining the effects of ethanol on methylphenidate, a stimulant medication commonly used to treat ADHD. Imagine this as a desert traveler, encountering a hidden oasis, but not knowing if the water will invigorate or intoxicate them.
The researchers investigated the impact of ethanol on both racemic methylphenidate (dl-MPH) and dexmethylphenidate (d-MPH), exploring how these interactions affect drug absorption and subjective effects. This is like carefully observing the traveler's reactions to the oasis, monitoring their behavior to understand the influence of the water.
Ethanol's Influence: A Potent Interaction in the Desert
The study revealed that ethanol significantly enhanced the absorption and subjective effects of dl-MPH, suggesting a potent interaction between these two substances. It's like a traveler encountering a powerful spring, both invigorating and intoxicating, altering their journey in unexpected ways.
Navigating the Desert of Pharmacology: A Need for Caution
This study highlights the importance of understanding drug interactions, especially when combining stimulants with alcohol. It's like navigating a desert landscape with a guide, carefully considering the potential risks and consequences of each step.
Dr. Camel's Conclusion
This study, like a desert traveler's journal, provides valuable insights into the complex interaction between ethanol and methylphenidate. It serves as a reminder that even seemingly familiar desert landscapes can harbor hidden dangers, underscoring the importance of caution and informed decision-making when navigating the realm of pharmacology.
Date :
- Date Completed 2013-06-25
- Date Revised 2022-03-16
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.