Effects of dexmethylphenidate: A Synthesis of Findings from 22 Studies

  1. Home
  2. Effects of dexmethylphenidate
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of dexmethylphenidate: A Synthesis of Findings from 22 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of dexmethylphenidate: A Synthesis of Findings from 22 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Dexmethylphenidate is a type of methylphenidate used to treat attention deficit hyperactivity disorder (ADHD). 9 , 13 , 8 , 21 , 22 , 19 , 15 , 2 , 18 , 10 , , 12 , , 11 , 20 , 5 , 7 , 16 , 4 , 3 , 6 , 1 , 17 , 14 , Research suggests that dexmethylphenidate is effective in treating ADHD. 8 , 18 , 7 Dexmethylphenidate has been shown to improve attention, behavior, and performance. 20 , 7 It can also increase the effects of alcohol when taken together. 13 , 21 , 16 However, dexmethylphenidate can cause side effects such as decreased appetite, insomnia, and weight loss. 5 , 7 It can also affect the heart, and caution should be exercised in individuals with existing heart conditions or those at risk of heart disease. 15 Dexmethylphenidate can also affect sleep. 17 , 1

Benefits and Risks

Benefit Summary

Dexmethylphenidate has been shown to be effective in treating ADHD. 8 , 18 , 7 Dexmethylphenidate has been shown to improve attention, behavior, and performance. 20 , 7

Risk Summary

Dexmethylphenidate can cause side effects such as decreased appetite, insomnia, and weight loss. 5 , 7 It can also affect the heart, and caution should be exercised in individuals with existing heart conditions or those at risk of heart disease. 15 Dexmethylphenidate can also affect sleep. 17 , 1

Study Comparisons

Similarities

These studies suggest that dexmethylphenidate is effective in treating ADHD. 8 , 18 , 7 They also suggest that dexmethylphenidate can cause side effects such as decreased appetite, insomnia, and weight loss. 5 , 7

Differences

These studies have used different methods and participants to investigate the effects and side effects of dexmethylphenidate. 19 , 15 , 14 For example, some studies have varied the dosage of dexmethylphenidate to compare the effects. 20 Other studies have compared the effects of dexmethylphenidate with other ADHD medications. 14

Consistency and Contradictions in the Findings

The findings of these studies are generally consistent in suggesting that dexmethylphenidate is effective in treating ADHD. 8 , 18 , 7 However, the findings regarding side effects of dexmethylphenidate can vary between studies. 5 , 7

Implications for Real-World Applications

Dexmethylphenidate has been shown to be effective in treating ADHD, but it’s important to be aware of the potential side effects. 8 , 18 , 7 If you are considering taking dexmethylphenidate, it is important to talk to your doctor to understand the benefits and risks and to determine the appropriate dosage for you. 15 , 14 Also, be aware that dexmethylphenidate can potentiate the effects of alcohol. 13 , 21 , 16 If you are taking dexmethylphenidate, avoid alcohol consumption. 14

Limitations of Current Research

These studies do not adequately investigate the long-term effects or side effects of dexmethylphenidate. 15 They also do not fully account for individual differences in response to dexmethylphenidate, or the influence of other factors. 19 , 14

Future Research Directions

Research is needed to investigate the long-term effects and side effects of dexmethylphenidate. 15 Research is also needed to investigate individual differences in response to dexmethylphenidate and the influence of other factors. 19 , 14

Conclusion

These studies suggest that dexmethylphenidate is effective in treating ADHD. 8 , 18 , 7 However, it’s important to remember that dexmethylphenidate carries a risk of side effects. 5 , 7 If you are considering taking dexmethylphenidate, it is important to talk to your doctor to understand the benefits and risks and to determine the appropriate dosage for you. 15 , 14 Dexmethylphenidate can be an effective medication for treating ADHD, but proper use is critical. 14 These studies provide important information to help us better understand the safety and effectiveness of dexmethylphenidate. 14

Literature analysis of 22 papers
Positive Content
16
Neutral Content
2
Negative Content
4
Article Type
8
1
1
5
21
2.

Evaluating serdexmethylphenidate and dexmethylphenidate capsules as a once-daily treatment option for ADHD.

Author: BarnhardtElizabeth A, NarayananAnita R, CouryDaniel L

ADHD treatment

This article discusses the use of serdexmethylphenidate (SDX), a prodrug of dexmethylphenidate, in treating attention deficit/hyperactivity disorder (ADHD).

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Analysis of Growth Velocity in Children with Attention-Deficit/Hyperactivity Disorder Treated for up to 12 Months with Serdexmethylphenidate/Dexmethylphenidate.

Author: ChildressAnn C, CutlerAndrew J, PatelMaitrey, OhCharles

Minimal growth impact
Well-tolerated
Lower height increase
Modest weight reduction

Serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) is a medication used to treat attention-deficit/hyperactivity disorder (ADHD). This post-hoc analysis of a 12-month safety study found that long-term treatment with SDX/d-MPH was associated with modest reductions in expected weight and lower-than-expected increases in height.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Safety and Tolerability of Serdexmethylphenidate/Dexmethylphenidate Capsules in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Month, Open-Label Safety Study.

Author: ChildressAnn C, MarraffinoAndrea, CutlerAndrew J, OhCharles, BramsMatthew N

ADHD treatment
Good tolerability
Sustained efficacy

Serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) is a medication used to treat attention-deficit/hyperactivity disorder (ADHD) in children aged 6 years and older. This study assessed the long-term safety and tolerability of SDX/d-MPH in children with ADHD over a year. The results show that SDX/d-MPH was safe and well-tolerated, comparable to other methylphenidate medications, and showed sustained efficacy over the study period.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Short-Term Vision-Related Ocular Side Effects of Treatment with Dexmethylphenidate for Attention-Deficit/Hyperactivity Disorder.

Author: FainbergGilad, LeitnerYael, ZurDinah, KleinAinat, Mezad-KourshDaphna

No significant changes in visual functions
Blurred vision
Pupil size change

This study investigated the short-term effect of dexmethylphenidate (D-MPH) on visual function in children with attention-deficit/hyperactivity disorder (ADHD). The findings demonstrate a dose-dependent effect of D-MPH on pupil diameter and a correlation between complaints of blurred vision and pupil size change. However, no clinically significant differences in visual functions were found 1.5 hours after D-MPH administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

A Randomized, Controlled Laboratory Classroom Study of Serdexmethylphenidate and d-Methylphenidate Capsules in Children with Attention-Deficit/Hyperactivity Disorder.

Author: KollinsScott H, BraeckmanRene, GuentherSven, BarrettAndrew C, MickleTravis C, OhCharles, MarraffinoAndrea, CutlerAndrew J, BramsMatthew N

ADHD treatment
Decreased appetite
Insomnia

Once-daily serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) capsules were found to significantly improve ADHD symptoms in children aged 6-12 compared to placebo, with a rapid onset and extended duration of treatment effect. The treatment was safe, with adverse events comparable to other stimulant treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Severe muscle pain and stiffness due to dexmethylphenidate.

Author: KonJacob J, KonAlexander A

ADHD treatment
Muscle pain
Muscle stiffness

Dexmethylphenidate, a medication used to treat attention deficit hyperactivity disorder (ADHD), can cause severe muscle pain and stiffness. This should be considered as a possible cause if a patient with ADHD develops these symptoms.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

10.

Effects of Dexmethylphenidate on Targeted and Non-Targeted Behaviours during Functional Analyses: A Brief Report.

Author: TorelliJessica N, LambertJoseph M, FrancisRachel N, PicouCatherine G, MastelMarissa A, O'FlahertyCeCelia A, VandelaarEllen M

Reduced disruptive behavior
Collateral effects on crying

This study investigated the effects of dexmethylphenidate (DMPH), a stimulant medication used to treat attention deficit hyperactivity disorder (ADHD), on disruptive behavior in a child with multiple disabilities. Functional analyses conducted under DMPH and placebo conditions revealed that DMPH suppressed attention-maintained disruptive behavior, but may have had collateral effects on non-targeted behaviors like crying. These findings support the idea that stimulant medication can change the function of disruptive behavior and highlight the importance of considering its impact on non-targeted behaviors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Drug Regimen Individualization for Attention-Deficit/Hyperactivity Disorder: Guidance for Methylphenidate and Dexmethylphenidate Formulations.

Author: PatrickKennerly Sexton, RadkeJennifer L, RaymondJohn R, KollerLauren, NguyenLinda V, RodriguezWendy, StraughnArthur B

ADHD treatment
Improved bioavailability
Once-daily dosing
Abuse liability
Drug interactions
Side effects

Different methylphenidate (MPH) formulations are available for treating attention-deficit/hyperactivity disorder (ADHD), each with distinct exposure time courses, allowing for personalized treatment selection based on patient needs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers.

Author: ZhuHao-Jie, PatrickKennerly S, StraughnArthur B, ReevesOwen T, BernsteinHilary, ShiJian, JohnsonHeather J, KnightJoshua M, SmithAaron T, MalcolmRobert J, MarkowitzJohn S

Increased psychostimulant effects

This study investigated the interactions between ethanol and methylphenidate (MPH) formulations. The study found that ethanol significantly increases the maximum plasma concentration (Cmax) of d-MPH and overall drug exposure, potentially due to acceleration of MPH formulation gastric dissolution by ethanol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Comparative efficacy and tolerability of pharmacological interventions for attention-deficit/hyperactivity disorder in children, adolescents and adults: protocol for a systematic review and network meta-analysis.

Author: CorteseSamuele, AdamoNicoletta, Mohr-JensenChristina, HayesAdrian J, BhattiSahar, CarucciSara, Del GiovaneCinzia, AtkinsonLauren Z, BanaschewskiTobias, SimonoffEmily, ZuddasAlessandro, BarbuiCorrado, PurgatoMarianna, SteinhausenHans-Christoph, ShokranehFarhad, XiaJun, CiprianiAndrea, CoghillDavid,

ADHD treatment
Pharmacological treatment comparison

This planned network meta-analysis will rank pharmacological treatments for ADHD according to their efficacy and tolerability profiles. The analysis will integrate direct and indirect comparisons from randomized controlled trials (RCTs) to provide a comprehensive overview of available treatment options.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Acute and Long-Term Cardiovascular Effects of Stimulant, Guanfacine, and Combination Therapy for Attention-Deficit/Hyperactivity Disorder.

Author: SayerGregory R, McGoughJames J, LevittJennifer, CowenJennifer, SturmAlexandra, CasteloEdward, McCrackenJames T

Safe
Well tolerated

Guanfacine immediate-release (GUAN-IR), dexmethylphenidate extended-release (DMPH), and their combination (COMB) were well tolerated and safe in youth with attention-deficit/hyperactivity disorder. GUAN-IR reduced heart rate, while DMPH increased heart rate. COMB had intermediate effects. Long-term treatment with GUAN-IR and DMPH returned cardiovascular parameters to baseline.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Comparative Ethanol-Induced Potentiation of Stimulatory Responses to Dexmethylphenidate Versus Methylphenidate.

Author: PatrickKennerly S, StraughnArthur B, ReevesOwen T, BernsteinHilary, MalcolmRobert

ADHD treatment
Drug abuse liability

Ethanol was found to increase the effects of both dexmethylphenidate (d-MPH) and dl-methylphenidate (dl-MPH), medications used to treat attention-deficit/hyperactivity disorder (ADHD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Effect of extended-release dexmethylphenidate and mixed amphetamine salts on sleep: a double-blind, randomized, crossover study in youth with attention-deficit hyperactivity disorder.

Author: SantistebanJ A, SteinM A, BergmameL, GruberR

Later sleep start times
Reduced sleep duration

Higher stimulant doses were associated with reduced sleep duration and later sleep start times, regardless of medication class.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Methylphenidate and dexmethylphenidate formulations for children with attention-deficit/hyperactivity disorder.

Author: SugrueDavid, BognerRobin, EhretMegan J

ADHD symptom control
Less frequent dosing

Various formulations of immediate-release (IR) and intermediate- and extended-release methylphenidate and dexmethylphenidate can be useful options in the management of attention-deficit/hyperactivity disorder (ADHD). All are equally efficacious in controlling ADHD symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder.

Author: SteinMark A, WaldmanIrwin, NewcornJeffrey, BishopJeffrey, KittlesRick, CookEdwin H

Control ADHD
Higher stimulant doses

Children with attention-deficit/hyperactivity disorder (ADHD) and the 9/9 genotype may require higher stimulant doses to achieve adequate symptom control.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Extended-release dexmethylphenidate 30 mg/d versus 20 mg/d: duration of attention, behavior, and performance benefits in children with attention-deficit/hyperactivity disorder.

Author: SilvaRaul R, BramsMatthew, McCagueKevin, PestreichLinda, MunizRafael

Improved attention
Improved behavior
Improved performance

Dexmethylphenidate extended-release (D-MPH-ER) 30 mg was more effective than D-MPH-ER 20 mg in improving attention, behavior, and performance in children with attention-deficit/hyperactivity disorder (ADHD) at later time points in the day. Both doses were more effective than placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans.

Author: PatrickKennerly S, StraughnArthur B, ReevesOwen T, BernsteinHilary, BellGuinevere H, AndersonErica R, MalcolmRobert J

Increased abuse liability

This study investigated the impact of ethanol on the absorption and effects of methylphenidate (MPH) in healthy volunteers. Ethanol increased d-MPH plasma concentrations and potentiated its subjective effects when co-administered with racemic MPH, but not with pure d-MPH, suggesting that l-MPH competitively inhibits the presystemic metabolism of d-MPH.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Treatment discontinuation with methylphenidate in adults with attention deficit hyperactivity disorder: a meta-analysis of randomized clinical trials.

Author: CastellsXavier, CunillRuth, CapellàDolors

Reduced ADHD symptoms
Higher discontinuation rate

Methylphenidate, despite reducing ADHD symptoms, did not demonstrate a significant advantage over placebo in terms of treatment discontinuation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.