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Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects.

Author: AaronsonScott T, BanovMichael D, BernsteinLawrence P, BrannonGuy E, BunkerMark, CarpenterLinda L, ConwayCharles R, DunnerDavid L, HusainMustafa, KeepersGeorge A, LehmanRobert B, LesemMichael D, LisanbySarah H, MorenoFrancisco A, O'ReardonJohn P, ReimherrFrederick W, RudolphRichard L, SchwartzThomas L, ThompsonPeter M, VineCraig J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Vagus nerve stimulation (VNS) therapy was well-tolerated and showed significant improvement in depressive symptoms in patients with treatment-resistant depression (TRD). Higher electrical dose parameters were associated with greater durability of response.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Major depressive disorder is a prevalent, disabling, and often chronic or recurrent psychiatric condition. About 35% of patients fail to respond to conventional treatment approaches and are considered to have treatment-resistant depression (TRD). OBJECTIVE: We compared the safety and ef...See full text at original site
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引用元：
https://doi.org/10.1016/j.brs.2012.09.013

データ提供：米国国立医学図書館（NLM）

Vagus Nerve Stimulation: A Camel's Journey Through the Depths of Depression

The desert of depression can be a desolate and isolating place, with many individuals struggling to find relief from its debilitating effects. This research explores the use of vagus nerve stimulation (VNS) therapy as a potential oasis for individuals with treatment-resistant depression (TRD). The study, like a caravan traversing the desert, carefully compared the safety and effectiveness of different stimulation levels of VNS therapy in a large group of patients with TRD.

VNS Therapy: A Promising Oasis in the Desert of TRD

The findings, like a refreshing spring in the desert, revealed significant improvement in depressive symptoms across all treatment groups. While no significant differences were found between the different stimulation levels during the acute phase, long-term analysis indicated that higher electrical doses were associated with greater durability of response. This suggests that VNS therapy, like a resilient camel, can provide sustained relief from depression.

Navigating the Depths of Depression: A Camel's Guide

This study offers a ray of hope for individuals with TRD, highlighting the potential of VNS therapy as a viable treatment option. However, it's important to note that individual responses to VNS can vary, and careful monitoring is crucial. Like a wise traveler, we must approach this therapy with a balanced perspective, understanding both its potential benefits and limitations.

Dr.Camel's Conclusion

This research provides a compelling argument for the use of VNS therapy in the treatment of TRD. While further investigation is needed to optimize treatment parameters, VNS holds promise as a potential oasis for those struggling with this debilitating condition. The desert of depression is vast, but with innovative therapies and unwavering support, we can find pathways to healing and hope.

Date :
  1. Date Completed 2014-02-17
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

23122916

DOI: Digital Object Identifier

10.1016/j.brs.2012.09.013

Related Literature

Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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