Adverse drug reactions and outcome of short course anti-tuberculosis drugs between single daily dose and split drug dose (BID) in pulmonary tuberculosis.

Author: CheewakulKrisana, ChuchottawornCharoen, KittisupChomnapa, SaipanBenjawan

Paper Details 
Original Abstract of the Article :
Standard six months short course regimen for treatment of pulmonary tuberculosis is very effective and is recommended as standard treatment. But this regimen composes of many drugs and causes high adverse drug reactions especially gastrointestinal irritation. Spitted administration of drugs to two t...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/23130467

データ提供:米国国立医学図書館(NLM)

Single Daily Dose vs. Split Drug Dose in Pulmonary Tuberculosis

This research delves into the vast desert of pulmonary tuberculosis treatment. It's a critical quest to find the most effective way to fight this formidable foe. The study employed a rigorous comparison of two dosing methods: single daily dose and split drug dose (BID), to determine their impact on adverse drug reactions. The researchers discovered that, while the standard six-month short course regimen is quite effective, it can have a rough side-effect profile, particularly gastrointestinal irritation. Splitting drug doses into two administrations per day could potentially reduce these unwanted effects. This finding, like a refreshing oasis in the desert, offers hope for a more comfortable treatment experience for patients.

Splitting Doses Could Be Key for Comfort

The results suggest that splitting drug doses could lead to fewer adverse drug reactions, specifically in the realm of gastrointestinal discomfort. This could mean a more pleasant journey through treatment for patients.

Easing the Journey

This study, like a guiding star in the vast desert of TB research, highlights the importance of finding ways to minimize side effects during treatment. This could mean a more tolerable experience for patients, ultimately leading to better adherence and improved outcomes.

Dr.Camel's Conclusion

This study serves as a reminder that in the vast landscape of medicine, small changes in treatment strategies can have a significant impact on patient experience. Splitting drug doses could be a simple, yet effective, way to make the treatment process more comfortable for individuals battling tuberculosis.

Date :
  1. Date Completed 2012-12-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23130467

DOI: Digital Object Identifier

23130467

SNS
PICO Info
in preparation
Languages

English

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