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CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion.

Author: AhluwaliaJ S, BenowitzN L, CoxL S, FaseruB, NollenN, OkuyemiK S, TyndaleR F, ZhuA Z X

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bupropion is a medication used to promote smoking cessation. This study measured plasma bupropion and its metabolite levels in a double-blind, placebo-controlled, randomized smoking-cessation trial. It found that higher hydroxybupropion concentrations were associated with better smoking cessation outcomes, suggesting that hydroxybupropion contributes to the pharmacologic effects of bupropion.
Paper Details　
Original Abstract of the Article :
Bupropion is indicated to promote smoking cessation. Animal studies suggest that the pharmacologic activity of bupropion can be mediated by its major metabolite, hydroxybupropion. We measured plasma bupropion and its metabolite levels in a double-blind, placebo controlled, randomized smoking-cessati...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23149928

データ提供：米国国立医学図書館（NLM）

CYP2B6 and Bupropion: Unraveling the Role of Hydroxybupropion in Smoking Cessation

Bupropion is a medication commonly used to aid in smoking cessation. This study examines the role of hydroxybupropion, a major metabolite of bupropion, in the pharmacologic activity of bupropion for smoking cessation.

Metabolic Variability: Hydroxybupropion’s Impact on Smoking Cessation Outcomes

The researchers found that higher hydroxybupropion concentrations were associated with improved smoking cessation outcomes, while bupropion levels did not have a significant effect. They also identified genetic variation in CYP2B6, the enzyme that metabolizes bupropion to hydroxybupropion, as a significant source of variability in hydroxybupropion formation. These findings suggest that hydroxybupropion plays a crucial role in the pharmacologic effects of bupropion for smoking cessation.

Tailoring Treatment: Optimizing Bupropion Dosing for Individual Needs

The study underscores the importance of considering metabolic variability in drug responses. The findings suggest that individualizing bupropion dosing based on CYP2B6 genotype and achieving a specific hydroxybupropion level could improve smoking cessation outcomes. It’s like navigating a desert with a camel – understanding the camel’s individual needs and strengths can help optimize its performance and ensure a successful journey.

Dr.Camel's Conclusion

This research highlights the importance of understanding the metabolic processes that influence drug action. By considering individual genetic variations and metabolic pathways, we can tailor treatment approaches for better outcomes. It’s like learning to navigate the desert by understanding the unique properties of each camel in the caravan.

Date :
  1. Date Completed 2013-01-16
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

23149928

DOI: Digital Object Identifier

NIHMS485083

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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