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Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone.

Author: EndoYasuo, KimSiyoung, KuroishiToshinobu, OkadaSatoru, SeiryuMasahiro, SugawaraShunji, Takano-YamamotoTeruko

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bisphosphonates are medications for osteoporosis, a condition that weakens bones. Nitrogen-containing bisphosphonates (NBPs) are currently the preferred choice, but they can cause jawbone problems. This study found that two non-nitrogen-containing bisphosphonates (etidronate and clodronate) have pain-relieving effects that are independent of their effects on bone. These findings suggest that etidronate and clodronate may be safer and more effective options for osteoporosis than other bisphosphonates.
Paper Details　
Original Abstract of the Article :
Nitrogen-containing bisphosphonates (NBPs) have greater anti-bone-resorptive effects than non-nitrogen-containing bisphosphonates (non-NBPs). Hence, NBPs are the current first-choice drug for osteoporosis. However, NBPs carry a risk of osteonecrosis of jaws. Some animal and human studies suggest tha...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2012.11.031

データ提供：米国国立医学図書館（NLM）

Non-Nitrogen-Containing Bisphosphonates: A Hidden Oasis in the Desert of Osteoporosis Treatment

Osteoporosis is a debilitating condition, often described as a brittle desert landscape where bones are weakened and prone to fracture. This study explores the potential of non-nitrogen-containing bisphosphonates (non-NBPs), such as etidronate and clodronate, as alternative treatments for osteoporosis. The authors investigated the analgesic effects of these compounds, finding that they possessed potent analgesic properties, independent of their anti-bone-resorptive effects. This discovery is like finding a hidden oasis in the desert, offering a new source of relief for those struggling with the pain associated with osteoporosis.

The study also revealed that non-NBPs were effective in reducing pain at doses lower than those needed to induce anti-bone-resorptive effects. This suggests that non-NBPs may offer a safer and more targeted approach to pain management, potentially reducing the risk of side effects associated with other bisphosphonates.

Finding Relief in the Desert of Osteoporosis: A New Oasis of Pain Management

The study's findings offer a promising new path for treating the pain associated with osteoporosis. The discovery of non-NBPs as effective analgesics provides a valuable alternative for those seeking relief from this debilitating condition.

Navigating the Desert of Osteoporosis: A New Approach to Pain Management

This study highlights the importance of exploring alternative treatment options for osteoporosis. By understanding the potential of non-NBPs as analgesics, we can create a more comprehensive and effective approach to managing this condition, offering greater relief and reducing the risk of side effects.

Dr.Camel's Conclusion

This study is a testament to the vast and often hidden resources of the desert of osteoporosis research. The discovery of non-NBPs as effective analgesics offers a new oasis of relief for those struggling with the pain of this debilitating condition, promising a more comfortable and manageable future.

Date :
  1. Date Completed 2013-09-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23201069

DOI: Digital Object Identifier

10.1016/j.ejphar.2012.11.031

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Languages

English

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