Effects of etidronate: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major Research Findings

Etidronate has been shown to be effective in the treatment of postmenopausal osteoporosis. 21 It can help prevent bone loss in the spine and proximal femur in early postmenopausal women. 21 Etidronate can also be used to treat fractures caused by osteoporosis. 15 In addition, etidronate has been shown to be effective in treating osteoporosis in patients with rheumatoid arthritis. 7 Etidronate is known to have fewer side effects compared to other bisphosphonate drugs used to treat osteoporosis. 16 However, high doses of etidronate can promote the accumulation of microdamage in bones, potentially weakening them. 18 Etidronate has also been shown to inhibit the progression of vascular calcification. 12 It has also been shown to inhibit bone formation in fish. 5 Etidronate may be more effective than alendronate or risedronate in treating osteoporosis. 6 Etidronate may help regulate bone metabolism, increase bone density, and improve bone strength. 19 Etidronate may have less impact on bones compared to other bisphosphonate drugs. 3 Etidronate may reduce the risk of fractures and improve quality of life. 14 Etidronate has analgesic effects in addition to its effect on bone metabolism. 6 Etidronate may be more effective when combined with alfacalcidol in treating osteoporosis. 14 Etidronate can be a safe and effective option for treating osteoporosis. 21

Benefits and Risks

Benefit Summary

Etidronate can help prevent bone loss in the spine and proximal femur in early postmenopausal women. 21 It can also help reduce the risk of fractures and improve quality of life. 14 Etidronate may also inhibit the progression of vascular calcification. 12 Etidronate is known to have fewer side effects compared to other bisphosphonate drugs used to treat osteoporosis. 16 Etidronate may help regulate bone metabolism, increase bone density, and improve bone strength. 19 Etidronate can also be used to treat fractures and osteoporosis in patients with rheumatoid arthritis. 15 Etidronate may be more effective when combined with alfacalcidol in treating osteoporosis. 14

Risk Summary

High doses of etidronate can promote the accumulation of microdamage in bones, potentially weakening them. 18 Etidronate may have less impact on bones compared to other bisphosphonate drugs. 3

Comparison Between Studies

Commonalities Among Studies

Multiple studies have shown that etidronate is effective in treating osteoporosis. 21 Many studies have shown that etidronate reduces bone loss and the risk of fractures. 21 Etidronate has also been shown to be effective in treating fractures caused by osteoporosis. 15

Differences Among Studies

The effects of etidronate may vary depending on the dose and method of administration. 18 The effectiveness of etidronate may also vary depending on individual factors such as body type and medical condition. 3 Etidronate may have less impact on bones compared to other bisphosphonate drugs. 3 Etidronate has also been shown to inhibit the progression of vascular calcification. 12 It has also been shown to inhibit bone formation in fish. 5 Etidronate may be more effective than alendronate or risedronate in treating osteoporosis. 6 Etidronate may help regulate bone metabolism, increase bone density, and improve bone strength. 19

Consistency and Contradictions in Results

Many studies have shown that etidronate is effective in treating osteoporosis. 21 However, high doses of etidronate can promote the accumulation of microdamage in bones, potentially weakening them. 18 Therefore, the dose and method of administration of etidronate need to be carefully considered. 18 The effectiveness of etidronate may also vary depending on individual factors such as body type and medical condition. 3

Things to Consider When Applying the Results to Daily Life

Etidronate has been shown to be effective in treating osteoporosis. 21 However, high doses of etidronate can promote the accumulation of microdamage in bones, potentially weakening them. 18 Therefore, you should always follow your doctor's instructions regarding the dose and method of administration of etidronate. 18 Etidronate may interact with other medications. 3 Therefore, you should always consult your doctor about any other medications you are taking when you are taking etidronate. 3

Limitations of Current Research

The long-term effects of etidronate have not been fully studied. 11 Further research is needed to better understand the safety of etidronate. 3 While etidronate may have less impact on bones compared to other bisphosphonate drugs, the long-term effects are still not fully understood. 3

Future Research Directions

Further research is needed on the long-term effects and safety of etidronate. 11 Studies comparing the effects of etidronate with other bisphosphonate drugs are also needed. 6 Etidronate may have less impact on bones compared to other bisphosphonate drugs, but long-term effects need further research. 3 Etidronate has also been shown to inhibit the progression of vascular calcification. 12 This effect needs to be further investigated. 12

Conclusion

Many studies have shown that etidronate is effective in treating osteoporosis. 21 However, high doses of etidronate can promote the accumulation of microdamage in bones, potentially weakening them. 18 Therefore, the dose and method of administration of etidronate need to be carefully considered. 18 Etidronate can be a safe and effective option for treating osteoporosis, but it's important to follow your doctor's instructions. 21 If you are concerned about osteoporosis, consult your doctor and receive appropriate treatment.

Literature analysis of 21 papers
Positive Content
18
Neutral Content
2
Negative Content
1
Article Type
9
0
0
0
21
2.

Neuroprotective Effects of Etidronate and 2,3,3-Trisphosphonate Against Glutamate-Induced Toxicity in PC12 Cells.

Author: LiWen, CheongYuen-Ki, WangHui, RenGuogang, YangZhuo

Neuroprotection

This study investigated the neuroprotective effects of etidronate and TrisPP, two bisphosphonate derivatives, on glutamate-injured PC12 cells. TrisPP exhibited remarkable cell protection and attenuated cell apoptosis, reactive oxygen species generation, Ca(2+) overloading and caspase-3 protein expression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of etidronate on the Enpp1⁻/⁻ mouse model of generalized arterial calcification of infancy.

Author: HuesaCarmen, StainesKatherine A, MillánJose Luis, MacRaeVicky E

Treats GACI
Bone demineralization

This study examines the effects of etidronate, a bisphosphonate drug, on vascular and skeletal calcification in a mouse model of generalized arterial calcification of infancy (GACI). The study shows that etidronate has detrimental effects on bone mineralisation and does not effectively prevent or arrest vascular calcification.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone.

Author: KimSiyoung, SeiryuMasahiro, OkadaSatoru, KuroishiToshinobu, Takano-YamamotoTeruko, SugawaraShunji, EndoYasuo

Analgesic effect
Osteoporosis treatment
Osteonecrosis of jaws

Bisphosphonates are medications for osteoporosis, a condition that weakens bones. Nitrogen-containing bisphosphonates (NBPs) are currently the preferred choice, but they can cause jawbone problems. This study found that two non-nitrogen-containing bisphosphonates (etidronate and clodronate) have pain-relieving effects that are independent of their effects on bone. These findings suggest that etidronate and clodronate may be safer and more effective options for osteoporosis than other bisphosphonates.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparison of the analgesic effects of bisphosphonates: etidronate, alendronate and risedronate by electroalgometry utilizing the fall of skin impedance.

Author: FujitaTakuo, OhueMutsumi, FujiiYoshio, MiyauchiAkimitsu, TakagiYasuyuki

Pain relief

This study compared the pain-relieving effects of three different types of bisphosphonate medications – etidronate, alendronate, and risedronate – in women with osteoporosis and/or osteoarthritis. The study found that etidronate was the most effective at reducing pain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Osteoclast inhibitory effects of vitamin K2 alone or in combination with etidronate or risedronate in patients with rheumatoid arthritis: 2-year results.

Author: MorishitaMinoru, NagashimaMasakazu, WaukeKoichi, TakahashiHiroshi, TakenouchiKenji

Inhibited osteoclast induction
Reduced bone loss

Vitamin K2, alone or in combination with bisphosphonates, may inhibit osteoclast induction by decreasing RANKL levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis.

Author: NittaKosaku, AkibaTakashi, SuzukiKoichi, UchidaKeiko, WatanabeRyo-Ichiro, MajimaKazuhiro, AokiTakanao, NiheiHiroshi

Reduced CAC score

Coronary artery calcification (CAC) is more common in people with end-stage renal disease and is associated with higher cardiovascular mortality. This study will assess the effect of etidronate on the progression of CAC scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Effects of discontinuation as well as intervention of cyclic therapy with etidronate on bone remodeling after cementless total hip arthroplasty.

Author: YamaguchiKatsuyuki, MasuharaKensaku, YamasakiSatoshi, FujiTakeshi, SeinoYoshiki

Periprosthetic bone mineral density improvement

CTE (cyclic therapy with etidronate) was studied to see its effects on bone mineral density around hip replacements.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Inhibitory effects of etidronate on the progression of vascular calcification in hemodialysis patients.

Author: HashibaHirotake, AizawaSumio, TamuraKazuhiro, ShigematsuTakashi, KogoHiroshi

Aortic calcification inhibition

This study examines the effectiveness of etidronate in inhibiting aortic calcification in hemodialysis (HD) patients. The results suggest that etidronate significantly suppressed the progression of vascular calcification without altering serum calcium and phosphorus levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Comparative effects of treatment with etidronate and alendronate on bone resorption, back pain, and activities of daily living in elderly women with vertebral fractures.

Author: IwamotoJun, TakedaTsuyoshi, IchimuraShoichi, UzawaMitsuyoshi

ADL improvement
Back pain reduction
Bone resorption reduction

This study compared the effects of etidronate and alendronate on bone resorption, back pain, and activities of daily living (ADL) in elderly women with vertebral fractures. Both treatments were effective, but the mechanism for the reduction in back pain differed between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Effects of cyclical etidronate with alfacalcidol on lumbar bone mineral density, bone resorption, and back pain in postmenopausal women with osteoporosis.

Author: IwamotoJun, TakedaTsuyoshi, IchimuraShoichi, MatsuKenjiro, UzawaMitsuyoshi

Back pain relief
Bone mineral density increase
Bone resorption reduction

Cyclical etidronate combined with alfacalcidol was more effective than cyclical etidronate alone in increasing lumbar bone mineral density and reducing bone resorption in postmenopausal women with osteoporosis. Both treatments reduced back pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Effects of treatment with etidronate and alfacalcidol for osteogenesis imperfecta type I: a case report.

Author: IwamotoJun, MatsuKenjiro, TakedaTsuyoshi, IchimuraShoichi, UzawaMitsuyoshi

Osteogenesis imperfecta treatment

A 36-year-old man with osteogenesis imperfecta type I was successfully treated with oral etidronate and alfacalcidol for 18 months, resulting in increased bone mineral density and decreased back pain.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro.

Author: StillK, PhippsR J, ScuttA

Bone Formation Stimulation
Cytotoxicity

Risedronate and alendronate are drugs used to treat osteoporosis. They can have different effects on bone cells depending on the dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Synchrotron radiation microtomography allows the analysis of three-dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effects of etidronate treatment.

Author: NuzzoS, Lafage-ProustM H, Martin-BadosaE, BoivinG, ThomasT, AlexandreC, PeyrinF

Improved bone mineralization

This study assessed the effects of sequential etidronate therapy on bone microarchitecture and mineralization in postmenopausal osteoporosis using quantitative microcomputed tomography. The study found that etidronate treatment showed a trend towards increased bone mineralization, but no significant changes in bone mass or structural parameters.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Additive effects of combined treatment with etidronate and alfacalcidol on bone mass and mechanical properties in ovariectomized rats.

Author: NishikawaT, OgawaS, KogitaK, ManabeN, KatsumataT, NakamuraK, KawaguchiH

Improved mechanical properties
Increased bone density

This study investigated the effects of combined treatment with etidronate and alfacalcidol on bone mass and mechanical properties in ovariectomized rats. The combination treatment was found to be more effective than either treatment alone in increasing bone mass and strength.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Acute effects of etidronate on glucocorticoid-induced bone degradation.

Author: StruijsA, SmalsA, de WitteS A, HackengW H, MulderH

Increased osteocalcin
Prevented bone resorption

Etidronate is acutely able to prevent bone resorption due to corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

The effects of cyclical etidronate on early postmenopausal bone loss: an open, randomized controlled study.

Author: HeathD A, BullivantB G, BoivenC, BalenaR

Bone loss prevention
Osteoporosis treatment
Hormone replacement therapy alternative

Cyclical etidronate therapy prevents bone loss in the spine and proximal femur in early postmenopausal women. It is a safe and effective alternative for women who are unable or unwilling to tolerate hormone replacement therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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