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Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review.

Author: BaldessariniRoss J, FaeddaGianni L, MarangoniCiro, OffidaniEmanuela, SerraGiulia, TondoLeonardo, VázquezGustavo H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review analyzed reports of patients diagnosed with MDD and treated with an AD. The overall risk of mood-switching was 8.18%. The risk was 2.6 times greater with AD-treatment compared to without AD-treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Compare reported rates of mood-shifts from major depression to mania/hypomania/mixed-states during antidepressant (AD)-treatment and rates of diagnostic change from major depressive disorder (MDD) to bipolar disorder (BPD). METHODS: Searching computerized literature databases, followed ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2012.10.033

データ提供：米国国立医学図書館（NLM）

Antidepressant-Associated Mood-Switching and Bipolar Disorder

The mind, a complex desert of thoughts and emotions, can be a challenging landscape to navigate, particularly when grappling with mental health conditions. This study investigates the potential link between antidepressant treatment and mood-switching, a shift from depression to mania or hypomania, and the subsequent diagnosis of bipolar disorder.

Unraveling the Complexities of Mood Disorders

The authors conducted a comprehensive literature review, combing through the vast desert of research data to analyze the incidence of mood-switching during antidepressant treatment. Their findings revealed a concerning trend: a significant percentage of patients diagnosed with major depressive disorder (MDD) experienced mood-switching while on antidepressants. This is like discovering a hidden current in a seemingly calm desert lake, a force that can unexpectedly shift the direction of one’s journey.

Navigating the Uncertain Terrain of Mood-Switching

The study also explored the association between mood-switching and the subsequent diagnosis of bipolar disorder. It found that while mood-switching occurred at a higher rate during antidepressant treatment, the rate of new bipolar disorder diagnoses was significantly lower. This is like recognizing a new path in the desert, one that may be influenced by the journey taken but not entirely determined by it. The research highlights the complex interplay between antidepressant treatment, mood-switching, and bipolar disorder, underscoring the need for careful monitoring and personalized treatment plans.

Dr.Camel's Conclusion

This study sheds light on the intricate connection between antidepressant treatment, mood-switching, and bipolar disorder. It's a reminder that the mind, like a vast desert, can be a complex and unpredictable landscape. As we navigate the challenges of mental health, careful observation, individualized treatment, and a thorough understanding of the potential risks and benefits are essential.
Date :
  1. Date Completed 2013-11-08
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

23219059

DOI: Digital Object Identifier

10.1016/j.jad.2012.10.033

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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