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Molecular modeling, docking and ADMET studies towards development of novel Disopyramide analogs for potential inhibition of human voltage gated sodium channel proteins.
Author: BhaskarMatcha, ChristinaN Blessy, DesaiNidhi, MahtoManoj Kumar, MerajKhunza, ShahbaziSajad
Original Abstract of the Article :
The sodium "channelopathies" are the first among the ion channel diseases identified and have attracted widespread clinical and scientific interests. Human voltage gated sodium channels are sites of action of several antiarrhythmic drugs, local anesthetics and related antiepileptic drugs. The presen...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530882/
データ提供:米国国立医学図書館(NLM)
Developing Novel Disopyramide Analogs for Sodium Channelopathies: A Molecular Journey
This research delves into the intricate world of molecular modeling and drug design, focusing on developing novel analogs of Disopyramide for potential inhibition of human voltage-gated sodium channel proteins. It's like building a new type of camel, specifically designed for navigating a complex desert landscape, with the goal of overcoming the challenges faced by traditional camels.
Disopyramide Analogs: Targeting Sodium Channelopathies
The study aims to optimize the activity of Disopyramide by designing and testing new analogs that target sodium channel proteins, specifically human voltage-gated sodium channel protein type 5. It's like finding a new oasis that offers a more efficient and effective way to sustain life in the desert, compared to traditional oases.
Molecular Modeling and Drug Design: A Powerful Tool
The study highlights the power of molecular modeling and drug design in developing new and improved medications. It's like having a detailed map of the desert landscape, allowing researchers to identify the most promising pathways for designing effective treatments.
Dr.Camel's Conclusion
This study is a testament to the innovative power of molecular modeling and drug design. By creating new analogs of Disopyramide, researchers can potentially develop more effective treatments for sodium channelopathies. It's like discovering a new species of camel that is better equipped to thrive in the challenging desert environment.
Date :
- Date Completed 2013-01-01
- Date Revised 2021-10-21
Further Info :
Related Literature
English
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