Cannabidiol enhances consolidation of explicit fear extinction in humans.

Author: CurranH Valerie, DasRavi K, GuptaVivek, KambojSunjeev K, MorganCelia J A, RamadasMayurun, RedmanEmily, YoganKishoj

Paper Details 
Original Abstract of the Article :
RATIONALE: Whilst Cannabidiol (CBD), a non-psychotomimetic cannabinoid, has been shown to enhance extinction learning in rats, its effects on fear memory in humans have not previously been studied. OBJECTIVES: We employed a Pavlovian fear-conditioning paradigm in order to assess the effects of CBD ...See full text at original site
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引用元:
https://doi.org/10.1007/s00213-012-2955-y

データ提供:米国国立医学図書館(NLM)

Cannabidiol: A New Oasis in Fear Extinction

This study explores the potential of cannabidiol (CBD), a non-psychoactive cannabinoid, to enhance fear extinction learning in humans. The researchers employed a Pavlovian fear-conditioning paradigm to assess the effects of CBD on extinction and consolidation. They divided 48 participants into three groups, each receiving either placebo or 32 mg of CBD before or after extinction. The results showed that CBD given post-extinction significantly enhanced the consolidation of extinction learning as measured by shock expectancy. While CBD administered at either time point trended towards a reduction in reinstatement of autonomic contextual responding, no acute effects were observed on extinction itself. This research provides the first evidence that CBD can enhance the consolidation of extinction learning in humans, suggesting its potential as an adjunct to extinction-based therapies for anxiety disorders.

The Promise of CBD: A Beacon of Hope for Anxiety

This study offers a glimmer of hope for individuals struggling with anxiety disorders. The findings suggest that CBD may have a significant role in enhancing fear extinction learning, a crucial element in overcoming anxiety. The ability of CBD to strengthen the consolidation of extinction learning could lead to more durable and long-lasting relief from anxiety symptoms.

CBD and Fear Extinction: A Journey Through the Desert of Anxiety

This study provides a fascinating glimpse into the potential of CBD to address the challenges of anxiety. Just as a camel navigating the vast desert seeks out oases for relief and sustenance, individuals with anxiety may find solace in the potential therapeutic benefits of CBD. Further research is needed to fully understand the mechanisms and efficacy of CBD in treating anxiety, but the preliminary findings are promising and offer a new avenue for exploration.

Dr.Camel's Conclusion

This study offers a promising new direction in the treatment of anxiety disorders. CBD's potential to enhance fear extinction learning represents a significant breakthrough, offering a glimmer of hope for individuals seeking relief from the debilitating effects of anxiety. As we continue to explore the vast desert of anxiety research, we may find that CBD holds a key to unlocking new and effective therapies for this widespread condition.

Date :
  1. Date Completed 2013-10-28
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23307069

DOI: Digital Object Identifier

10.1007/s00213-012-2955-y

Related Literature

SNS
PICO Info
in preparation
Languages

English

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