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Cannabidiol enhances consolidation of explicit fear extinction in humans.
Author: CurranH Valerie, DasRavi K, GuptaVivek, KambojSunjeev K, MorganCelia J A, RamadasMayurun, RedmanEmily, YoganKishoj
Original Abstract of the Article :
RATIONALE: Whilst Cannabidiol (CBD), a non-psychotomimetic cannabinoid, has been shown to enhance extinction learning in rats, its effects on fear memory in humans have not previously been studied. OBJECTIVES: We employed a Pavlovian fear-conditioning paradigm in order to assess the effects of CBD ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s00213-012-2955-y
データ提供:米国国立医学図書館(NLM)
Cannabidiol: A New Oasis in Fear Extinction
This study explores the potential of cannabidiol (CBD), a non-psychoactive cannabinoid, to enhance fear extinction learning in humans. The researchers employed a Pavlovian fear-conditioning paradigm to assess the effects of CBD on extinction and consolidation. They divided 48 participants into three groups, each receiving either placebo or 32 mg of CBD before or after extinction. The results showed that CBD given post-extinction significantly enhanced the consolidation of extinction learning as measured by shock expectancy. While CBD administered at either time point trended towards a reduction in reinstatement of autonomic contextual responding, no acute effects were observed on extinction itself. This research provides the first evidence that CBD can enhance the consolidation of extinction learning in humans, suggesting its potential as an adjunct to extinction-based therapies for anxiety disorders.
The Promise of CBD: A Beacon of Hope for Anxiety
This study offers a glimmer of hope for individuals struggling with anxiety disorders. The findings suggest that CBD may have a significant role in enhancing fear extinction learning, a crucial element in overcoming anxiety. The ability of CBD to strengthen the consolidation of extinction learning could lead to more durable and long-lasting relief from anxiety symptoms.
CBD and Fear Extinction: A Journey Through the Desert of Anxiety
This study provides a fascinating glimpse into the potential of CBD to address the challenges of anxiety. Just as a camel navigating the vast desert seeks out oases for relief and sustenance, individuals with anxiety may find solace in the potential therapeutic benefits of CBD. Further research is needed to fully understand the mechanisms and efficacy of CBD in treating anxiety, but the preliminary findings are promising and offer a new avenue for exploration.
Dr.Camel's Conclusion
This study offers a promising new direction in the treatment of anxiety disorders. CBD's potential to enhance fear extinction learning represents a significant breakthrough, offering a glimmer of hope for individuals seeking relief from the debilitating effects of anxiety. As we continue to explore the vast desert of anxiety research, we may find that CBD holds a key to unlocking new and effective therapies for this widespread condition.
Date :
- Date Completed 2013-10-28
- Date Revised 2021-10-21
Further Info :
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