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Pharmacokinetic comparison of acetaminophen elixir versus suppositories in vaccinated infants (aged 3 to 36 months): a single-dose, open-label, randomized, parallel-group design.

Author: CasavantMarcel J, EdgeJames, HalvorsenMark, KelleyMichael T, WalsonPhilip D

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

The rectal suppository and elixir preparations of acetaminophen (ACET) produced similar, rapid peak concentrations and elimination t(½). No statistically significant differences were found between either C(max) or total drug exposure.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Because of practical problems and ethical concerns, few studies of the pharmacokinetics (PK) of acetaminophen (ACET) in infants have been published. OBJECTIVE: The goal of this study was to compare the PK of an ACET rectal suppository with a commercially available ACET elixir to complet...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinthera.2012.12.016

データ提供：米国国立医学図書館（NLM）

Acetaminophen: A Reliable Oasis in the Desert of Infant Pain Relief

Infants are particularly vulnerable to pain and discomfort, making it essential to have safe and effective pain relievers. This study investigates the pharmacokinetics of acetaminophen administered rectally compared to orally in vaccinated infants. The researchers found that both rectal and oral preparations of acetaminophen produced similar, rapid absorption profiles, providing comparable pain relief. This study suggests that rectal administration of acetaminophen can be a valuable option for managing pain and discomfort in infants, particularly when oral administration is challenging.

Acetaminophen: A Versatile Oasis in the Desert of Pain Management

The study's findings provide reassurance that rectal acetaminophen can be a reliable and effective alternative for infants experiencing pain and discomfort. The comparable absorption profiles suggest that this route of administration can provide similar pain relief as oral administration. This research contributes to the growing body of knowledge supporting the safe and effective use of acetaminophen in infants.

Navigating the Desert of Infant Pain Relief

Managing pain and discomfort in infants can be a challenging journey through the desert of healthcare. This study highlights the value of rectal acetaminophen as a versatile and effective option for pain relief, especially in situations where oral administration is impractical. By staying informed about the latest research and consulting with healthcare professionals, we can navigate this desert with greater confidence and ensure the well-being of our youngest patients.

Dr. Camel's Conclusion

Acetaminophen emerges as a reliable oasis in the desert of infant pain relief, offering a safe and effective option for managing discomfort. This study's findings highlight the value of rectal administration, providing a versatile approach to pain management in infants. As we continue to explore the vast desert of pediatric pain relief, it's essential to embrace research advancements and ensure that our youngest patients receive the best possible care.

Date :
  1. Date Completed 2013-08-13
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

23351277

DOI: Digital Object Identifier

10.1016/j.clinthera.2012.12.016

Related Literature

Article Analysis
・Effects of acetaminophen rectal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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